Evaluation of the anti-Inflammatory and antinociceptive effects of the essential oil from leaves of Xylopia laevigata in experimental models

• Autor(a) principal: Antoniolli, Ângelo Roberto
• Data de Publicação: 2014
• Outros Autores: Queiroz, João Carlos C., Quintans-Júnior, Lucindo José, Brito, Renan Guedes de, Barreto, Rosana de Souza Siqueira, Costa, Emmanoel Vilaça, Silva, Thanany Brasil da, Prata, Ana Paula do Nascimento, Lucca Júnior, Waldecy de, Almeida, Jackson Roberto Guedes da Silva, Lima, Julianeli Tolentino de, Quintans, Jullyana de Souza Siqueira
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFS
• Texto Completo: https://ri.ufs.br/handle/riufs/1212
• topic: Xylopia laevigata (Annonaceae); Atividade antinociceptiva; Anti-inflamatório

Xylopia laevigata (Annonaceae) is a medicinal plant used in folk medicine to treat pain and inflammation. Thus, we investigated the possible antioxidant, antinociceptive, and anti-inflammatory effects of X. laevigata leaf essential oil (EOX) in animal models. Our EOX sample showed the presence of y-muurolene (17.78%), o-cadinene (12.23%), bicyclogermacrene (7.77%), and a-copaene (7.17%) as main compounds. EOX presented a strong antioxidant potential according to the DPPH, TBARS, and nitrite production tests. Additionally, pretreatment with EOX, in mice, also significantly produced (p < 0.05 or p < 0.001) antinociceptive effect by reduction of nociceptive behavior (in formalin and writhing tests). The EOX showed c-Fos label in the olfactory bulb, piriform cortex, and periaqueductal gray. Acute administration of EOX exhibited a significant (p < 0.01 or p < 0.001) anti-inflammatory profile in the carrageenan-induced peritonitis and by the carrageenan-induced hindpaw edema tests in mice. Our results provide evidence for the use of X. laevigata by traditional medicine practitioners in the management of pain and inflammatory disorders.