Aberrant IL-17 Levels in Rodent Models of Autism Spectrum Disorder: A Systematic Review

Detalhes bibliográficos
Autor(a) principal: Thawley, Alexandra Jade
Data de Publicação: 2022
Outros Autores: Veneziani, Luciana Peixoto, Ponte, Francisco Diego Rabelo da, Riederer, Ingo, Cruz, Daniella Areas Mendes da, Bambini-Junior, Victorio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/54996
Resumo: University of Central Lancashire. School of Pharmacy and Biomedical Sciences. Preston, United Kingdon.
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spelling Thawley, Alexandra JadeVeneziani, Luciana PeixotoPonte, Francisco Diego Rabelo daRiederer, IngoCruz, Daniella Areas Mendes daBambini-Junior, Victorio2022-10-05T12:33:47Z2022-10-05T12:33:47Z2022THAWLEY, Alexandra Jade et al. Aberrant IL-17 Levels in Rodent Models of Autism Spectrum Disorder: A Systematic Review. Frontiers in Immunology, v. 13, Article 874064, p. 1 - 12, June 2022.1664-3224https://www.arca.fiocruz.br/handle/icict/5499610.3389/fimmu.2022.874064engFrontiers MediaIL-17Transtorno do espectro do autismoModelos animaisRevisão sistemáticaInflamaçãoIL-17Autism spectrum disorderAnimal modelsSystematic reviewInflammationAberrant IL-17 Levels in Rodent Models of Autism Spectrum Disorder: A Systematic Reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Central Lancashire. School of Pharmacy and Biomedical Sciences. Preston, United Kingdon.University of Central Lancashire. School of Pharmacy and Biomedical Sciences. Preston, United Kingdon / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rede de Pesquisa do Rio de Janeiro em Neuroinflamação. Rio de Janeiro, RJ, Brasil.University of Central Lancashire. School of Pharmacy and Biomedical Sciences. Preston, United Kingdon / Hospital de Cl´ınicas de Porto Alegre (HCPA). Centro de Pesquisa Experimental (CPE) and Centro de Pesquisa Clínica (CPC). Laboratory of Molecular Psychiatry. POrto Alegre, RS, Brasil.University of Central Lancashire. School of Pharmacy and Biomedical Sciences. Preston, United Kingdon / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rede de Pesquisa do Rio de Janeiro em Neuroinflamação. Rio de Janeiro, RJ, Brasil.University of Central Lancashire. School of Pharmacy and Biomedical Sciences. Preston, United Kingdon / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rede de Pesquisa do Rio de Janeiro em Neuroinflamação. Rio de Janeiro, RJ, Brasil.University of Central Lancashire. School of Pharmacy and Biomedical Sciences. Preston, United Kingdon / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil / Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, United Kingdom.Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder characterised by stereotyped behaviours, specific interests, and impaired communication skills. Elevated levels of pro-inflammatory cytokines, such as interleukin- 17A (IL-17A or IL-17), have been implicated as part of immune alterations that may contribute to this outcome. In this context, rodent models have helped elucidate the role of T-cell activation and IL-17 secretion in the pathogenesis of ASD. Regarding the preclinical findings, the data available is contradictory in offspring but not in the pregnant dams, pointing to IL-17 as one of the main drivers of altered behaviour in some models ASD, whilst there are no alterations described in IL-17 levels in others. To address this gap in the literature, a systematic review of altered IL-17 levels in rodent models of ASD was conducted. In total, 28 studies that explored IL-17 levels were included and observed that this cytokine was generally increased among the different models of ASD. The data compiled in this review can help the choice of animal models to study the role of cytokines in the development of ASD, seeking a parallel with immune alterations observed in individuals with this condition. Systematic Review Registration: PROSPERO, identifier CRD42022306558info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/54996/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLucianaVeneziani_DanielaAreas_etal_IOC_2022.pdfLucianaVeneziani_DanielaAreas_etal_IOC_2022.pdfapplication/pdf814611https://www.arca.fiocruz.br/bitstream/icict/54996/2/LucianaVeneziani_DanielaAreas_etal_IOC_2022.pdf33728e4cd22bde82a4b2488d17e43707MD52icict/549962023-09-04 11:10:57.503oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-04T14:10:57Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Aberrant IL-17 Levels in Rodent Models of Autism Spectrum Disorder: A Systematic Review
title Aberrant IL-17 Levels in Rodent Models of Autism Spectrum Disorder: A Systematic Review
spellingShingle Aberrant IL-17 Levels in Rodent Models of Autism Spectrum Disorder: A Systematic Review
Thawley, Alexandra Jade
IL-17
Transtorno do espectro do autismo
Modelos animais
Revisão sistemática
Inflamação
IL-17
Autism spectrum disorder
Animal models
Systematic review
Inflammation
title_short Aberrant IL-17 Levels in Rodent Models of Autism Spectrum Disorder: A Systematic Review
title_full Aberrant IL-17 Levels in Rodent Models of Autism Spectrum Disorder: A Systematic Review
title_fullStr Aberrant IL-17 Levels in Rodent Models of Autism Spectrum Disorder: A Systematic Review
title_full_unstemmed Aberrant IL-17 Levels in Rodent Models of Autism Spectrum Disorder: A Systematic Review
title_sort Aberrant IL-17 Levels in Rodent Models of Autism Spectrum Disorder: A Systematic Review
author Thawley, Alexandra Jade
author_facet Thawley, Alexandra Jade
Veneziani, Luciana Peixoto
Ponte, Francisco Diego Rabelo da
Riederer, Ingo
Cruz, Daniella Areas Mendes da
Bambini-Junior, Victorio
author_role author
author2 Veneziani, Luciana Peixoto
Ponte, Francisco Diego Rabelo da
Riederer, Ingo
Cruz, Daniella Areas Mendes da
Bambini-Junior, Victorio
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Thawley, Alexandra Jade
Veneziani, Luciana Peixoto
Ponte, Francisco Diego Rabelo da
Riederer, Ingo
Cruz, Daniella Areas Mendes da
Bambini-Junior, Victorio
dc.subject.other.en_US.fl_str_mv IL-17
Transtorno do espectro do autismo
Modelos animais
Revisão sistemática
Inflamação
topic IL-17
Transtorno do espectro do autismo
Modelos animais
Revisão sistemática
Inflamação
IL-17
Autism spectrum disorder
Animal models
Systematic review
Inflammation
dc.subject.en.en_US.fl_str_mv IL-17
Autism spectrum disorder
Animal models
Systematic review
Inflammation
description University of Central Lancashire. School of Pharmacy and Biomedical Sciences. Preston, United Kingdon.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-10-05T12:33:47Z
dc.date.available.fl_str_mv 2022-10-05T12:33:47Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv THAWLEY, Alexandra Jade et al. Aberrant IL-17 Levels in Rodent Models of Autism Spectrum Disorder: A Systematic Review. Frontiers in Immunology, v. 13, Article 874064, p. 1 - 12, June 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/54996
dc.identifier.issn.en_US.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2022.874064
identifier_str_mv THAWLEY, Alexandra Jade et al. Aberrant IL-17 Levels in Rodent Models of Autism Spectrum Disorder: A Systematic Review. Frontiers in Immunology, v. 13, Article 874064, p. 1 - 12, June 2022.
1664-3224
10.3389/fimmu.2022.874064
url https://www.arca.fiocruz.br/handle/icict/54996
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/54996/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/54996/2/LucianaVeneziani_DanielaAreas_etal_IOC_2022.pdf
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