Vitamin D3 supplementation in HIV infection: effectiveness and associations with antiretroviral therapy

Detalhes bibliográficos
Autor(a) principal: Coelho, Lara
Data de Publicação: 2015
Outros Autores: Cardoso, Sandra W., Luz, Paula M., Hoffman, Risa M., Mendonça, Laura, Veloso, Valdiléa G., Currier, Judith S., Grinsztejn, Beatriz, Lake, Jordan E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/29642
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
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spelling Coelho, LaraCardoso, Sandra W.Luz, Paula M.Hoffman, Risa M.Mendonça, LauraVeloso, Valdiléa G.Currier, Judith S.Grinsztejn, BeatrizLake, Jordan E.2018-10-18T18:21:14Z2018-10-18T18:21:14Z2015COELHO, Lara et al. Vitamin D3 supplementation in HIV infection: effectiveness and associations with antiretroviral therapy. Nutrition Journal, v. 14, p. 1-9, 2015.1475-2891https://www.arca.fiocruz.br/handle/icict/2964210.1186/s12937-015-0072-6engVitamin D3 supplementation in HIV infection: effectiveness and associations with antiretroviral therapyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.University of California. Los Angeles, CA, USA.Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.University of California. Los Angeles, CA, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.University of California. Los Angeles, CA, USA.Background: HIV infection and antiretroviral therapy (ART) may create unique risk factors for vitamin D insufficiency, including alterations of vitamin D metabolism by ART. We prospectively compared demographic and clinical parameters between vitamin D sufficient and insufficient HIV-infected (HIV+) adults, and assessed changes in these parameters among insufficient participants following standardized vitamin D supplementation. Methods: HIV+ adults (≥18 years old) with HIV-1 RNA <50 copies/mL on ART were enrolled. Vitamin D sufficiency and insufficiency were defined as 25-hydroxyvitamin D (25(OH)D) ≥30 or <30 ng/mL, respectively. Insufficient participants received open-label vitamin D3 50,000 IU twice weekly for 5 weeks, then 8000 IU twice weekly to complete 24 weeks. The primary endpoint was success or failure to achieve 25(OH)D ≥30 ng/mL at week 24. Results: Ninety-seven participants enrolled (34 vitamin D sufficient, 63 insufficient); 32 % female, 47 % non-White, median age 46 years, ART duration 5 years, CD4+ T lymphocyte count (CD4) 673 cells/mm3 . 25(OH)D repletion was 83 % (95 % CI 71 %–90 %) successful. 25(OH)D levels correlated with both CD4 (r = 0.44, p = 0.01) and time on protease inhibitor (r = −0.35, p = 0.01). After adjusting for age, sex, race, nadir CD4 and baseline 25(OH)D: 1) current use of efavirenz exposure was associated with a 21.1 ng/mL higher week 24 25(OH)D level (p = 0.007), 2) per year use of zidovudine was associated with 7.1 ng/mL reduction in week 24 serum 25(OH)D (p = 0.05) and 3) every 1 ng/mL 25(OH)D increase was associated with a 3.3 cell/mm3 CD4 increase (p = 0.06). Conclusion: Vitamin D3 supplementation was effective in repleting 25(OH)D levels after 24 weeks. Current efavirenz use was positively associated with post-repletion 25(OH)D levels, while greater time on zidovudine was associated with lower post-repletion 25(OH)D levels. The association between improved CD4 recovery and vitamin D repletion suggests a potential benefit of vitamin D supplementation on immunologic recovery during HIV treatment.HIV infectionAntiretroviral therapy (ART)Vitamin DHIV-infected (HIV+)info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/29642/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALVitamin D3 supplementation in HIV infection_Lara_Coelho_etal_INI_Lapclin-AIDS_2015.pdfVitamin D3 supplementation in HIV infection_Lara_Coelho_etal_INI_Lapclin-AIDS_2015.pdfapplication/pdf626656https://www.arca.fiocruz.br/bitstream/icict/29642/2/Vitamin%20D3%20supplementation%20in%20HIV%20infection_Lara_Coelho_etal_INI_Lapclin-AIDS_2015.pdff1ec2e80b538aa112044f99c6d5992daMD52TEXTVitamin D3 supplementation in HIV 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dc.title.pt_BR.fl_str_mv Vitamin D3 supplementation in HIV infection: effectiveness and associations with antiretroviral therapy
title Vitamin D3 supplementation in HIV infection: effectiveness and associations with antiretroviral therapy
spellingShingle Vitamin D3 supplementation in HIV infection: effectiveness and associations with antiretroviral therapy
Coelho, Lara
HIV infection
Antiretroviral therapy (ART)
Vitamin D
HIV-infected (HIV+)
title_short Vitamin D3 supplementation in HIV infection: effectiveness and associations with antiretroviral therapy
title_full Vitamin D3 supplementation in HIV infection: effectiveness and associations with antiretroviral therapy
title_fullStr Vitamin D3 supplementation in HIV infection: effectiveness and associations with antiretroviral therapy
title_full_unstemmed Vitamin D3 supplementation in HIV infection: effectiveness and associations with antiretroviral therapy
title_sort Vitamin D3 supplementation in HIV infection: effectiveness and associations with antiretroviral therapy
author Coelho, Lara
author_facet Coelho, Lara
Cardoso, Sandra W.
Luz, Paula M.
Hoffman, Risa M.
Mendonça, Laura
Veloso, Valdiléa G.
Currier, Judith S.
Grinsztejn, Beatriz
Lake, Jordan E.
author_role author
author2 Cardoso, Sandra W.
Luz, Paula M.
Hoffman, Risa M.
Mendonça, Laura
Veloso, Valdiléa G.
Currier, Judith S.
Grinsztejn, Beatriz
Lake, Jordan E.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Coelho, Lara
Cardoso, Sandra W.
Luz, Paula M.
Hoffman, Risa M.
Mendonça, Laura
Veloso, Valdiléa G.
Currier, Judith S.
Grinsztejn, Beatriz
Lake, Jordan E.
dc.subject.en.none.fl_str_mv HIV infection
Antiretroviral therapy (ART)
Vitamin D
HIV-infected (HIV+)
topic HIV infection
Antiretroviral therapy (ART)
Vitamin D
HIV-infected (HIV+)
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2018-10-18T18:21:14Z
dc.date.available.fl_str_mv 2018-10-18T18:21:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COELHO, Lara et al. Vitamin D3 supplementation in HIV infection: effectiveness and associations with antiretroviral therapy. Nutrition Journal, v. 14, p. 1-9, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/29642
dc.identifier.issn.pt_BR.fl_str_mv 1475-2891
dc.identifier.doi.none.fl_str_mv 10.1186/s12937-015-0072-6
identifier_str_mv COELHO, Lara et al. Vitamin D3 supplementation in HIV infection: effectiveness and associations with antiretroviral therapy. Nutrition Journal, v. 14, p. 1-9, 2015.
1475-2891
10.1186/s12937-015-0072-6
url https://www.arca.fiocruz.br/handle/icict/29642
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/29642/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/29642/2/Vitamin%20D3%20supplementation%20in%20HIV%20infection_Lara_Coelho_etal_INI_Lapclin-AIDS_2015.pdf
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