LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Tipo de documento: | Trabalho de conclusão de curso |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/35780 |
Resumo: | Background: Many studies have demonstrated the association of atrial fibrillation (AF) with endogenous genetic regulatory mechanisms, as non-coding RNAs that could explain how the pathophysiological process occurs and suggest a possible early detection for some diseases, contributed also to the control of progression, among which are long non-coding RNAs (lncRNA). The objective of this review is to report the studies that analyzed the expression of lncRNAs in AF and the main experimental results reported and discuss the importance of these findings. Methods and results: For the selection of studies, a search was conducted on the PubMed public database (www.ncbi.nlm.nih.gov/pubmed) using the terms “lncRNA and atrial fibrillation” or “long ncRNA and atrial fibrillation” or “non-coding long RNA and atrial fibrillation”. Twenty studies were identified in this research. Of these, one is a review article, four articles in which lncRNAs were not related and fifteen represent original research. Of the 15 studies that continued in our review 10 were in tissue samples, 3 were in blood samples and 2 in vitro cell samples. No lncRNA was repeated, we attributed these variations to the sample type, method, species, and patient classification approached in the studies. Conclusion: The role of lncRNAs and the pathophysiology of atrial fibrillation is not yet well understood, so there is a need to encourage studies to elucidate this role. |
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Viana, Thamila Arianny CarlosAnanília Medeiros Gomes da SilvaLuchessi, André DucatiSousa, Júlio César Vieira deSilbiger, Vivian Nogueira2019-11-22T18:02:36Z2021-09-20T17:51:21Z2019-11-22T18:02:36Z2021-09-20T17:51:21Z2019-11-062014094826VIANA, Thamila Arianny Carlos. LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology. 2019. 29f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2019.https://repositorio.ufrn.br/handle/123456789/35780Universidade Federal do Rio Grande do NorteUFRNBrasilFarmáciaAtrial fibrilationlncRNAbiomarkersregulatory mechanismsLncRNA and atrial fibrillation: new perspectives for molecular pathophysiologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisBackground: Many studies have demonstrated the association of atrial fibrillation (AF) with endogenous genetic regulatory mechanisms, as non-coding RNAs that could explain how the pathophysiological process occurs and suggest a possible early detection for some diseases, contributed also to the control of progression, among which are long non-coding RNAs (lncRNA). The objective of this review is to report the studies that analyzed the expression of lncRNAs in AF and the main experimental results reported and discuss the importance of these findings. Methods and results: For the selection of studies, a search was conducted on the PubMed public database (www.ncbi.nlm.nih.gov/pubmed) using the terms “lncRNA and atrial fibrillation” or “long ncRNA and atrial fibrillation” or “non-coding long RNA and atrial fibrillation”. Twenty studies were identified in this research. Of these, one is a review article, four articles in which lncRNAs were not related and fifteen represent original research. Of the 15 studies that continued in our review 10 were in tissue samples, 3 were in blood samples and 2 in vitro cell samples. No lncRNA was repeated, we attributed these variations to the sample type, method, species, and patient classification approached in the studies. Conclusion: The role of lncRNAs and the pathophysiology of atrial fibrillation is not yet well understood, so there is a need to encourage studies to elucidate this role.engreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccessORIGINALLNCRNAANDATRIALFIBRILLATION_VIANA_2019.pdfapplication/pdf389064https://repositorio.ufrn.br/bitstream/123456789/35780/1/LNCRNAANDATRIALFIBRILLATION_VIANA_2019.pdf07fdd26834796466a06522a5a9cfd727MD51LICENSElicense.txttext/plain762https://repositorio.ufrn.br/bitstream/123456789/35780/2/license.txte428689918449bd69f843393981e4109MD52TEXTLNCRNAANDATRIALFIBRILLATION_VIANA_2019.pdf.txtExtracted texttext/plain33971https://repositorio.ufrn.br/bitstream/123456789/35780/3/LNCRNAANDATRIALFIBRILLATION_VIANA_2019.pdf.txtbda64b749a438d8ffdf40e3402b9bb84MD53123456789/357802021-09-20 14:51:21.207oai:https://repositorio.ufrn.br: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ório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-09-20T17:51:21Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology |
title |
LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology |
spellingShingle |
LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology Viana, Thamila Arianny Carlos Atrial fibrilation lncRNA biomarkers regulatory mechanisms |
title_short |
LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology |
title_full |
LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology |
title_fullStr |
LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology |
title_full_unstemmed |
LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology |
title_sort |
LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology |
author |
Viana, Thamila Arianny Carlos |
author_facet |
Viana, Thamila Arianny Carlos |
author_role |
author |
dc.contributor.referees1.none.fl_str_mv |
Luchessi, André Ducati |
dc.contributor.referees2.none.fl_str_mv |
Sousa, Júlio César Vieira de |
dc.contributor.author.fl_str_mv |
Viana, Thamila Arianny Carlos |
dc.contributor.advisor-co1.fl_str_mv |
Ananília Medeiros Gomes da Silva |
dc.contributor.advisor1.fl_str_mv |
Silbiger, Vivian Nogueira |
contributor_str_mv |
Ananília Medeiros Gomes da Silva Silbiger, Vivian Nogueira |
dc.subject.por.fl_str_mv |
Atrial fibrilation lncRNA biomarkers regulatory mechanisms |
topic |
Atrial fibrilation lncRNA biomarkers regulatory mechanisms |
description |
Background: Many studies have demonstrated the association of atrial fibrillation (AF) with endogenous genetic regulatory mechanisms, as non-coding RNAs that could explain how the pathophysiological process occurs and suggest a possible early detection for some diseases, contributed also to the control of progression, among which are long non-coding RNAs (lncRNA). The objective of this review is to report the studies that analyzed the expression of lncRNAs in AF and the main experimental results reported and discuss the importance of these findings. Methods and results: For the selection of studies, a search was conducted on the PubMed public database (www.ncbi.nlm.nih.gov/pubmed) using the terms “lncRNA and atrial fibrillation” or “long ncRNA and atrial fibrillation” or “non-coding long RNA and atrial fibrillation”. Twenty studies were identified in this research. Of these, one is a review article, four articles in which lncRNAs were not related and fifteen represent original research. Of the 15 studies that continued in our review 10 were in tissue samples, 3 were in blood samples and 2 in vitro cell samples. No lncRNA was repeated, we attributed these variations to the sample type, method, species, and patient classification approached in the studies. Conclusion: The role of lncRNAs and the pathophysiology of atrial fibrillation is not yet well understood, so there is a need to encourage studies to elucidate this role. |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-11-22T18:02:36Z 2021-09-20T17:51:21Z |
dc.date.available.fl_str_mv |
2019-11-22T18:02:36Z 2021-09-20T17:51:21Z |
dc.date.issued.fl_str_mv |
2019-11-06 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
format |
bachelorThesis |
status_str |
publishedVersion |
dc.identifier.pt_BR.fl_str_mv |
2014094826 |
dc.identifier.citation.fl_str_mv |
VIANA, Thamila Arianny Carlos. LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology. 2019. 29f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2019. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/35780 |
identifier_str_mv |
2014094826 VIANA, Thamila Arianny Carlos. LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology. 2019. 29f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2019. |
url |
https://repositorio.ufrn.br/handle/123456789/35780 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal do Rio Grande do Norte |
dc.publisher.initials.fl_str_mv |
UFRN |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Farmácia |
publisher.none.fl_str_mv |
Universidade Federal do Rio Grande do Norte |
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