A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/17818 |
Resumo: | Emory University. YerkesNational Primate Research Center. Emory Vaccine Center. Atlanta, GA, USA / Emory University. Department of Medicine. Division of Infectious Diseases. Atlanta, GA, USA. |
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Fonseca, Jairo AndresCabrera-Mora, MonicaSingh, BalwanFerreira, Joseli OliveiraLima Junior, Josué da CostaCalle, J. Mauricio CalvoLozano, Jose ManuelMoreno, Alberto2017-02-15T12:04:18Z2017-02-15T12:04:18Z2016FONSECA, Jairo Andres; et al. A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119. Scientific Reports, v.6:34527, 18p, 2016.2045-2322https://www.arca.fiocruz.br/handle/icict/1781810.1038/srep34527engNature Publishing GroupMaláriaPlasmodium vivaxVacinaPlasmodium vivax MSP119MalariaPlasmodium vivaxP. vivax Merozoite Surface Protein 1 (PvMSP119VaccineA chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleEmory University. YerkesNational Primate Research Center. Emory Vaccine Center. Atlanta, GA, USA / Emory University. Department of Medicine. Division of Infectious Diseases. Atlanta, GA, USA.Emory University. YerkesNational Primate Research Center. Emory Vaccine Center. Atlanta, GA, USA.Emory University. YerkesNational Primate Research Center. Emory Vaccine Center. Atlanta, GA, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ. Brasil.University of Massachusetts Medical School. Department of Pathology. Worcester, MA, USA.Universidad Nacional de Colombia. Department of Pharmacy. Molecular Mimetism of Infectious Agents Unit. Bogotá, Colombia.Emory University. YerkesNational Primate Research Center. Emory Vaccine Center. Atlanta, GA, USA / Emory University. Department of Medicine. Division of Infectious Diseases. Atlanta, GA, USA.The most widespread Plasmodium species, Plasmodium vivax, poses a significant public health threat. An effective vaccine is needed to reduce global malaria burden. Of the erythrocytic stage vaccine candidates, the 19 kDa fragment of the P. vivax Merozoite Surface Protein 1 (PvMSP119) is one of the most promising. Our group has previously defined several promiscuous T helper epitopes within the PvMSP1 protein, with features that allow them to bind multiple MHC class II alleles. We describe here a P. vivax recombinant modular chimera based on MSP1 (PvRMC-MSP1) that includes defined T cell epitopes genetically fused to PvMSP119. This vaccine candidate preserved structural elements of the native PvMSP119 and elicited cytophilic antibody responses, and CD4+ and CD8+ T cells capable of recognizing PvMSP119. Although CD8+ T cells that recognize blood stage antigens have been reported to control blood infection, CD8+ T cell responses induced by P. falciparum or P. vivax vaccine candidates based on MSP119 have not been reported. To our knowledge, this is the first time a protein based subunit vaccine has been able to induce CD8+ T cell against PvMSP119. The PvRMC-MSP1 protein was also recognized by naturally acquired antibodies from individuals living in malaria endemic areas with an antibody profile associated with protection from infection. These features make PvRMC-MSP1 a promising vaccine candidate.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17818/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALjoseli_ferreira_etal_IOC_2016.pdfjoseli_ferreira_etal_IOC_2016.pdfapplication/pdf1481275https://www.arca.fiocruz.br/bitstream/icict/17818/2/joseli_ferreira_etal_IOC_2016.pdf02e9a8a4d01eed2ae485bc039d32a797MD52TEXTjoseli_ferreira_etal_IOC_2016.pdf.txtjoseli_ferreira_etal_IOC_2016.pdf.txtExtracted texttext/plain102207https://www.arca.fiocruz.br/bitstream/icict/17818/3/joseli_ferreira_etal_IOC_2016.pdf.txt751eb225b2c6e3b28329a812092ee73aMD53icict/178182022-06-24 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dc.title.pt_BR.fl_str_mv |
A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119 |
title |
A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119 |
spellingShingle |
A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119 Fonseca, Jairo Andres Malária Plasmodium vivax Vacina Plasmodium vivax MSP119 Malaria Plasmodium vivax P. vivax Merozoite Surface Protein 1 (PvMSP119 Vaccine |
title_short |
A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119 |
title_full |
A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119 |
title_fullStr |
A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119 |
title_full_unstemmed |
A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119 |
title_sort |
A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119 |
author |
Fonseca, Jairo Andres |
author_facet |
Fonseca, Jairo Andres Cabrera-Mora, Monica Singh, Balwan Ferreira, Joseli Oliveira Lima Junior, Josué da Costa Calle, J. Mauricio Calvo Lozano, Jose Manuel Moreno, Alberto |
author_role |
author |
author2 |
Cabrera-Mora, Monica Singh, Balwan Ferreira, Joseli Oliveira Lima Junior, Josué da Costa Calle, J. Mauricio Calvo Lozano, Jose Manuel Moreno, Alberto |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Fonseca, Jairo Andres Cabrera-Mora, Monica Singh, Balwan Ferreira, Joseli Oliveira Lima Junior, Josué da Costa Calle, J. Mauricio Calvo Lozano, Jose Manuel Moreno, Alberto |
dc.subject.other.pt_BR.fl_str_mv |
Malária Plasmodium vivax Vacina Plasmodium vivax MSP119 |
topic |
Malária Plasmodium vivax Vacina Plasmodium vivax MSP119 Malaria Plasmodium vivax P. vivax Merozoite Surface Protein 1 (PvMSP119 Vaccine |
dc.subject.en.pt_BR.fl_str_mv |
Malaria Plasmodium vivax P. vivax Merozoite Surface Protein 1 (PvMSP119 Vaccine |
description |
Emory University. YerkesNational Primate Research Center. Emory Vaccine Center. Atlanta, GA, USA / Emory University. Department of Medicine. Division of Infectious Diseases. Atlanta, GA, USA. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2017-02-15T12:04:18Z |
dc.date.available.fl_str_mv |
2017-02-15T12:04:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FONSECA, Jairo Andres; et al. A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119. Scientific Reports, v.6:34527, 18p, 2016. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/17818 |
dc.identifier.issn.pt_BR.fl_str_mv |
2045-2322 |
dc.identifier.doi.none.fl_str_mv |
10.1038/srep34527 |
identifier_str_mv |
FONSECA, Jairo Andres; et al. A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119. Scientific Reports, v.6:34527, 18p, 2016. 2045-2322 10.1038/srep34527 |
url |
https://www.arca.fiocruz.br/handle/icict/17818 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
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