A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy

Detalhes bibliográficos
Autor(a) principal: Fava, Vinicius M.
Data de Publicação: 2017
Outros Autores: Manry, Jeremy, Cobat, Aurélie, Orlova, Marianna, Van Thuc, Nguyen, Moraes, Milton O., Marques, Carolinne Sales, Stefani, Mariane M. A., Latini, Ana Carla P., Belone, Andrea F., Thai, Vu Hong, Abel, Laurent, Alcaïs, Alexandre, Schurr, Erwin
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/24757
Resumo: Research Institute of the McGill University Health Centre. Program in Infectious Diseases and Immunity in Global Health. Montreal, Quebec, canada / McGill University. The McGill International TB Centre, Departments of Human Genetics and Medicine. Montreal, Quebec, Canada.
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spelling Fava, Vinicius M.Manry, JeremyCobat, AurélieOrlova, MariannaVan Thuc, NguyenMoraes, Milton O.Marques, Carolinne SalesStefani, Mariane M. A.Latini, Ana Carla P.Belone, Andrea F.Thai, Vu HongAbel, LaurentAlcaïs, AlexandreSchurr, Erwin2018-02-08T11:28:23Z2018-02-08T11:28:23Z2017FAVA, Vinicius M. et al. A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy. PLoS Genet., v.13, n.2, e1006637, 16p, Feb. 2017.1553-7390https://www.arca.fiocruz.br/handle/icict/2475710.1371/journal.pgen.10066371553-7404engPublic Library of ScienceHanseníaseFator de riscoRNA Longo não Codificanteinflamatório patológicoLeprosylncRnaRisk factorpathological inflammatoryA genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleResearch Institute of the McGill University Health Centre. Program in Infectious Diseases and Immunity in Global Health. Montreal, Quebec, canada / McGill University. The McGill International TB Centre, Departments of Human Genetics and Medicine. Montreal, Quebec, Canada.Research Institute of the McGill University Health Centre. Program in Infectious Diseases and Immunity in Global Health. Montreal, Quebec, canada / McGill University. The McGill International TB Centre, Departments of Human Genetics and Medicine. Montreal, Quebec, Canada.Institut National de la Santé et de la Recherche Médicale. Laboratory of Human Genetics of Infectious Diseases. Necker Branch. Paris, France / University Paris Descartes. Imagine Institute. Paris, France / Rockefeller University. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. New York, USA.Research Institute of the McGill University Health Centre. Program in Infectious Diseases and Immunity in Global Health. Montreal, Quebec, canada / McGill University. The McGill International TB Centre, Departments of Human Genetics and Medicine. Montreal, Quebec, Canada.Hospital for Dermato-Venerology. Ho Chi Minh City, Vietnam.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.Universidade Federal de Goiás. Instituto de Saúde Pública e Patologia Tropical. Goiânia, GO, BrasilInstituto Lauro de Souza Lima. Bauru, SP. Brasil.Instituto Lauro de Souza Lima. Bauru, SP. Brasil.Hospital for Dermato-Venerology. Ho Chi Minh City, Vietnam.Institut National de la Santé et de la Recherche Médicale. Laboratory of Human Genetics of Infectious Diseases. Necker Branch. Paris, France / University Paris Descartes. Imagine Institute. Paris, France / Rockefeller University. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. New York, USA.Institut National de la Santé et de la Recherche Médicale. Laboratory of Human Genetics of Infectious Diseases. Necker Branch. Paris, France / University Paris Descartes. Imagine Institute. Paris, France / Rockefeller University. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. New York, USA.Research Institute of the McGill University Health Centre. Program in Infectious Diseases and Immunity in Global Health. Montreal, Quebec, canada / McGill University. The McGill International TB Centre, Departments of Human Genetics and Medicine. Montreal, Quebec, Canada.Leprosy Type-1 Reactions (T1Rs) are pathological inflammatory responses that afflict a sub-group of leprosy patients and result in peripheral nerve damage. Here, we employed a family-based GWAS in 221 families with 229 T1R-affect offspring with stepwise replication to identify risk factors for T1R. We discovered, replicated and validated T1R-specific associations with SNPs located in chromosome region 10p21.2. Combined analysis across the three independent samples resulted in strong evidence of association of rs1875147 with T1R (p = 4.5x10-8; OR = 1.54, 95% CI = 1.32-1.80). The T1R-risk locus was restricted to a lncRNA-encoding genomic interval with rs1875147 being an eQTL for the lncRNA. Since a genetic overlap between leprosy and inflammatory bowel disease (IBD) has been detected, we evaluated if the shared genetic control could be traced to the T1R endophenotype. Employing the results of a recent IBD GWAS meta-analysis we found that 10.6% of IBD SNPs available in our dataset shared a common risk-allele with T1R (p = 2.4x10-4). This finding points to a substantial overlap in the genetic control of clinically diverse inflammatory disorders.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24757/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmilton_moraes_etal_IOC_2017.pdfmilton_moraes_etal_IOC_2017.pdfapplication/pdf3018090https://www.arca.fiocruz.br/bitstream/icict/24757/2/milton_moraes_etal_IOC_2017.pdf4f1884a5b459722255f6434f0d7dfe23MD52TEXTmilton_moraes_etal_IOC_2017.pdf.txtmilton_moraes_etal_IOC_2017.pdf.txtExtracted texttext/plain57745https://www.arca.fiocruz.br/bitstream/icict/24757/3/milton_moraes_etal_IOC_2017.pdf.txtb5f513bd2ede104fbc3c354eb949fb3cMD53icict/247572018-08-15 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dc.title.pt_BR.fl_str_mv A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy
title A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy
spellingShingle A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy
Fava, Vinicius M.
Hanseníase
Fator de risco
RNA Longo não Codificante
inflamatório patológico
Leprosy
lncRna
Risk factor
pathological inflammatory
title_short A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy
title_full A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy
title_fullStr A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy
title_full_unstemmed A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy
title_sort A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy
author Fava, Vinicius M.
author_facet Fava, Vinicius M.
Manry, Jeremy
Cobat, Aurélie
Orlova, Marianna
Van Thuc, Nguyen
Moraes, Milton O.
Marques, Carolinne Sales
Stefani, Mariane M. A.
Latini, Ana Carla P.
Belone, Andrea F.
Thai, Vu Hong
Abel, Laurent
Alcaïs, Alexandre
Schurr, Erwin
author_role author
author2 Manry, Jeremy
Cobat, Aurélie
Orlova, Marianna
Van Thuc, Nguyen
Moraes, Milton O.
Marques, Carolinne Sales
Stefani, Mariane M. A.
Latini, Ana Carla P.
Belone, Andrea F.
Thai, Vu Hong
Abel, Laurent
Alcaïs, Alexandre
Schurr, Erwin
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fava, Vinicius M.
Manry, Jeremy
Cobat, Aurélie
Orlova, Marianna
Van Thuc, Nguyen
Moraes, Milton O.
Marques, Carolinne Sales
Stefani, Mariane M. A.
Latini, Ana Carla P.
Belone, Andrea F.
Thai, Vu Hong
Abel, Laurent
Alcaïs, Alexandre
Schurr, Erwin
dc.subject.other.pt_BR.fl_str_mv Hanseníase
Fator de risco
RNA Longo não Codificante
inflamatório patológico
topic Hanseníase
Fator de risco
RNA Longo não Codificante
inflamatório patológico
Leprosy
lncRna
Risk factor
pathological inflammatory
dc.subject.en.pt_BR.fl_str_mv Leprosy
lncRna
Risk factor
pathological inflammatory
description Research Institute of the McGill University Health Centre. Program in Infectious Diseases and Immunity in Global Health. Montreal, Quebec, canada / McGill University. The McGill International TB Centre, Departments of Human Genetics and Medicine. Montreal, Quebec, Canada.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-02-08T11:28:23Z
dc.date.available.fl_str_mv 2018-02-08T11:28:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FAVA, Vinicius M. et al. A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy. PLoS Genet., v.13, n.2, e1006637, 16p, Feb. 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/24757
dc.identifier.issn.pt_BR.fl_str_mv 1553-7390
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pgen.1006637
dc.identifier.eissn.none.fl_str_mv 1553-7404
identifier_str_mv FAVA, Vinicius M. et al. A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy. PLoS Genet., v.13, n.2, e1006637, 16p, Feb. 2017.
1553-7390
10.1371/journal.pgen.1006637
1553-7404
url https://www.arca.fiocruz.br/handle/icict/24757
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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