NFAT1 Transcription Factor Regulates Pulmonary Allergic Inflammation and Airway Responsiveness
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2009 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/28983 |
Resumo: | Instituto Nacional de Câncer. Divisão de Biologia Celular. Rio de Janeiro, RJ, Brasil. |
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Fonseca, Bruna P. F.Olsen, Priscilla C.Coelho, Luciana PFerreira, Tatiana P. T.Souza, Heitor S.Martins, Marco AurélioViola, João P. B.2018-09-22T00:15:37Z2018-09-22T00:15:37Z2009FONSECA, Bruna P. F. et al. NFAT1 Transcription Factor Regulates Pulmonary Allergic Inflammation and Airway Responsiveness. Am J Respir Cell Mol Biol., v. 40. p 66–75, 2009.1044-1549https://www.arca.fiocruz.br/handle/icict/289831535-4989engAmerican Thoracic Societyalergia respiratóriaasmaresposta imunepulmãoallergic inflammationasthmaNAFT1immune responselungNFAT1 Transcription Factor Regulates Pulmonary Allergic Inflammation and Airway Responsivenessinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto Nacional de Câncer. Divisão de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Laboratório Multidisciplinar. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Câncer. Divisão de Biologia Celular. Rio de Janeiro, RJ, Brasil.Allergic asthma is a chronic inflammatory disease of the lung whose incidence and morbidity continues to rise in developed nations. Despitebeingahallmarkofasthma,themolecularmechanismsthat determine airway hyperresponsiveness (AHR) are not completely established. Transcription factors of the NFAT family are involved in the regulation of several asthma-related genes. It has been shown thattheabsenceofNFAT1leadstoanincreasedpleuraleosinophilic allergic response accompanied by an increased production of Th2 cytokines, suggesting a role for NFAT1 in the regulation of allergic diseases. Herein, we analyze NFAT12/2 mice to address the role of NFAT1inamodelofallergicairwayinflammationanditsinfluencein AHR. NFAT12/2 mice submitted to airway inflammation display a significant exacerbation of several features of the allergic disease, including lung inflammation, eosinophilia, and serum IgE levels, which were concomitant with elevated Th2 cytokine production. However, in spite of the increased allergic phenotype, NFAT12/2 mice failed to express AHR after methacholine aerosol. Refractoriness of NFAT12/2 mice to methacholine was confirmed in naı ¨ve mice, suggesting that this refractoriness occurs in an intrinsic way, independentofthelunginflammation.Inaddition,NFAT12/2mice exhibit increased AHR in response to serotonin inhalation, suggesting a specific role for NFAT1 in the methacholine pathway of bronchoconstriction. Taken together, these data add support to the interpretation that NFAT1 acts as a counterregulatory mechanism to suppress allergic inflammation. Moreover, our findings suggest a novel role for NFAT1 protein in airway responsiveness mediated by the cholinergic pathway.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28983/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALluciana_coelho_etal_IOC_2009.pdfluciana_coelho_etal_IOC_2009.pdfapplication/pdf571588https://www.arca.fiocruz.br/bitstream/icict/28983/2/luciana_coelho_etal_IOC_2009.pdf7957a1cca5fbefdfb65220689b3ac19aMD52TEXTluciana_coelho_etal_IOC_2009.pdf.txtluciana_coelho_etal_IOC_2009.pdf.txtExtracted texttext/plain60289https://www.arca.fiocruz.br/bitstream/icict/28983/3/luciana_coelho_etal_IOC_2009.pdf.txt009bd677dc8f48506493d7be3aa00a31MD53icict/289832018-09-22 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| dc.title.pt_BR.fl_str_mv |
NFAT1 Transcription Factor Regulates Pulmonary Allergic Inflammation and Airway Responsiveness |
| title |
NFAT1 Transcription Factor Regulates Pulmonary Allergic Inflammation and Airway Responsiveness |
| spellingShingle |
NFAT1 Transcription Factor Regulates Pulmonary Allergic Inflammation and Airway Responsiveness Fonseca, Bruna P. F. alergia respiratória asma resposta imune pulmão allergic inflammation asthma NAFT1 immune response lung |
| title_short |
NFAT1 Transcription Factor Regulates Pulmonary Allergic Inflammation and Airway Responsiveness |
| title_full |
NFAT1 Transcription Factor Regulates Pulmonary Allergic Inflammation and Airway Responsiveness |
| title_fullStr |
NFAT1 Transcription Factor Regulates Pulmonary Allergic Inflammation and Airway Responsiveness |
| title_full_unstemmed |
NFAT1 Transcription Factor Regulates Pulmonary Allergic Inflammation and Airway Responsiveness |
| title_sort |
NFAT1 Transcription Factor Regulates Pulmonary Allergic Inflammation and Airway Responsiveness |
| author |
Fonseca, Bruna P. F. |
| author_facet |
Fonseca, Bruna P. F. Olsen, Priscilla C. Coelho, Luciana P Ferreira, Tatiana P. T. Souza, Heitor S. Martins, Marco Aurélio Viola, João P. B. |
| author_role |
author |
| author2 |
Olsen, Priscilla C. Coelho, Luciana P Ferreira, Tatiana P. T. Souza, Heitor S. Martins, Marco Aurélio Viola, João P. B. |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Fonseca, Bruna P. F. Olsen, Priscilla C. Coelho, Luciana P Ferreira, Tatiana P. T. Souza, Heitor S. Martins, Marco Aurélio Viola, João P. B. |
| dc.subject.other.pt_BR.fl_str_mv |
alergia respiratória asma resposta imune pulmão |
| topic |
alergia respiratória asma resposta imune pulmão allergic inflammation asthma NAFT1 immune response lung |
| dc.subject.en.pt_BR.fl_str_mv |
allergic inflammation asthma NAFT1 immune response lung |
| description |
Instituto Nacional de Câncer. Divisão de Biologia Celular. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2009 |
| dc.date.issued.fl_str_mv |
2009 |
| dc.date.accessioned.fl_str_mv |
2018-09-22T00:15:37Z |
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2018-09-22T00:15:37Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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FONSECA, Bruna P. F. et al. NFAT1 Transcription Factor Regulates Pulmonary Allergic Inflammation and Airway Responsiveness. Am J Respir Cell Mol Biol., v. 40. p 66–75, 2009. |
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https://www.arca.fiocruz.br/handle/icict/28983 |
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1044-1549 |
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1535-4989 |
| identifier_str_mv |
FONSECA, Bruna P. F. et al. NFAT1 Transcription Factor Regulates Pulmonary Allergic Inflammation and Airway Responsiveness. Am J Respir Cell Mol Biol., v. 40. p 66–75, 2009. 1044-1549 1535-4989 |
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eng |
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American Thoracic Society |
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American Thoracic Society |
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