Influence of treatment with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi.

Detalhes bibliográficos
Autor(a) principal: Andrade, Sonia Gumes
Data de Publicação: 1997
Outros Autores: Carneiro Filho, Aydano, Souza, André J. Maia de, Lima, Elianita Suzart de, Andrade, Zilton de Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5674
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Andrade, Sonia GumesCarneiro Filho, AydanoSouza, André J. Maia deLima, Elianita Suzart deAndrade, Zilton de Araújo2012-10-16T19:16:09Z2012-10-16T19:16:09Z1997ANDRADE, S. G. et al. Influence of treatment with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi. International Journal of Experiemental Pathology, v. 78, n. 6, p. 391-9, dec. 1997.0959-9673https://www.arca.fiocruz.br/handle/icict/5674engInfluence of treatment with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilLatent Trypanosoma cruzi infection may be reactivated in immunosuppressed individuals, with unusual clinical patterns, such as meningoencephalitis, pseudo neoplastic lesions in the central nervous system, and myocarditis with numerous parasites in the heart muscle. To investigate this problem 68 Swiss mice chronically infected with different strains of T. cruzi were treated with different combinations of immunosuppressive drugs (azathioprine, cyclosporine and betamethasone), in such a way as to imitate the situation during post transplantation treatment. Mortality varied from 6 to 25% in treated mice. There were no deaths in untreated controls. Normal mice have been submitted to the same schedules of immunosuppression as controls of treatment and no deaths were registered during treatment. Chronically infected mice showed significant elevation of total number of leukocytes and lymphocytes in comparison with intact controls; a significant decrease in blood leukocytes and lymphocytes occurred post-treatment in two of the treated experimental groups. Exacerbation of myocarditis and myositis and a high incidence of brain lesions, with focal necrosis, granulomatous lesions and glial proliferation even in the absence of parasites were present in immunosuppressed mice but not in infected controls. Although differing in some aspects from Chagas' disease in immunosuppressed humans, the murine model did show some features that resembled it, especially the peculiar pattern of central nervous system involvement.Trypanosoma cruziImmunosuppressionAzathioprineCyclosporineBetamethasoneDoença de Chagas/imunologiaModelos Animais de DoençasImunossupressores/efeitos adversosAnimaisAnticorpos Anti-Helmínticos/sangueAzatioprina/efeitos adversosBetametasona/efeitos adversosEncéfalo/parasitologiaDoença CrônicaCiclosporina/efeitos adversosContagem de LeucócitosContagem de LinfócitosCamundongosCamundongos EndogâmicosRecidivaTransplanteinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAndrade SG Influence of treatment....pdfAndrade SG Influence of treatment....pdfapplication/pdf698718https://www.arca.fiocruz.br/bitstream/icict/5674/1/Andrade%20SG%20Influence%20of%20treatment....pdfec09bc62725c38168d0a3f257d037f91MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5674/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTAndrade SG Influence of treatment....pdf.txtAndrade SG Influence of treatment....pdf.txtExtracted texttext/plain30239https://www.arca.fiocruz.br/bitstream/icict/5674/5/Andrade%20SG%20Influence%20of%20treatment....pdf.txt425f84de6900a7f609f07eef78681793MD55THUMBNAILAndrade SG Influence of treatment....pdf.jpgAndrade SG Influence of treatment....pdf.jpgGenerated Thumbnailimage/jpeg1871https://www.arca.fiocruz.br/bitstream/icict/5674/4/Andrade%20SG%20Influence%20of%20treatment....pdf.jpgd5130ead2065309d2782f05806882f3eMD54icict/56742023-03-15 14:33:13.724oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:13Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Influence of treatment with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi.
title Influence of treatment with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi.
spellingShingle Influence of treatment with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi.
Andrade, Sonia Gumes
Trypanosoma cruzi
Immunosuppression
Azathioprine
Cyclosporine
Betamethasone
Doença de Chagas/imunologia
Modelos Animais de Doenças
Imunossupressores/efeitos adversos
Animais
Anticorpos Anti-Helmínticos/sangue
Azatioprina/efeitos adversos
Betametasona/efeitos adversos
Encéfalo/parasitologia
Doença Crônica
Ciclosporina/efeitos adversos
Contagem de Leucócitos
Contagem de Linfócitos
Camundongos
Camundongos Endogâmicos
Recidiva
Transplante
title_short Influence of treatment with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi.
title_full Influence of treatment with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi.
title_fullStr Influence of treatment with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi.
title_full_unstemmed Influence of treatment with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi.
title_sort Influence of treatment with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi.
author Andrade, Sonia Gumes
author_facet Andrade, Sonia Gumes
Carneiro Filho, Aydano
Souza, André J. Maia de
Lima, Elianita Suzart de
Andrade, Zilton de Araújo
author_role author
author2 Carneiro Filho, Aydano
Souza, André J. Maia de
Lima, Elianita Suzart de
Andrade, Zilton de Araújo
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Sonia Gumes
Carneiro Filho, Aydano
Souza, André J. Maia de
Lima, Elianita Suzart de
Andrade, Zilton de Araújo
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
Immunosuppression
Azathioprine
Cyclosporine
Betamethasone
topic Trypanosoma cruzi
Immunosuppression
Azathioprine
Cyclosporine
Betamethasone
Doença de Chagas/imunologia
Modelos Animais de Doenças
Imunossupressores/efeitos adversos
Animais
Anticorpos Anti-Helmínticos/sangue
Azatioprina/efeitos adversos
Betametasona/efeitos adversos
Encéfalo/parasitologia
Doença Crônica
Ciclosporina/efeitos adversos
Contagem de Leucócitos
Contagem de Linfócitos
Camundongos
Camundongos Endogâmicos
Recidiva
Transplante
dc.subject.decs.pt_BR.fl_str_mv Doença de Chagas/imunologia
Modelos Animais de Doenças
Imunossupressores/efeitos adversos
Animais
Anticorpos Anti-Helmínticos/sangue
Azatioprina/efeitos adversos
Betametasona/efeitos adversos
Encéfalo/parasitologia
Doença Crônica
Ciclosporina/efeitos adversos
Contagem de Leucócitos
Contagem de Linfócitos
Camundongos
Camundongos Endogâmicos
Recidiva
Transplante
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 1997
dc.date.issued.fl_str_mv 1997
dc.date.accessioned.fl_str_mv 2012-10-16T19:16:09Z
dc.date.available.fl_str_mv 2012-10-16T19:16:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, S. G. et al. Influence of treatment with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi. International Journal of Experiemental Pathology, v. 78, n. 6, p. 391-9, dec. 1997.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5674
dc.identifier.issn.none.fl_str_mv 0959-9673
identifier_str_mv ANDRADE, S. G. et al. Influence of treatment with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi. International Journal of Experiemental Pathology, v. 78, n. 6, p. 391-9, dec. 1997.
0959-9673
url https://www.arca.fiocruz.br/handle/icict/5674
dc.language.iso.fl_str_mv eng
language eng
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instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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