Change in vitamin D levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settings

Detalhes bibliográficos
Autor(a) principal: Havers, Fiona P.
Data de Publicação: 2014
Outros Autores: Detrick, Barbara, Cardoso, Sandra Wagner, Berendes, Sima, Lama, Javier R., Sugandhavesa, Patcharaphan, Mwelase, Noluthando H., Campbell, Thomas B., Gupta, Amita
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10735
Resumo: AIDS Clinical Trials Group, US National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Boehringer-Ingelheim, Bristol-Myers Squibb, Gilead Sciences, GlaxoSmithKline
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spelling Havers, Fiona P.Detrick, BarbaraCardoso, Sandra WagnerBerendes, SimaLama, Javier R.Sugandhavesa, PatcharaphanMwelase, Noluthando H.Campbell, Thomas B.Gupta, Amita2015-06-08T16:50:13Z2015-06-08T16:50:13Z2014HAVERS, Fiona P. et al. Change in vitamin D levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settings. Plos One, v. 9, n. 4, p. 1-9, 2014.1932-6203https://www.arca.fiocruz.br/handle/icict/1073510.1371/journal.pone.00951641932-6203AIDS Clinical Trials Group, US National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Boehringer-Ingelheim, Bristol-Myers Squibb, Gilead Sciences, GlaxoSmithKlineJohns Hopkins University School of Medicine. Baltimore, MD, United States of America / Johns Hopkins University Bloomberg School of Public Health. Baltimore, MD, United States of America.Johns Hopkins University School of Medicine. Baltimore, MD, United States of America.Fundação Oswaldo cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.College of Medicine-Johns Hopkins University Research Project. Blantyre, Malawi / Liverpool School of Tropical Medicine. Liverpool, United Kingdom.Asociacion Civil Impacta Salud y Educacion. Lima, Peru.Chiang Mai University. Chiang Mai, Thailand.University of Witswatersrand. Johannesburg, South Africa.University of Colorado Denver. Aurora, CO, United States of America.Johns Hopkins University School of Medicine. Baltimore, MD, United States of America / Johns Hopkins University Bloomberg School of Public Health. Baltimore, MD, United States of America.Study Background: Vitamin D has wide-ranging effects on the immune system, and studies suggest that low serum vitamin D levels are associated with worse clinical outcomes in HIV. Recent studies have identified an interaction between antiretrovirals used to treat HIV and reduced serum vitamin D levels, but these studies have been done in North American and European populations. Methods: Using a prospective cohort study design nested in a multinational clinical trial, we examined the effect of three combination antiretroviral (cART) regimens on serum vitamin D levels in 270 cART-naı¨ve, HIV-infected adults in nine diverse countries, (Brazil, Haiti, Peru, Thailand, India, Malawi, South Africa, Zimbabwe and the United States). We evaluated the change between baseline serum vitamin D levels and vitamin D levels 24 and 48 weeks after cART initiation. Results: Serum vitamin D levels decreased significantly from baseline to 24 weeks among those randomized to efavirenz/lamivudine/zidovudine (mean change: 27.94 [95% Confidence Interval (CI) 210.42, 25.54] ng/ml) and efavirenz/ emtricitabine/tenofovir-DF (mean change: 26.66 [95% CI 29.40, 23.92] ng/ml) when compared to those randomized to atazanavir/emtricitabine/didanosine-EC (mean change: 22.29 [95% CI –4.83, 0.25] ng/ml). Vitamin D levels did not change significantly between week 24 and 48. Other factors that significantly affected serum vitamin D change included country (p,0.001), season (p,0.001) and baseline vitamin D level (p,0.001). Conclusion: Efavirenz-containing cART regimens adversely affected vitamin D levels in patients from economically, geographically and racially diverse resource-limited settings. This effect was most pronounced early after cART initiation. Research is needed to define the role of Vitamin D supplementation in HIV care.engPublic Library of ScienceChange in vitamin D levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settingsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleVitamin DAntiretroviral TherapyHIVStatistical AnalysisHighly ActiveVitamina DTerapia Antirretroviral de Alta AtividadeHIVAnálise Estatísticainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10735/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALChange in vitamin d levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settings.pdfChange in vitamin d levels occurs early after antiretroviral therapy initiation and depends 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dc.title.pt_BR.fl_str_mv Change in vitamin D levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settings
title Change in vitamin D levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settings
spellingShingle Change in vitamin D levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settings
Havers, Fiona P.
Vitamin D
Antiretroviral Therapy
HIV
Statistical Analysis
Highly Active
Vitamina D
Terapia Antirretroviral de Alta Atividade
HIV
Análise Estatística
title_short Change in vitamin D levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settings
title_full Change in vitamin D levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settings
title_fullStr Change in vitamin D levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settings
title_full_unstemmed Change in vitamin D levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settings
title_sort Change in vitamin D levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settings
author Havers, Fiona P.
author_facet Havers, Fiona P.
Detrick, Barbara
Cardoso, Sandra Wagner
Berendes, Sima
Lama, Javier R.
Sugandhavesa, Patcharaphan
Mwelase, Noluthando H.
Campbell, Thomas B.
Gupta, Amita
author_role author
author2 Detrick, Barbara
Cardoso, Sandra Wagner
Berendes, Sima
Lama, Javier R.
Sugandhavesa, Patcharaphan
Mwelase, Noluthando H.
Campbell, Thomas B.
Gupta, Amita
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Havers, Fiona P.
Detrick, Barbara
Cardoso, Sandra Wagner
Berendes, Sima
Lama, Javier R.
Sugandhavesa, Patcharaphan
Mwelase, Noluthando H.
Campbell, Thomas B.
Gupta, Amita
dc.subject.en.pt_BR.fl_str_mv Vitamin D
Antiretroviral Therapy
HIV
Statistical Analysis
Highly Active
topic Vitamin D
Antiretroviral Therapy
HIV
Statistical Analysis
Highly Active
Vitamina D
Terapia Antirretroviral de Alta Atividade
HIV
Análise Estatística
dc.subject.decs.pt_BR.fl_str_mv Vitamina D
Terapia Antirretroviral de Alta Atividade
HIV
Análise Estatística
description AIDS Clinical Trials Group, US National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Boehringer-Ingelheim, Bristol-Myers Squibb, Gilead Sciences, GlaxoSmithKline
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-06-08T16:50:13Z
dc.date.available.fl_str_mv 2015-06-08T16:50:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv HAVERS, Fiona P. et al. Change in vitamin D levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settings. Plos One, v. 9, n. 4, p. 1-9, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10735
dc.identifier.issn.none.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0095164
dc.identifier.eissn.none.fl_str_mv 1932-6203
identifier_str_mv HAVERS, Fiona P. et al. Change in vitamin D levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settings. Plos One, v. 9, n. 4, p. 1-9, 2014.
1932-6203
10.1371/journal.pone.0095164
url https://www.arca.fiocruz.br/handle/icict/10735
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/10735/1/license.txt
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