Oleic acid induces lung injury in mice through activation of the ERK pathway
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/23016 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil. |
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Albuquerque, Cassiano Felippe Gonçalves deSilva, Adriana RibeiroBurth, PatríciaMoraes, Isabel Matos Medeiros deOliveira, Flora Magno de JesusYounes-Ibrahim, MauricioSantos, Maria da Conceição Batista dosD'Avila, HeloisaBozza, Patrícia TorresFaria Neto, Hugo Caire de CastroFaria, Mauro Velho de Castro2017-11-01T11:57:07Z2017-11-01T11:57:07Z2012ALBUQUERQUE, Cassiano Felipe Gonçalves de; et al. .Oleic Acid Induces Lung Injury inMice through Activation of the ERK Pathway. Mediators of Inflammation, Volume 2012, Article ID956509, 11p, 2012.0962-9351https://www.arca.fiocruz.br/handle/icict/2301610.1155/2012/9565091466-1861engHindawi Publishing CorporationÁcido OleicoLesão PulmonarSíndrome do Desconforto Respiratório do AdultoSistema de Sinalização das MAP QuinasesOleic AcidLung InjuryAdult respiratory distress syndromeERK PathwayOleic acid induces lung injury in mice through activation of the ERK pathwayinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Medicina Interna. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Medicina Interna. Rio de Janeiro, RJ, Brasil.Universidade de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Biologia Celular. Juiz de Fora, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Medicina Interna. Rio de Janeiro, RJ, Brasil.Oleic acid (OA) can induce acute lung injury in experimental models. In the present work, we used intratracheal OA injection to show augmented oedema formation, cell migration and activation, lipid mediator, and cytokine productions in the bronchoalveolar fluids of Swiss Webster mice. We also demonstrated that OA-induced pulmonary injury is dependent on ERK1/2 activation, since U0126, an inhibitor of ERK1/2 phosphorylation, blocked neutrophil migration, oedema, and lipid body formation as well as IL-6, but not IL-1β production. Using a mice strain carrying a null mutation for the TLR4 receptor, we proved that increased inflammatory parameters after OA challenges were not due to the activation of the TLR4 receptor. With OA being a Na/K-ATPase inhibitor, we suggest the possible involvement of this enzyme as an OA target triggering lung inflammation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/23016/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALcassiano_albuquerque_etal_IOC_2012.pdfcassiano_albuquerque_etal_IOC_2012.pdfapplication/pdf2701606https://www.arca.fiocruz.br/bitstream/icict/23016/2/cassiano_albuquerque_etal_IOC_2012.pdff23f9ac79992094699d7106e9c286452MD52TEXTcassiano_albuquerque_etal_IOC_2012.pdf.txtcassiano_albuquerque_etal_IOC_2012.pdf.txtExtracted texttext/plain46084https://www.arca.fiocruz.br/bitstream/icict/23016/3/cassiano_albuquerque_etal_IOC_2012.pdf.txtc2ab631d1f57f3ec1114cf3610cb552eMD53icict/230162023-09-05 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| dc.title.pt_BR.fl_str_mv |
Oleic acid induces lung injury in mice through activation of the ERK pathway |
| title |
Oleic acid induces lung injury in mice through activation of the ERK pathway |
| spellingShingle |
Oleic acid induces lung injury in mice through activation of the ERK pathway Albuquerque, Cassiano Felippe Gonçalves de Ácido Oleico Lesão Pulmonar Síndrome do Desconforto Respiratório do Adulto Sistema de Sinalização das MAP Quinases Oleic Acid Lung Injury Adult respiratory distress syndrome ERK Pathway |
| title_short |
Oleic acid induces lung injury in mice through activation of the ERK pathway |
| title_full |
Oleic acid induces lung injury in mice through activation of the ERK pathway |
| title_fullStr |
Oleic acid induces lung injury in mice through activation of the ERK pathway |
| title_full_unstemmed |
Oleic acid induces lung injury in mice through activation of the ERK pathway |
| title_sort |
Oleic acid induces lung injury in mice through activation of the ERK pathway |
| author |
Albuquerque, Cassiano Felippe Gonçalves de |
| author_facet |
Albuquerque, Cassiano Felippe Gonçalves de Silva, Adriana Ribeiro Burth, Patrícia Moraes, Isabel Matos Medeiros de Oliveira, Flora Magno de Jesus Younes-Ibrahim, Mauricio Santos, Maria da Conceição Batista dos D'Avila, Heloisa Bozza, Patrícia Torres Faria Neto, Hugo Caire de Castro Faria, Mauro Velho de Castro |
| author_role |
author |
| author2 |
Silva, Adriana Ribeiro Burth, Patrícia Moraes, Isabel Matos Medeiros de Oliveira, Flora Magno de Jesus Younes-Ibrahim, Mauricio Santos, Maria da Conceição Batista dos D'Avila, Heloisa Bozza, Patrícia Torres Faria Neto, Hugo Caire de Castro Faria, Mauro Velho de Castro |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Albuquerque, Cassiano Felippe Gonçalves de Silva, Adriana Ribeiro Burth, Patrícia Moraes, Isabel Matos Medeiros de Oliveira, Flora Magno de Jesus Younes-Ibrahim, Mauricio Santos, Maria da Conceição Batista dos D'Avila, Heloisa Bozza, Patrícia Torres Faria Neto, Hugo Caire de Castro Faria, Mauro Velho de Castro |
| dc.subject.other.pt_BR.fl_str_mv |
Ácido Oleico Lesão Pulmonar Síndrome do Desconforto Respiratório do Adulto Sistema de Sinalização das MAP Quinases |
| topic |
Ácido Oleico Lesão Pulmonar Síndrome do Desconforto Respiratório do Adulto Sistema de Sinalização das MAP Quinases Oleic Acid Lung Injury Adult respiratory distress syndrome ERK Pathway |
| dc.subject.en.pt_BR.fl_str_mv |
Oleic Acid Lung Injury Adult respiratory distress syndrome ERK Pathway |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil. |
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2012 |
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2012 |
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2017-11-01T11:57:07Z |
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2017-11-01T11:57:07Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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ALBUQUERQUE, Cassiano Felipe Gonçalves de; et al. .Oleic Acid Induces Lung Injury inMice through Activation of the ERK Pathway. Mediators of Inflammation, Volume 2012, Article ID956509, 11p, 2012. |
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https://www.arca.fiocruz.br/handle/icict/23016 |
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0962-9351 |
| dc.identifier.doi.none.fl_str_mv |
10.1155/2012/956509 |
| dc.identifier.eissn.none.fl_str_mv |
1466-1861 |
| identifier_str_mv |
ALBUQUERQUE, Cassiano Felipe Gonçalves de; et al. .Oleic Acid Induces Lung Injury inMice through Activation of the ERK Pathway. Mediators of Inflammation, Volume 2012, Article ID956509, 11p, 2012. 0962-9351 10.1155/2012/956509 1466-1861 |
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Hindawi Publishing Corporation |
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Hindawi Publishing Corporation |
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