Regression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Study
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45860 |
Resumo: | Universidade Federal do Rio Grande do Sul. Escola de Medicina. Hospital de Clínicas. Programa de Pós-Graduação em Epidemiologia. Porto Alegre, RS, Brasil. |
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Schmidt, Maria InêsBracco, PaulaCanhada, ScheineGuimarães, Joanna M.N.Barreto, Sandhi MariaChor, DóraGriep, Rosane HarterYudkin, John S.Duncan, Bruce B.2021-01-28T18:04:23Z2021-01-28T18:04:23Z2021SCHMIDT, Maria Inês et al. Regression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Study. Diabetes Care, v. 44, p. 81-88, Jan. 2021.0149-5992https://www.arca.fiocruz.br/handle/icict/4586010.2337/figshare.130872711935-5548engAmerican Diabetes AssociationEstudo ELSA-BrasilRegressãoGlicemia 3,8TriagemTriagemGlicemia 3,8ELSA-Brasil StudyRegressionScreeningRegression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio Grande do Sul. Escola de Medicina. Hospital de Clínicas. Programa de Pós-Graduação em Epidemiologia. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Escola de Medicina. Hospital de Clínicas. Programa de Pós-Graduação em Epidemiologia. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Escola de Medicina. Hospital de Clínicas. Programa de Pós-Graduação em Epidemiologia. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.Universidade Federal de Minas Gerais. Escola de Medicina. Belo Horizonte, MG, Brasil / University College London. Division of Medicine. London, UK.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Educação em Ambiente e Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Educação em Ambiente e Saúde. Rio de Janeiro, RJ, Brasil.University College London. Division of Medicine. London, UK.Universidade Federal do Rio Grande do Sul. Escola de Medicina. Hospital de Clínicas. Programa de Pós-Graduação em Epidemiologia. Porto Alegre, RS, Brasil.OBJECTIVE Glycemic regression is common in real-world settings, but the contribution of regression to the mean (RTM) has been little investigated. We aimed to estimate glycemic regression before and after adjusting for RTM in a free-living cohort of adults with newly ascertained diabetes and intermediate hyperglycemia (IH). RESEARCH DESIGN AND METHODS The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a cohort study of 15,105 adults screened between 2008 and 2010 with standardized oral glucose tolerance test and HbA1c, repeated after 3.84 6 0.42 years. After excluding those receiving medical treatment for diabetes, we calculated partial or complete regression before and after adjusting baseline values for RTM. RESULTS Regarding newly ascertained diabetes, partial or complete regression was seen in 49.4% (95% CI 45.2–53.7); after adjustment for RTM, in 20.2% (95% CI 12.1–28.3). Regarding IH, regression to normal levels was seen in 39.5% (95% CI 37.9–41.3) or in 23.7% (95% CI 22.6–24.3), depending on use of the World Health Organization (WHO) or the American Diabetes Association (ADA) definition, respectively; after adjustment, corresponding frequencies were 26.1% (95% CI 22.4–28.1) and 19.4% (95% CI 18.4–20.5). Adjustment for RTM reduced the number of cases detected at screening: 526 to 94 cases of diabetes, 3,118 to 1,986 cases of WHO-defined IH, and 6,182 to 5,711 cases of ADA-defined IH. Weight loss ‡2.6% was associated with greater regression from diabetes (relative risk 1.52, 95% CI 1.26–1.84) and IH (relative risk 1.30, 95% CI 1.17–1.45). CONCLUSIONS In this quasi–real-world setting, regression from diabetes at∼4 years was common, less so for IH. Regression was frequently explained by RTM but, in part, also related to improved weight loss and homeostasis over the follow-up.CONCLUSIONS In this quasi–real-world setting, regression from diabetes at∼4 years was common, less so for IH. Regression was frequently explained by RTM but, in part, also related to improved weight loss and homeostasis over the follow-up.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45860/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRosanaHGriep_PaulaBraco_etal_IOC_2020.pdfRosanaHGriep_PaulaBraco_etal_IOC_2020.pdfapplication/pdf2083337https://www.arca.fiocruz.br/bitstream/icict/45860/2/RosanaHGriep_PaulaBraco_etal_IOC_2020.pdf6bb1256fb683aa4b5dd24097533eab4cMD52TEXTRosanaHGriep_PaulaBraco_etal_IOC_2020.pdf.txtRosanaHGriep_PaulaBraco_etal_IOC_2020.pdf.txtExtracted texttext/plain40763https://www.arca.fiocruz.br/bitstream/icict/45860/3/RosanaHGriep_PaulaBraco_etal_IOC_2020.pdf.txtde316bb5fffec0e80e0ea51448629caaMD53icict/458602023-04-11 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dc.title.pt_BR.fl_str_mv |
Regression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Study |
title |
Regression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Study |
spellingShingle |
Regression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Study Schmidt, Maria Inês Estudo ELSA-Brasil Regressão Glicemia 3,8 Triagem Triagem Glicemia 3,8 ELSA-Brasil Study Regression Screening |
title_short |
Regression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Study |
title_full |
Regression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Study |
title_fullStr |
Regression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Study |
title_full_unstemmed |
Regression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Study |
title_sort |
Regression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Study |
author |
Schmidt, Maria Inês |
author_facet |
Schmidt, Maria Inês Bracco, Paula Canhada, Scheine Guimarães, Joanna M.N. Barreto, Sandhi Maria Chor, Dóra Griep, Rosane Harter Yudkin, John S. Duncan, Bruce B. |
author_role |
author |
author2 |
Bracco, Paula Canhada, Scheine Guimarães, Joanna M.N. Barreto, Sandhi Maria Chor, Dóra Griep, Rosane Harter Yudkin, John S. Duncan, Bruce B. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Schmidt, Maria Inês Bracco, Paula Canhada, Scheine Guimarães, Joanna M.N. Barreto, Sandhi Maria Chor, Dóra Griep, Rosane Harter Yudkin, John S. Duncan, Bruce B. |
dc.subject.other.pt_BR.fl_str_mv |
Estudo ELSA-Brasil Regressão Glicemia 3,8 Triagem Triagem |
topic |
Estudo ELSA-Brasil Regressão Glicemia 3,8 Triagem Triagem Glicemia 3,8 ELSA-Brasil Study Regression Screening |
dc.subject.en.pt_BR.fl_str_mv |
Glicemia 3,8 ELSA-Brasil Study Regression Screening |
description |
Universidade Federal do Rio Grande do Sul. Escola de Medicina. Hospital de Clínicas. Programa de Pós-Graduação em Epidemiologia. Porto Alegre, RS, Brasil. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-01-28T18:04:23Z |
dc.date.available.fl_str_mv |
2021-01-28T18:04:23Z |
dc.date.issued.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SCHMIDT, Maria Inês et al. Regression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Study. Diabetes Care, v. 44, p. 81-88, Jan. 2021. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/45860 |
dc.identifier.issn.pt_BR.fl_str_mv |
0149-5992 |
dc.identifier.doi.none.fl_str_mv |
10.2337/figshare.13087271 |
dc.identifier.eissn.none.fl_str_mv |
1935-5548 |
identifier_str_mv |
SCHMIDT, Maria Inês et al. Regression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Study. Diabetes Care, v. 44, p. 81-88, Jan. 2021. 0149-5992 10.2337/figshare.13087271 1935-5548 |
url |
https://www.arca.fiocruz.br/handle/icict/45860 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
American Diabetes Association |
publisher.none.fl_str_mv |
American Diabetes Association |
dc.source.none.fl_str_mv |
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