Annexin-A1-Derived Peptide Ac2-26 Suppresses Allergic Airway Inflammation and Remodelling in Mice
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.3390/cells11050759 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/51734 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. |
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Ferreira, Tatiana Paula TeixeiraGuimarães, Fernanda VerdiniSá, Yago Amigo Pinho JanniniRibeiro, Natalia Barreto da SilvaArantes, Ana Carolina Santos deCarvalho, Vinicius de FriasSousa, Lirlândia PiresPerretti, MauroMartins, Marco AurélioSilva, Patrícia Machado Rodrigues e2022-03-17T20:33:28Z2022-03-17T20:33:28Z2022FERREIRA, Tatiana Paula Teixeira et al. Annexin-A1-Derived Peptide Ac2-26 Suppresses Allergic Airway Inflammation and Remodelling in Mice. Cells, v. 11, n. 759, p. 1 - 13, Feb. 2022.2073-4409https://www.arca.fiocruz.br/handle/icict/5173410.3390/cells11050759engMDPIPulmãoInflamaçãoRemodelaçãoAsma alérgicaTerapiaPeptídeo Ac2-26LungInflammationRemodellingAllergic asthmaTherapypeptide Ac2-26Annexin-A1-Derived Peptide Ac2-26 Suppresses Allergic Airway Inflammation and Remodelling in Miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Unversidade Federal de Minas Gerais. Faculdade de Farmácia. Belo Horizonte, MG, Brasil.Department of Biochemical Pharmacology, The William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Annexin-A1 (AnxA1) and its N-terminal derived peptide Ac2-26 regulate the inflammatory response in several experimental models of disorders. This study evaluated the effect of endogenous AnxA1 and its N-terminal peptide Acetyl 2-26 (Ac2-26) on allergic asthma triggered by house dust mite (HDM) extract in mice. ANXA1/ and wildtype (WT) mice were exposed to intranasal instillation of HDM every other day for 3 weeks, with analyses performed 24 h following the last exposure. Intranasal administration of peptide Ac2-26 was performed 1 h before HDM, beginning 1 week after the initial antigen application. ANXA1/ mice stimulated with HDM showed marked exacerbations of airway hyperreactivity (AHR), eosinophil accumulation, subepithelial fibrosis, and mucus hypersecretion, all parameters correlating with overexpression of cytokines (IL-4, IL-13, TNF- , and TGF- ) and chemokines (CCL11/eotaxin-1 and CCL2/MCP-1). Intranasal treatment with peptide Ac2-26 decreased eosinophil infiltration, peribronchiolar fibrosis, and mucus exacerbation caused by the allergen challenge. Ac2-26 also inhibited AHR and mediator production. Collectively, our findings show that the AnxA1-derived peptide Ac2-26 protects against several pathological changes associated with HDM allergic reaction, suggesting that this peptide or related AnxA1-mimetic Ac2-26 may represent promising therapeutic candidates for the treatment of allergic asthma.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/51734/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALTatianaFerreira_MarcoAMartins_etal_IOC_2022.pdfTatianaFerreira_MarcoAMartins_etal_IOC_2022.pdfapplication/pdf3792986https://www.arca.fiocruz.br/bitstream/icict/51734/2/TatianaFerreira_MarcoAMartins_etal_IOC_2022.pdfd8608a7cc6ca9ca8d5254aaa0fd86bdfMD52icict/517342022-03-17 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| dc.title.pt_BR.fl_str_mv |
Annexin-A1-Derived Peptide Ac2-26 Suppresses Allergic Airway Inflammation and Remodelling in Mice |
| title |
Annexin-A1-Derived Peptide Ac2-26 Suppresses Allergic Airway Inflammation and Remodelling in Mice |
| spellingShingle |
Annexin-A1-Derived Peptide Ac2-26 Suppresses Allergic Airway Inflammation and Remodelling in Mice Ferreira, Tatiana Paula Teixeira Pulmão Inflamação Remodelação Asma alérgica Terapia Peptídeo Ac2-26 Lung Inflammation Remodelling Allergic asthma Therapy peptide Ac2-26 |
| title_short |
Annexin-A1-Derived Peptide Ac2-26 Suppresses Allergic Airway Inflammation and Remodelling in Mice |
| title_full |
Annexin-A1-Derived Peptide Ac2-26 Suppresses Allergic Airway Inflammation and Remodelling in Mice |
| title_fullStr |
Annexin-A1-Derived Peptide Ac2-26 Suppresses Allergic Airway Inflammation and Remodelling in Mice |
| title_full_unstemmed |
Annexin-A1-Derived Peptide Ac2-26 Suppresses Allergic Airway Inflammation and Remodelling in Mice |
| title_sort |
Annexin-A1-Derived Peptide Ac2-26 Suppresses Allergic Airway Inflammation and Remodelling in Mice |
| author |
Ferreira, Tatiana Paula Teixeira |
| author_facet |
Ferreira, Tatiana Paula Teixeira Guimarães, Fernanda Verdini Sá, Yago Amigo Pinho Jannini Ribeiro, Natalia Barreto da Silva Arantes, Ana Carolina Santos de Carvalho, Vinicius de Frias Sousa, Lirlândia Pires Perretti, Mauro Martins, Marco Aurélio Silva, Patrícia Machado Rodrigues e |
| author_role |
author |
| author2 |
Guimarães, Fernanda Verdini Sá, Yago Amigo Pinho Jannini Ribeiro, Natalia Barreto da Silva Arantes, Ana Carolina Santos de Carvalho, Vinicius de Frias Sousa, Lirlândia Pires Perretti, Mauro Martins, Marco Aurélio Silva, Patrícia Machado Rodrigues e |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Ferreira, Tatiana Paula Teixeira Guimarães, Fernanda Verdini Sá, Yago Amigo Pinho Jannini Ribeiro, Natalia Barreto da Silva Arantes, Ana Carolina Santos de Carvalho, Vinicius de Frias Sousa, Lirlândia Pires Perretti, Mauro Martins, Marco Aurélio Silva, Patrícia Machado Rodrigues e |
| dc.subject.other.pt_BR.fl_str_mv |
Pulmão Inflamação Remodelação Asma alérgica Terapia Peptídeo Ac2-26 |
| topic |
Pulmão Inflamação Remodelação Asma alérgica Terapia Peptídeo Ac2-26 Lung Inflammation Remodelling Allergic asthma Therapy peptide Ac2-26 |
| dc.subject.en.pt_BR.fl_str_mv |
Lung Inflammation Remodelling Allergic asthma Therapy peptide Ac2-26 |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. |
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2022 |
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2022-03-17T20:33:28Z |
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2022-03-17T20:33:28Z |
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2022 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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FERREIRA, Tatiana Paula Teixeira et al. Annexin-A1-Derived Peptide Ac2-26 Suppresses Allergic Airway Inflammation and Remodelling in Mice. Cells, v. 11, n. 759, p. 1 - 13, Feb. 2022. |
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https://www.arca.fiocruz.br/handle/icict/51734 |
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2073-4409 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/cells11050759 |
| identifier_str_mv |
FERREIRA, Tatiana Paula Teixeira et al. Annexin-A1-Derived Peptide Ac2-26 Suppresses Allergic Airway Inflammation and Remodelling in Mice. Cells, v. 11, n. 759, p. 1 - 13, Feb. 2022. 2073-4409 10.3390/cells11050759 |
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