Lutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infection

Detalhes bibliográficos
Autor(a) principal: Teixeira, Clarissa Romero
Data de Publicação: 2018
Outros Autores: Santos, Claire da Silva, Prates, Deboraci Brito, Santos, Rafael Teixeira Tibúrcio dos, Santos, Théo de Araújo, Souza Neto, Sebastião Martins de, Borges, Valéria de Matos, Barral Netto, Manoel, Brodskyn, Claudia Ida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/27538
Resumo: Fundação Oswaldo Cruz. Teresina, PI, Brasil
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spelling Teixeira, Clarissa RomeroSantos, Claire da SilvaPrates, Deboraci BritoSantos, Rafael Teixeira Tibúrcio dosSantos, Théo de AraújoSouza Neto, Sebastião Martins deBorges, Valéria de MatosBarral Netto, ManoelBrodskyn, Claudia Ida2018-07-16T13:35:49Z2018-07-16T13:35:49Z2018TEIXEIRA, C. R. et al. Lutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infection. Frontiers in Microbiology, v. 9, art. 881, 2018.1664-302Xhttps://www.arca.fiocruz.br/handle/icict/2753810.3389/fmicb.2018.00881engFrontiers MediaLutzomyia longipalpisSaliva da mosca da areiaLeishmania infantumIL-17NeutrófilosMacrófagosLutzomyia longipalpisSand fly salivaLeishmania infantumIL-17NeutrophilsMacrophagesLutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Teresina, PI, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamentos de Biomorfologia e Biointeração. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal do Oeste da Bahia. Centro de Ciências Biológicas e Saúde. Barreiras, BA, BrasilUniversidade Federal da Grande Dourados. Faculdade de Ciências da Saúde. Dourados, MGS, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Departamento de Patologia e Medicina Legal. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. São Paulo, SP, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamentos de Biomorfologia e Biointeração. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. São Paulo, SP, BrasilDuring bloodfeeding, the presence of sand fly saliva in the hemorrhagic pool where Leishmania is also inoculated modulates the development of host immune mechanisms creating a favorable environment for disease progression. To date, information obtained through experimental models suggests that sand fly saliva induces cellular recruitment and modulates production of eicosanoids. However, the effect of sand fly saliva in the different steps of the inflammatory response triggered by Leishmania remains undefined. Here we further investigate if interaction of Lutzomyia longipalpis salivary gland sonicate (SGS) with different host cells present during the initial inflammatory events regulate Leishmania infantum infectivity. Initially, we observed that incubation of human peripheral blood mononuclear cells (PBMC) with Lu. longipalpis SGS in the presence of L. infantum significantly increased IL-10 but did not alter expression of IFN-γ and TNF-α by CD4+ T cells induced by the parasite alone. Interestingly, incubation of PBMC with Lu. longipalpis SGS alone or in the presence of L. infantum resulted in increased IL-17 production. The presence of IL-17 is related to neutrophil recruitment and plays an important role at the site of infection. Here, we also observed increased migration of neutrophil using an in vitro chemotactic assay following incubation with supernatants from PBMC stimulated with L. infantum and Lu. longipalpis SGS. Neutrophil migration was abrogated following neutralization of IL-17 with specific antibodies. Moreover, culture of human neutrophils with L. infantum in the presence of Lu. longipalpis SGS promoted neutrophil apoptosis resulting in increased parasite viability. Neutrophils operate as the first line of defense in the early stages of infection and later interact with different cells, such as macrophages. The crosstalk between neutrophils and macrophages is critical to determine the type of specific immune response that will develop. Here, we observed that co-culture of human macrophages with autologous neutrophils previously infected in the presence of Lu. longipalpis SGS resulted in a higher infection rate, accompanied by increased production of TGF-β and PGE2. Our results provide new insight into the contribution of Lu. longipalpis SGS to L. infantum-induced regulation of important inflammatory events, creating a favorable environment for parasite survival inside different host cells.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/27538/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALTeixeira CR Lutzomyia longipalpis Saliva Drives Interleukin....pdfTeixeira CR Lutzomyia longipalpis Saliva Drives Interleukin....pdfapplication/pdf1277677https://www.arca.fiocruz.br/bitstream/icict/27538/2/Teixeira%20CR%20Lutzomyia%20longipalpis%20Saliva%20Drives%20Interleukin....pdff437f4c101598f03ccaa01ea8afd2c7aMD52TEXTTeixeira CR Lutzomyia longipalpis Saliva Drives Interleukin....pdf.txtTeixeira CR Lutzomyia longipalpis Saliva Drives 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dc.title.pt_BR.fl_str_mv Lutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infection
title Lutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infection
spellingShingle Lutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infection
Teixeira, Clarissa Romero
Lutzomyia longipalpis
Saliva da mosca da areia
Leishmania infantum
IL-17
Neutrófilos
Macrófagos
Lutzomyia longipalpis
Sand fly saliva
Leishmania infantum
IL-17
Neutrophils
Macrophages
title_short Lutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infection
title_full Lutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infection
title_fullStr Lutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infection
title_full_unstemmed Lutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infection
title_sort Lutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infection
author Teixeira, Clarissa Romero
author_facet Teixeira, Clarissa Romero
Santos, Claire da Silva
Prates, Deboraci Brito
Santos, Rafael Teixeira Tibúrcio dos
Santos, Théo de Araújo
Souza Neto, Sebastião Martins de
Borges, Valéria de Matos
Barral Netto, Manoel
Brodskyn, Claudia Ida
author_role author
author2 Santos, Claire da Silva
Prates, Deboraci Brito
Santos, Rafael Teixeira Tibúrcio dos
Santos, Théo de Araújo
Souza Neto, Sebastião Martins de
Borges, Valéria de Matos
Barral Netto, Manoel
Brodskyn, Claudia Ida
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Teixeira, Clarissa Romero
Santos, Claire da Silva
Prates, Deboraci Brito
Santos, Rafael Teixeira Tibúrcio dos
Santos, Théo de Araújo
Souza Neto, Sebastião Martins de
Borges, Valéria de Matos
Barral Netto, Manoel
Brodskyn, Claudia Ida
dc.subject.other.pt_BR.fl_str_mv Lutzomyia longipalpis
Saliva da mosca da areia
Leishmania infantum
IL-17
Neutrófilos
Macrófagos
topic Lutzomyia longipalpis
Saliva da mosca da areia
Leishmania infantum
IL-17
Neutrófilos
Macrófagos
Lutzomyia longipalpis
Sand fly saliva
Leishmania infantum
IL-17
Neutrophils
Macrophages
dc.subject.en.pt_BR.fl_str_mv Lutzomyia longipalpis
Sand fly saliva
Leishmania infantum
IL-17
Neutrophils
Macrophages
description Fundação Oswaldo Cruz. Teresina, PI, Brasil
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-07-16T13:35:49Z
dc.date.available.fl_str_mv 2018-07-16T13:35:49Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TEIXEIRA, C. R. et al. Lutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infection. Frontiers in Microbiology, v. 9, art. 881, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/27538
dc.identifier.issn.pt_BR.fl_str_mv 1664-302X
dc.identifier.doi.none.fl_str_mv 10.3389/fmicb.2018.00881
identifier_str_mv TEIXEIRA, C. R. et al. Lutzomyia longipalpis Saliva Drives Interleukin-17-Induced Neutrophil Recruitment Favoring Leishmania infantum Infection. Frontiers in Microbiology, v. 9, art. 881, 2018.
1664-302X
10.3389/fmicb.2018.00881
url https://www.arca.fiocruz.br/handle/icict/27538
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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