Regression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Study

Detalhes bibliográficos
Autor(a) principal: Schmidt, Maria Inês
Data de Publicação: 2021
Outros Autores: Bracco, Paula, Canhada, Scheine, Guimarães, Joanna M.N., Barreto, Sandhi Maria, Chor, Dóra, Griep, Rosane Harter, Yudkin, John S., Duncan, Bruce B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/45860
Resumo: Universidade Federal do Rio Grande do Sul. Escola de Medicina. Hospital de Clínicas. Programa de Pós-Graduação em Epidemiologia. Porto Alegre, RS, Brasil.
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spelling Schmidt, Maria InêsBracco, PaulaCanhada, ScheineGuimarães, Joanna M.N.Barreto, Sandhi MariaChor, DóraGriep, Rosane HarterYudkin, John S.Duncan, Bruce B.2021-01-28T18:04:23Z2021-01-28T18:04:23Z2021SCHMIDT, Maria Inês et al. Regression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Study. Diabetes Care, v. 44, p. 81-88, Jan. 2021.0149-5992https://www.arca.fiocruz.br/handle/icict/4586010.2337/figshare.130872711935-5548engAmerican Diabetes AssociationEstudo ELSA-BrasilRegressãoGlicemia 3,8TriagemTriagemGlicemia 3,8ELSA-Brasil StudyRegressionScreeningRegression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio Grande do Sul. Escola de Medicina. Hospital de Clínicas. Programa de Pós-Graduação em Epidemiologia. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Escola de Medicina. Hospital de Clínicas. Programa de Pós-Graduação em Epidemiologia. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Escola de Medicina. Hospital de Clínicas. Programa de Pós-Graduação em Epidemiologia. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.Universidade Federal de Minas Gerais. Escola de Medicina. Belo Horizonte, MG, Brasil / University College London. Division of Medicine. London, UK.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Educação em Ambiente e Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Educação em Ambiente e Saúde. Rio de Janeiro, RJ, Brasil.University College London. Division of Medicine. London, UK.Universidade Federal do Rio Grande do Sul. Escola de Medicina. Hospital de Clínicas. Programa de Pós-Graduação em Epidemiologia. Porto Alegre, RS, Brasil.OBJECTIVE Glycemic regression is common in real-world settings, but the contribution of regression to the mean (RTM) has been little investigated. We aimed to estimate glycemic regression before and after adjusting for RTM in a free-living cohort of adults with newly ascertained diabetes and intermediate hyperglycemia (IH). RESEARCH DESIGN AND METHODS The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a cohort study of 15,105 adults screened between 2008 and 2010 with standardized oral glucose tolerance test and HbA1c, repeated after 3.84 6 0.42 years. After excluding those receiving medical treatment for diabetes, we calculated partial or complete regression before and after adjusting baseline values for RTM. RESULTS Regarding newly ascertained diabetes, partial or complete regression was seen in 49.4% (95% CI 45.2–53.7); after adjustment for RTM, in 20.2% (95% CI 12.1–28.3). Regarding IH, regression to normal levels was seen in 39.5% (95% CI 37.9–41.3) or in 23.7% (95% CI 22.6–24.3), depending on use of the World Health Organization (WHO) or the American Diabetes Association (ADA) definition, respectively; after adjustment, corresponding frequencies were 26.1% (95% CI 22.4–28.1) and 19.4% (95% CI 18.4–20.5). Adjustment for RTM reduced the number of cases detected at screening: 526 to 94 cases of diabetes, 3,118 to 1,986 cases of WHO-defined IH, and 6,182 to 5,711 cases of ADA-defined IH. Weight loss ‡2.6% was associated with greater regression from diabetes (relative risk 1.52, 95% CI 1.26–1.84) and IH (relative risk 1.30, 95% CI 1.17–1.45). CONCLUSIONS In this quasi–real-world setting, regression from diabetes at∼4 years was common, less so for IH. Regression was frequently explained by RTM but, in part, also related to improved weight loss and homeostasis over the follow-up.CONCLUSIONS In this quasi–real-world setting, regression from diabetes at∼4 years was common, less so for IH. 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dc.title.pt_BR.fl_str_mv Regression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Study
title Regression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Study
spellingShingle Regression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Study
Schmidt, Maria Inês
Estudo ELSA-Brasil
Regressão
Glicemia 3,8
Triagem
Triagem
Glicemia 3,8
ELSA-Brasil Study
Regression
Screening
title_short Regression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Study
title_full Regression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Study
title_fullStr Regression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Study
title_full_unstemmed Regression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Study
title_sort Regression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Study
author Schmidt, Maria Inês
author_facet Schmidt, Maria Inês
Bracco, Paula
Canhada, Scheine
Guimarães, Joanna M.N.
Barreto, Sandhi Maria
Chor, Dóra
Griep, Rosane Harter
Yudkin, John S.
Duncan, Bruce B.
author_role author
author2 Bracco, Paula
Canhada, Scheine
Guimarães, Joanna M.N.
Barreto, Sandhi Maria
Chor, Dóra
Griep, Rosane Harter
Yudkin, John S.
Duncan, Bruce B.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Schmidt, Maria Inês
Bracco, Paula
Canhada, Scheine
Guimarães, Joanna M.N.
Barreto, Sandhi Maria
Chor, Dóra
Griep, Rosane Harter
Yudkin, John S.
Duncan, Bruce B.
dc.subject.other.pt_BR.fl_str_mv Estudo ELSA-Brasil
Regressão
Glicemia 3,8
Triagem
Triagem
topic Estudo ELSA-Brasil
Regressão
Glicemia 3,8
Triagem
Triagem
Glicemia 3,8
ELSA-Brasil Study
Regression
Screening
dc.subject.en.pt_BR.fl_str_mv Glicemia 3,8
ELSA-Brasil Study
Regression
Screening
description Universidade Federal do Rio Grande do Sul. Escola de Medicina. Hospital de Clínicas. Programa de Pós-Graduação em Epidemiologia. Porto Alegre, RS, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-01-28T18:04:23Z
dc.date.available.fl_str_mv 2021-01-28T18:04:23Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SCHMIDT, Maria Inês et al. Regression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Study. Diabetes Care, v. 44, p. 81-88, Jan. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/45860
dc.identifier.issn.pt_BR.fl_str_mv 0149-5992
dc.identifier.doi.none.fl_str_mv 10.2337/figshare.13087271
dc.identifier.eissn.none.fl_str_mv 1935-5548
identifier_str_mv SCHMIDT, Maria Inês et al. Regression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Study. Diabetes Care, v. 44, p. 81-88, Jan. 2021.
0149-5992
10.2337/figshare.13087271
1935-5548
url https://www.arca.fiocruz.br/handle/icict/45860
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Diabetes Association
publisher.none.fl_str_mv American Diabetes Association
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/45860/2/RosanaHGriep_PaulaBraco_etal_IOC_2020.pdf
https://www.arca.fiocruz.br/bitstream/icict/45860/3/RosanaHGriep_PaulaBraco_etal_IOC_2020.pdf.txt
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