Lutzomyia longipalpis saliva triggers lipid body formation and prostaglandin E2 production in murine macrophages
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/1761 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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Santos, Théo de AraújoPrates, Deboraci BritoAndrade, Bruno de BezerrilNascimento, Danielle de OliveiraClarêncio, JorgeEntringer, Petter FCarneiro, Alan BSilva Neto, Mário A. CMiranda, José CarlosBrodskyn, Claudia IdaBarral, Aldina Maria PradoBozza, Patrícia TorresBorges, Valeria de Matos2011-03-26T23:32:40Z2011-03-26T23:32:40Z2010ARAÚJO-SANTOS, T. et al.Lutzomyia longipalpis saliva triggers lipid body formation and prostaglandin E2 production in murine macrophages. PLoS Neglected Tropical Diseases, v.4, n.11, p.e873, 2010.21072234https://www.arca.fiocruz.br/handle/icict/1761engPublic Library of ScienceLutzomya (L.) longipalpisLeishmaniainfantum chagasiSalivaResposta inflamatoriaProstaglandina E2Proteínas e Peptídeos SalivaresDinoprostonaMacrofagosLeishmania infantumGlandulas salivaresLutzomyia longipalpis saliva triggers lipid body formation and prostaglandin E2 production in murine macrophagesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro, BrasilInstituto Nacional de Ciência e Tecnologia. São Paulo, SP, BrasilAfter the injection of saliva into the host's skin by sand flies, a transient erythematous reaction is observed, which is related to an influx of inflammatory cells and the release of various molecules that actively facilitate the blood meal. It is important to understand the specific mechanisms by which sand fly saliva manipulates the host's inflammatory responses. Herein, we report that saliva from Lutzomyia (L.) longipalpis, a widespread Leishmania vector, induces early production of eicosanoids. Intense formation of intracellular organelles called lipid bodies (LBs) was noted within those cells that migrated to the site of saliva injection. In vitro and ex vivo, sand fly saliva was able to induce LB formation and PGE2 release by macrophages. Interestingly, PGE2 production induced by L. longipalpis saliva was dependent on intracellular mechanisms involving phosphorylation of signaling proteins such as PKC-α and ERK-1/2 and subsequent activation of cyclooxygenase-2. Thus, this study provides new insights into the pharmacological properties of sand fly saliva and opens new opportunities for intervening with the induction of the host's inflammatory pathways by L. longipalpis bites.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALLutzomyia longipalpis Saliva Triggers Lipid Body Formation and Prostaglandin E2 Production in Murine Macrophages.pdfLutzomyia longipalpis Saliva Triggers Lipid Body Formation and Prostaglandin E2 Production in Murine Macrophages.pdfapplication/pdf579593https://www.arca.fiocruz.br/bitstream/icict/1761/1/Lutzomyia%20longipalpis%20Saliva%20Triggers%20Lipid%20Body%20Formation%20and%20Prostaglandin%20E2%20Production%20in%20Murine%20Macrophages.pdf108b97d770844c5bec2f062e0883205fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://www.arca.fiocruz.br/bitstream/icict/1761/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTLutzomyia longipalpis Saliva Triggers Lipid Body Formation and Prostaglandin E2 Production in Murine Macrophages.pdf.txtLutzomyia longipalpis Saliva Triggers Lipid Body Formation and Prostaglandin E2 Production in Murine Macrophages.pdf.txtExtracted texttext/plain44384https://www.arca.fiocruz.br/bitstream/icict/1761/5/Lutzomyia%20longipalpis%20Saliva%20Triggers%20Lipid%20Body%20Formation%20and%20Prostaglandin%20E2%20Production%20in%20Murine%20Macrophages.pdf.txt123e5abb30a9313f98ad055dfaf53f9bMD55THUMBNAILLutzomyia longipalpis Saliva Triggers Lipid Body Formation and Prostaglandin E2 Production in Murine Macrophages.pdf.jpgLutzomyia longipalpis Saliva Triggers Lipid Body Formation and Prostaglandin E2 Production in Murine Macrophages.pdf.jpgGenerated Thumbnailimage/jpeg2639https://www.arca.fiocruz.br/bitstream/icict/1761/4/Lutzomyia%20longipalpis%20Saliva%20Triggers%20Lipid%20Body%20Formation%20and%20Prostaglandin%20E2%20Production%20in%20Murine%20Macrophages.pdf.jpg6dc34393ae53e1bade3d5570d5da3119MD54icict/17612023-03-15 14:33:08.691oai:www.arca.fiocruz.br:icict/1761Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:08Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Lutzomyia longipalpis saliva triggers lipid body formation and prostaglandin E2 production in murine macrophages |
| title |
Lutzomyia longipalpis saliva triggers lipid body formation and prostaglandin E2 production in murine macrophages |
| spellingShingle |
Lutzomyia longipalpis saliva triggers lipid body formation and prostaglandin E2 production in murine macrophages Santos, Théo de Araújo Lutzomya (L.) longipalpis Leishmaniainfantum chagasi Saliva Resposta inflamatoria Prostaglandina E2 Proteínas e Peptídeos Salivares Dinoprostona Macrofagos Leishmania infantum Glandulas salivares |
| title_short |
Lutzomyia longipalpis saliva triggers lipid body formation and prostaglandin E2 production in murine macrophages |
| title_full |
Lutzomyia longipalpis saliva triggers lipid body formation and prostaglandin E2 production in murine macrophages |
| title_fullStr |
Lutzomyia longipalpis saliva triggers lipid body formation and prostaglandin E2 production in murine macrophages |
| title_full_unstemmed |
Lutzomyia longipalpis saliva triggers lipid body formation and prostaglandin E2 production in murine macrophages |
| title_sort |
Lutzomyia longipalpis saliva triggers lipid body formation and prostaglandin E2 production in murine macrophages |
| author |
Santos, Théo de Araújo |
| author_facet |
Santos, Théo de Araújo Prates, Deboraci Brito Andrade, Bruno de Bezerril Nascimento, Danielle de Oliveira Clarêncio, Jorge Entringer, Petter F Carneiro, Alan B Silva Neto, Mário A. C Miranda, José Carlos Brodskyn, Claudia Ida Barral, Aldina Maria Prado Bozza, Patrícia Torres Borges, Valeria de Matos |
| author_role |
author |
| author2 |
Prates, Deboraci Brito Andrade, Bruno de Bezerril Nascimento, Danielle de Oliveira Clarêncio, Jorge Entringer, Petter F Carneiro, Alan B Silva Neto, Mário A. C Miranda, José Carlos Brodskyn, Claudia Ida Barral, Aldina Maria Prado Bozza, Patrícia Torres Borges, Valeria de Matos |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Santos, Théo de Araújo Prates, Deboraci Brito Andrade, Bruno de Bezerril Nascimento, Danielle de Oliveira Clarêncio, Jorge Entringer, Petter F Carneiro, Alan B Silva Neto, Mário A. C Miranda, José Carlos Brodskyn, Claudia Ida Barral, Aldina Maria Prado Bozza, Patrícia Torres Borges, Valeria de Matos |
| dc.subject.other.pt_BR.fl_str_mv |
Lutzomya (L.) longipalpis Leishmaniainfantum chagasi Saliva Resposta inflamatoria Prostaglandina E2 |
| topic |
Lutzomya (L.) longipalpis Leishmaniainfantum chagasi Saliva Resposta inflamatoria Prostaglandina E2 Proteínas e Peptídeos Salivares Dinoprostona Macrofagos Leishmania infantum Glandulas salivares |
| dc.subject.decs.pt_BR.fl_str_mv |
Proteínas e Peptídeos Salivares Dinoprostona Macrofagos Leishmania infantum Glandulas salivares |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
| publishDate |
2010 |
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2010 |
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2011-03-26T23:32:40Z |
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2011-03-26T23:32:40Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
ARAÚJO-SANTOS, T. et al.Lutzomyia longipalpis saliva triggers lipid body formation and prostaglandin E2 production in murine macrophages. PLoS Neglected Tropical Diseases, v.4, n.11, p.e873, 2010. |
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https://www.arca.fiocruz.br/handle/icict/1761 |
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21072234 |
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ARAÚJO-SANTOS, T. et al.Lutzomyia longipalpis saliva triggers lipid body formation and prostaglandin E2 production in murine macrophages. PLoS Neglected Tropical Diseases, v.4, n.11, p.e873, 2010. 21072234 |
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openAccess |
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Public Library of Science |
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Public Library of Science |
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