The influence of intestinal parasites on Plasmodium vivax‑specific antibody responses to MSP‑119 and AMA‑1 in rural populations of the Brazilian Amazon
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/14371 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. |
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Sánchez‑Arcila, Juan CamiloFrança, Marcelle Marcolino dePereira, Virgínia AraujoVasconcelos, Mariana Pinheiro AlvesTeva, AntonioSilva, Daiana de Souza Perce daRezende Neto, JoffreAprígio, Cesarino Junior LimaLima Junior, Josué da CostaRdrigues, Mauricio MartinsSoares, Irene SilvaBanic, Dalma MariaFerreira, Joseli Oliveira2016-05-19T13:14:02Z2016-05-19T13:14:02Z2015SÀNCHEZ-ARCILA, Juan Camilo; et al. The influence of intestinal parasites on Plasmodium vivax‑specific antibody responses to MSP‑119 and AMA‑1 in rural populations of the Brazilian Amazon. Malaria Journal, v.14, n.442, 11p, Nov. 2015.1475-2875https://www.arca.fiocruz.br/handle/icict/1437110.1186/s12936-015-0978-7engBioMed CentralCo-infecçãoParasitas intestinaisPopulações ruraisAmazônia BrasileiraMalariaIntestinal parasitesCo-infectionAMA-1MSP-1Plasmodium vivaxPlasmodium vivaxMaláriaThe influence of intestinal parasites on Plasmodium vivax‑specific antibody responses to MSP‑119 and AMA‑1 in rural populations of the Brazilian Amazoninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Instituto de Infectologia Emílio Ribas. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Departamento de Ciências Biológicas. Laboratório de Imunodiagnóstico.Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Simulídeos e Oncocercose. Rio de Janeiro, RJ, Brasil.Instituto de Gastroenterologia de Goiânia. Goiânia, GO, Brasil.Secretaria de Estado da Saúde - AGEVISA. Agência de Vigilância em Saúde. Rondônia, RO, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Universidade Federal de São Paulo. Escola Paulista de Medicina. Centro de Terapia Celular e Molecular (CTCMol). São Paulo, SP, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Análises Clínicas e Toxicológicas. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Simulídeos e Oncocercose. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Background: Polyparasitism is a common condition in humans but its impact on the host immune system and clinical diseases is still poorly understood. There are few studies of the prevalence and the effect of malaria-intestinal parasite co-infections in the immune response to malaria vaccine candidates. The present study determines whether the presence of malaria and intestinal parasites co-infection is associated with impaired IgG responses to Plasmodium vivax AMA-1 and MSP-119 in a rural population of the Brazilian Amazon. Methods: A cross-sectional survey was performed in a rural area of Rondonia State and 279 individuals were included in the present study. At recruitment, whole blood was collected and Plasmodium and intestinal parasites were detected by microscopy and molecular tests. Blood cell count and haemoglobin were also tested and antibody response specific to P. vivax AMA-1 and MSP-119 was measured in plasma by ELISA. The participants were grouped according to their infection status: singly infected with Plasmodium (M); co-infected with Plasmodium and intestinal parasites (CI); singly infected with intestinal parasites (IP) and negative (N) for both malaria and intestinal parasites. Results: The prevalence of intestinal parasites was significantly higher in individuals with malaria and protozoan infections were more prevalent. IgG antibodies to PvAMA-1 and/or PvMSP-119 were detected in 74 % of the popula‑ tion. The prevalence of specific IgG was similar for both proteins in all four groups and among the groups the lowest prevalence was in IP group. The cytophilic sub-classes IgG1 and IgG3 were predominant in all groups for PvAMA-1 and IgG1, IgG3 and IgG4 for PvMSP-119. In the case of non-cytophilic antibodies to PvAMA-1, IgG2 was significantly higher in IP and N group when compared to M and CI while IgG4 was higher in IP group. Conclusions: The presence of intestinal parasites, mainly protozoans, in malaria co-infected individuals does not seem to alter the antibody immune responses to P. vivax AMA-1 and MSP-119. However, IgG response to both AMA1 and MSP1 were lower in individuals with intestinal parasites.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/14371/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmarcele_frança_etal_IOC_2015.pdfmarcele_frança_etal_IOC_2015.pdfapplication/pdf1673214https://www.arca.fiocruz.br/bitstream/icict/14371/2/marcele_fran%c3%a7a_etal_IOC_2015.pdf4bd6c0b041f57820d45ba2e12ad7ca84MD52TEXTmarcele_frança_etal_IOC_2015.pdf.txtmarcele_frança_etal_IOC_2015.pdf.txtExtracted texttext/plain51776https://www.arca.fiocruz.br/bitstream/icict/14371/3/marcele_fran%c3%a7a_etal_IOC_2015.pdf.txt2cd9b19158bf41f1f36438e7128fa17aMD53icict/143712022-06-24 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| dc.title.pt_BR.fl_str_mv |
The influence of intestinal parasites on Plasmodium vivax‑specific antibody responses to MSP‑119 and AMA‑1 in rural populations of the Brazilian Amazon |
| title |
The influence of intestinal parasites on Plasmodium vivax‑specific antibody responses to MSP‑119 and AMA‑1 in rural populations of the Brazilian Amazon |
| spellingShingle |
The influence of intestinal parasites on Plasmodium vivax‑specific antibody responses to MSP‑119 and AMA‑1 in rural populations of the Brazilian Amazon Sánchez‑Arcila, Juan Camilo Co-infecção Parasitas intestinais Populações rurais Amazônia Brasileira Malaria Intestinal parasites Co-infection AMA-1 MSP-1 Plasmodium vivax Plasmodium vivax Malária |
| title_short |
The influence of intestinal parasites on Plasmodium vivax‑specific antibody responses to MSP‑119 and AMA‑1 in rural populations of the Brazilian Amazon |
| title_full |
The influence of intestinal parasites on Plasmodium vivax‑specific antibody responses to MSP‑119 and AMA‑1 in rural populations of the Brazilian Amazon |
| title_fullStr |
The influence of intestinal parasites on Plasmodium vivax‑specific antibody responses to MSP‑119 and AMA‑1 in rural populations of the Brazilian Amazon |
| title_full_unstemmed |
The influence of intestinal parasites on Plasmodium vivax‑specific antibody responses to MSP‑119 and AMA‑1 in rural populations of the Brazilian Amazon |
| title_sort |
The influence of intestinal parasites on Plasmodium vivax‑specific antibody responses to MSP‑119 and AMA‑1 in rural populations of the Brazilian Amazon |
| author |
Sánchez‑Arcila, Juan Camilo |
| author_facet |
Sánchez‑Arcila, Juan Camilo França, Marcelle Marcolino de Pereira, Virgínia Araujo Vasconcelos, Mariana Pinheiro Alves Teva, Antonio Silva, Daiana de Souza Perce da Rezende Neto, Joffre Aprígio, Cesarino Junior Lima Lima Junior, Josué da Costa Rdrigues, Mauricio Martins Soares, Irene Silva Banic, Dalma Maria Ferreira, Joseli Oliveira |
| author_role |
author |
| author2 |
França, Marcelle Marcolino de Pereira, Virgínia Araujo Vasconcelos, Mariana Pinheiro Alves Teva, Antonio Silva, Daiana de Souza Perce da Rezende Neto, Joffre Aprígio, Cesarino Junior Lima Lima Junior, Josué da Costa Rdrigues, Mauricio Martins Soares, Irene Silva Banic, Dalma Maria Ferreira, Joseli Oliveira |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Sánchez‑Arcila, Juan Camilo França, Marcelle Marcolino de Pereira, Virgínia Araujo Vasconcelos, Mariana Pinheiro Alves Teva, Antonio Silva, Daiana de Souza Perce da Rezende Neto, Joffre Aprígio, Cesarino Junior Lima Lima Junior, Josué da Costa Rdrigues, Mauricio Martins Soares, Irene Silva Banic, Dalma Maria Ferreira, Joseli Oliveira |
| dc.subject.other.pt_BR.fl_str_mv |
Co-infecção Parasitas intestinais Populações rurais Amazônia Brasileira |
| topic |
Co-infecção Parasitas intestinais Populações rurais Amazônia Brasileira Malaria Intestinal parasites Co-infection AMA-1 MSP-1 Plasmodium vivax Plasmodium vivax Malária |
| dc.subject.en.pt_BR.fl_str_mv |
Malaria Intestinal parasites Co-infection AMA-1 MSP-1 Plasmodium vivax |
| dc.subject.decs.pt_BR.fl_str_mv |
Plasmodium vivax Malária |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. |
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2015 |
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2015 |
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2016-05-19T13:14:02Z |
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2016-05-19T13:14:02Z |
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SÀNCHEZ-ARCILA, Juan Camilo; et al. The influence of intestinal parasites on Plasmodium vivax‑specific antibody responses to MSP‑119 and AMA‑1 in rural populations of the Brazilian Amazon. Malaria Journal, v.14, n.442, 11p, Nov. 2015. |
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https://www.arca.fiocruz.br/handle/icict/14371 |
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1475-2875 |
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10.1186/s12936-015-0978-7 |
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SÀNCHEZ-ARCILA, Juan Camilo; et al. The influence of intestinal parasites on Plasmodium vivax‑specific antibody responses to MSP‑119 and AMA‑1 in rural populations of the Brazilian Amazon. Malaria Journal, v.14, n.442, 11p, Nov. 2015. 1475-2875 10.1186/s12936-015-0978-7 |
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BioMed Central |
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BioMed Central |
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