Lutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infection
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/27538 |
Resumo: | Fundação Oswaldo Cruz. Teresina, PI, Brasil |
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Teixeira, Clarissa RomeroSantos, Claire da SilvaPrates, Deboraci BritoSantos, Rafael Teixeira Tibúrcio dosSantos, Théo de AraújoSouza Neto, Sebastião Martins deBorges, Valéria de MatosBarral Netto, ManoelBrodskyn, Claudia Ida2018-07-16T13:35:49Z2018-07-16T13:35:49Z2018TEIXEIRA, C. R. et al. Lutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infection. Frontiers in Microbiology, v. 9, art. 881, 2018.1664-302Xhttps://www.arca.fiocruz.br/handle/icict/2753810.3389/fmicb.2018.00881engFrontiers MediaLutzomyia longipalpisSaliva da mosca da areiaLeishmania infantumIL-17NeutrófilosMacrófagosLutzomyia longipalpisSand fly salivaLeishmania infantumIL-17NeutrophilsMacrophagesLutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Teresina, PI, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamentos de Biomorfologia e Biointeração. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal do Oeste da Bahia. Centro de Ciências Biológicas e Saúde. Barreiras, BA, BrasilUniversidade Federal da Grande Dourados. Faculdade de Ciências da Saúde. Dourados, MGS, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Departamento de Patologia e Medicina Legal. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. São Paulo, SP, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamentos de Biomorfologia e Biointeração. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. São Paulo, SP, BrasilDuring bloodfeeding, the presence of sand fly saliva in the hemorrhagic pool where Leishmania is also inoculated modulates the development of host immune mechanisms creating a favorable environment for disease progression. To date, information obtained through experimental models suggests that sand fly saliva induces cellular recruitment and modulates production of eicosanoids. However, the effect of sand fly saliva in the different steps of the inflammatory response triggered by Leishmania remains undefined. Here we further investigate if interaction of Lutzomyia longipalpis salivary gland sonicate (SGS) with different host cells present during the initial inflammatory events regulate Leishmania infantum infectivity. Initially, we observed that incubation of human peripheral blood mononuclear cells (PBMC) with Lu. longipalpis SGS in the presence of L. infantum significantly increased IL-10 but did not alter expression of IFN-γ and TNF-α by CD4+ T cells induced by the parasite alone. Interestingly, incubation of PBMC with Lu. longipalpis SGS alone or in the presence of L. infantum resulted in increased IL-17 production. The presence of IL-17 is related to neutrophil recruitment and plays an important role at the site of infection. Here, we also observed increased migration of neutrophil using an in vitro chemotactic assay following incubation with supernatants from PBMC stimulated with L. infantum and Lu. longipalpis SGS. Neutrophil migration was abrogated following neutralization of IL-17 with specific antibodies. Moreover, culture of human neutrophils with L. infantum in the presence of Lu. longipalpis SGS promoted neutrophil apoptosis resulting in increased parasite viability. Neutrophils operate as the first line of defense in the early stages of infection and later interact with different cells, such as macrophages. The crosstalk between neutrophils and macrophages is critical to determine the type of specific immune response that will develop. Here, we observed that co-culture of human macrophages with autologous neutrophils previously infected in the presence of Lu. longipalpis SGS resulted in a higher infection rate, accompanied by increased production of TGF-β and PGE2. Our results provide new insight into the contribution of Lu. longipalpis SGS to L. infantum-induced regulation of important inflammatory events, creating a favorable environment for parasite survival inside different host cells.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/27538/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALTeixeira CR Lutzomyia longipalpis Saliva Drives Interleukin....pdfTeixeira CR Lutzomyia longipalpis Saliva Drives Interleukin....pdfapplication/pdf1277677https://www.arca.fiocruz.br/bitstream/icict/27538/2/Teixeira%20CR%20Lutzomyia%20longipalpis%20Saliva%20Drives%20Interleukin....pdff437f4c101598f03ccaa01ea8afd2c7aMD52TEXTTeixeira CR Lutzomyia longipalpis Saliva Drives Interleukin....pdf.txtTeixeira CR Lutzomyia longipalpis Saliva Drives Interleukin....pdf.txtExtracted texttext/plain54961https://www.arca.fiocruz.br/bitstream/icict/27538/3/Teixeira%20CR%20Lutzomyia%20longipalpis%20Saliva%20Drives%20Interleukin....pdf.txt3142a925f53c09871a4cfc232f53d143MD53icict/275382023-03-15 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dc.title.pt_BR.fl_str_mv |
Lutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infection |
title |
Lutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infection |
spellingShingle |
Lutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infection Teixeira, Clarissa Romero Lutzomyia longipalpis Saliva da mosca da areia Leishmania infantum IL-17 Neutrófilos Macrófagos Lutzomyia longipalpis Sand fly saliva Leishmania infantum IL-17 Neutrophils Macrophages |
title_short |
Lutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infection |
title_full |
Lutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infection |
title_fullStr |
Lutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infection |
title_full_unstemmed |
Lutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infection |
title_sort |
Lutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infection |
author |
Teixeira, Clarissa Romero |
author_facet |
Teixeira, Clarissa Romero Santos, Claire da Silva Prates, Deboraci Brito Santos, Rafael Teixeira Tibúrcio dos Santos, Théo de Araújo Souza Neto, Sebastião Martins de Borges, Valéria de Matos Barral Netto, Manoel Brodskyn, Claudia Ida |
author_role |
author |
author2 |
Santos, Claire da Silva Prates, Deboraci Brito Santos, Rafael Teixeira Tibúrcio dos Santos, Théo de Araújo Souza Neto, Sebastião Martins de Borges, Valéria de Matos Barral Netto, Manoel Brodskyn, Claudia Ida |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Teixeira, Clarissa Romero Santos, Claire da Silva Prates, Deboraci Brito Santos, Rafael Teixeira Tibúrcio dos Santos, Théo de Araújo Souza Neto, Sebastião Martins de Borges, Valéria de Matos Barral Netto, Manoel Brodskyn, Claudia Ida |
dc.subject.other.pt_BR.fl_str_mv |
Lutzomyia longipalpis Saliva da mosca da areia Leishmania infantum IL-17 Neutrófilos Macrófagos |
topic |
Lutzomyia longipalpis Saliva da mosca da areia Leishmania infantum IL-17 Neutrófilos Macrófagos Lutzomyia longipalpis Sand fly saliva Leishmania infantum IL-17 Neutrophils Macrophages |
dc.subject.en.pt_BR.fl_str_mv |
Lutzomyia longipalpis Sand fly saliva Leishmania infantum IL-17 Neutrophils Macrophages |
description |
Fundação Oswaldo Cruz. Teresina, PI, Brasil |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-07-16T13:35:49Z |
dc.date.available.fl_str_mv |
2018-07-16T13:35:49Z |
dc.date.issued.fl_str_mv |
2018 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
TEIXEIRA, C. R. et al. Lutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infection. Frontiers in Microbiology, v. 9, art. 881, 2018. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/27538 |
dc.identifier.issn.pt_BR.fl_str_mv |
1664-302X |
dc.identifier.doi.none.fl_str_mv |
10.3389/fmicb.2018.00881 |
identifier_str_mv |
TEIXEIRA, C. R. et al. Lutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infection. Frontiers in Microbiology, v. 9, art. 881, 2018. 1664-302X 10.3389/fmicb.2018.00881 |
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https://www.arca.fiocruz.br/handle/icict/27538 |
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eng |
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eng |
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Frontiers Media |
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Frontiers Media |
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