LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology

Detalhes bibliográficos
Autor(a) principal: Viana, Thamila Arianny Carlos
Data de Publicação: 2019
Tipo de documento: Trabalho de conclusão de curso
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/handle/123456789/35780
Resumo: Background: Many studies have demonstrated the association of atrial fibrillation (AF) with endogenous genetic regulatory mechanisms, as non-coding RNAs that could explain how the pathophysiological process occurs and suggest a possible early detection for some diseases, contributed also to the control of progression, among which are long non-coding RNAs (lncRNA). The objective of this review is to report the studies that analyzed the expression of lncRNAs in AF and the main experimental results reported and discuss the importance of these findings. Methods and results: For the selection of studies, a search was conducted on the PubMed public database (www.ncbi.nlm.nih.gov/pubmed) using the terms “lncRNA and atrial fibrillation” or “long ncRNA and atrial fibrillation” or “non-coding long RNA and atrial fibrillation”. Twenty studies were identified in this research. Of these, one is a review article, four articles in which lncRNAs were not related and fifteen represent original research. Of the 15 studies that continued in our review 10 were in tissue samples, 3 were in blood samples and 2 in vitro cell samples. No lncRNA was repeated, we attributed these variations to the sample type, method, species, and patient classification approached in the studies. Conclusion: The role of lncRNAs and the pathophysiology of atrial fibrillation is not yet well understood, so there is a need to encourage studies to elucidate this role.
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spelling Viana, Thamila Arianny CarlosAnanília Medeiros Gomes da SilvaLuchessi, André DucatiSousa, Júlio César Vieira deSilbiger, Vivian Nogueira2019-11-22T18:02:36Z2021-09-20T17:51:21Z2019-11-22T18:02:36Z2021-09-20T17:51:21Z2019-11-062014094826VIANA, Thamila Arianny Carlos. LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology. 2019. 29f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2019.https://repositorio.ufrn.br/handle/123456789/35780Universidade Federal do Rio Grande do NorteUFRNBrasilFarmáciaAtrial fibrilationlncRNAbiomarkersregulatory mechanismsLncRNA and atrial fibrillation: new perspectives for molecular pathophysiologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisBackground: Many studies have demonstrated the association of atrial fibrillation (AF) with endogenous genetic regulatory mechanisms, as non-coding RNAs that could explain how the pathophysiological process occurs and suggest a possible early detection for some diseases, contributed also to the control of progression, among which are long non-coding RNAs (lncRNA). The objective of this review is to report the studies that analyzed the expression of lncRNAs in AF and the main experimental results reported and discuss the importance of these findings. Methods and results: For the selection of studies, a search was conducted on the PubMed public database (www.ncbi.nlm.nih.gov/pubmed) using the terms “lncRNA and atrial fibrillation” or “long ncRNA and atrial fibrillation” or “non-coding long RNA and atrial fibrillation”. Twenty studies were identified in this research. Of these, one is a review article, four articles in which lncRNAs were not related and fifteen represent original research. Of the 15 studies that continued in our review 10 were in tissue samples, 3 were in blood samples and 2 in vitro cell samples. No lncRNA was repeated, we attributed these variations to the sample type, method, species, and patient classification approached in the studies. Conclusion: The role of lncRNAs and the pathophysiology of atrial fibrillation is not yet well understood, so there is a need to encourage studies to elucidate this role.engreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccessORIGINALLNCRNAANDATRIALFIBRILLATION_VIANA_2019.pdfapplication/pdf389064https://repositorio.ufrn.br/bitstream/123456789/35780/1/LNCRNAANDATRIALFIBRILLATION_VIANA_2019.pdf07fdd26834796466a06522a5a9cfd727MD51LICENSElicense.txttext/plain762https://repositorio.ufrn.br/bitstream/123456789/35780/2/license.txte428689918449bd69f843393981e4109MD52TEXTLNCRNAANDATRIALFIBRILLATION_VIANA_2019.pdf.txtExtracted texttext/plain33971https://repositorio.ufrn.br/bitstream/123456789/35780/3/LNCRNAANDATRIALFIBRILLATION_VIANA_2019.pdf.txtbda64b749a438d8ffdf40e3402b9bb84MD53123456789/357802021-09-20 14:51:21.207oai:https://repositorio.ufrn.br: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ório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-09-20T17:51:21Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology
title LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology
spellingShingle LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology
Viana, Thamila Arianny Carlos
Atrial fibrilation
lncRNA
biomarkers
regulatory mechanisms
title_short LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology
title_full LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology
title_fullStr LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology
title_full_unstemmed LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology
title_sort LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology
author Viana, Thamila Arianny Carlos
author_facet Viana, Thamila Arianny Carlos
author_role author
dc.contributor.referees1.none.fl_str_mv Luchessi, André Ducati
dc.contributor.referees2.none.fl_str_mv Sousa, Júlio César Vieira de
dc.contributor.author.fl_str_mv Viana, Thamila Arianny Carlos
dc.contributor.advisor-co1.fl_str_mv Ananília Medeiros Gomes da Silva
dc.contributor.advisor1.fl_str_mv Silbiger, Vivian Nogueira
contributor_str_mv Ananília Medeiros Gomes da Silva
Silbiger, Vivian Nogueira
dc.subject.por.fl_str_mv Atrial fibrilation
lncRNA
biomarkers
regulatory mechanisms
topic Atrial fibrilation
lncRNA
biomarkers
regulatory mechanisms
description Background: Many studies have demonstrated the association of atrial fibrillation (AF) with endogenous genetic regulatory mechanisms, as non-coding RNAs that could explain how the pathophysiological process occurs and suggest a possible early detection for some diseases, contributed also to the control of progression, among which are long non-coding RNAs (lncRNA). The objective of this review is to report the studies that analyzed the expression of lncRNAs in AF and the main experimental results reported and discuss the importance of these findings. Methods and results: For the selection of studies, a search was conducted on the PubMed public database (www.ncbi.nlm.nih.gov/pubmed) using the terms “lncRNA and atrial fibrillation” or “long ncRNA and atrial fibrillation” or “non-coding long RNA and atrial fibrillation”. Twenty studies were identified in this research. Of these, one is a review article, four articles in which lncRNAs were not related and fifteen represent original research. Of the 15 studies that continued in our review 10 were in tissue samples, 3 were in blood samples and 2 in vitro cell samples. No lncRNA was repeated, we attributed these variations to the sample type, method, species, and patient classification approached in the studies. Conclusion: The role of lncRNAs and the pathophysiology of atrial fibrillation is not yet well understood, so there is a need to encourage studies to elucidate this role.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-11-22T18:02:36Z
2021-09-20T17:51:21Z
dc.date.available.fl_str_mv 2019-11-22T18:02:36Z
2021-09-20T17:51:21Z
dc.date.issued.fl_str_mv 2019-11-06
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/bachelorThesis
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dc.identifier.pt_BR.fl_str_mv 2014094826
dc.identifier.citation.fl_str_mv VIANA, Thamila Arianny Carlos. LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology. 2019. 29f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2019.
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/handle/123456789/35780
identifier_str_mv 2014094826
VIANA, Thamila Arianny Carlos. LncRNA and atrial fibrillation: new perspectives for molecular pathophysiology. 2019. 29f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2019.
url https://repositorio.ufrn.br/handle/123456789/35780
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal do Rio Grande do Norte
dc.publisher.initials.fl_str_mv UFRN
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Farmácia
publisher.none.fl_str_mv Universidade Federal do Rio Grande do Norte
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRN
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