Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias.

Andrade, Sonia Gumes; Mesquita, Igor Marcelo Oliveira; Jambeiro, Jamile F.; Santos, Isis Fernandes Magalhães; Portella, Renata Siqueira

Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias.

Detalhes bibliográficos
Autor(a) principal:	Andrade, Sonia Gumes
Data de Publicação:	2003
Outros Autores:	Mesquita, Igor Marcelo Oliveira, Jambeiro, Jamile F., Santos, Isis Fernandes Magalhães, Portella, Renata Siqueira
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/3881
Resumo:	Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.

Metadados do item

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spelling	Andrade, Sonia GumesMesquita, Igor Marcelo OliveiraJambeiro, Jamile F.Santos, Isis Fernandes MagalhãesPortella, Renata Siqueira2012-05-04T18:57:36Z2012-05-04T18:57:36Z2003ANDRADE, S.G. et al. Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias. Revista da Sociedade Brasileira de Medicina Tropical, v. 36, n. 4, p. 441-447, jul.-aug. 2003.0037-8682https://www.arca.fiocruz.br/handle/icict/3881engTrypanosoma cruziInfecção ExperimentalQuimioterapiaBenzonidazolDrogas ImunossupressorasLinfoma não HodgkinTrypanosoma cruziExperimental InfectionChemotherapyBenznidazoleImmunosuppressive DrugsNon-Hodgkin’s lymphomaDoença de Chagas/quimioterapiaImunossupressores/efeitos adversosNeoplasias/induzido quimicamenteNitroimidazóis/efeitos adversosTripanossomicidas/efeitos adversosDoença CrônicaTreatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Benznidazole is recommended in Brazil for the treatment of Trypanosoma cruzi infection in acute and early chronic phases of Chagas' disease. Observations by others have indicated a higher incidence of neoplasias in immunosuppressed patients, presenting Chagas' disease reactivation, submitted to treatment with benznidazole. In the present study, we investigated whether there is a potentiation in the generation of lymphomas in chronically infected mice, treated with immunosuppressive drugs and benznidazole. For this, 142 Swiss mice chronically infected with the 21 SF strain of T. cruzi and 72 normal Swiss mice were used. Both infected and normal mice were divided into experimental groups and submitted to one of the following treatment regimens: benznidazole alone; immunosuppressive drugs (azathioprine, betamethasone and cyclosporin); a combination of immunosuppressive drugs and benznidazole; and untreated controls. In the infected group treated with benznidazole, one mouse developed a non-Hodgkin's lymphoma. This finding has been interpreted as a spontaneous tumor of mice. The study of the chronically infected mice treated with the combination of immunosuppressive drugs and benznidazole demonstrated an absence of lymphomas or other neoplasias. These findings support the indication of benznidazole, as the drug of choice, for immunosuppressed patients that develop a reactivation of Chagas' disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAndrade SG Treatment with benznidazole....pdfAndrade SG Treatment with benznidazole....pdfapplication/pdf163640https://www.arca.fiocruz.br/bitstream/icict/3881/1/Andrade%20SG%20Treatment%20with%20benznidazole....pdf46e86e704451026977039fba7f27741bMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/3881/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTAndrade SG Treatment with benznidazole....pdf.txtAndrade SG Treatment with benznidazole....pdf.txtExtracted texttext/plain28500https://www.arca.fiocruz.br/bitstream/icict/3881/5/Andrade%20SG%20Treatment%20with%20benznidazole....pdf.txtc7f0a0b20aeebafba33fa734e062132aMD55THUMBNAILAndrade SG Treatment with benznidazole....pdf.jpgAndrade SG Treatment with benznidazole....pdf.jpgGenerated Thumbnailimage/jpeg2082https://www.arca.fiocruz.br/bitstream/icict/3881/4/Andrade%20SG%20Treatment%20with%20benznidazole....pdf.jpga587b844490b5ea1e5d798db9e1708b7MD54icict/38812023-03-15 14:32:58.321oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:58Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias.
title	Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias.
spellingShingle	Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias. Andrade, Sonia Gumes Trypanosoma cruzi Infecção Experimental Quimioterapia Benzonidazol Drogas Imunossupressoras Linfoma não Hodgkin Trypanosoma cruzi Experimental Infection Chemotherapy Benznidazole Immunosuppressive Drugs Non-Hodgkin’s lymphoma Doença de Chagas/quimioterapia Imunossupressores/efeitos adversos Neoplasias/induzido quimicamente Nitroimidazóis/efeitos adversos Tripanossomicidas/efeitos adversos Doença Crônica
title_short	Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias.
title_full	Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias.
title_fullStr	Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias.
title_full_unstemmed	Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias.
title_sort	Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias.
author	Andrade, Sonia Gumes
author_facet	Andrade, Sonia Gumes Mesquita, Igor Marcelo Oliveira Jambeiro, Jamile F. Santos, Isis Fernandes Magalhães Portella, Renata Siqueira
author_role	author
author2	Mesquita, Igor Marcelo Oliveira Jambeiro, Jamile F. Santos, Isis Fernandes Magalhães Portella, Renata Siqueira
author2_role	author author author author
dc.contributor.author.fl_str_mv	Andrade, Sonia Gumes Mesquita, Igor Marcelo Oliveira Jambeiro, Jamile F. Santos, Isis Fernandes Magalhães Portella, Renata Siqueira
dc.subject.other.pt_BR.fl_str_mv	Trypanosoma cruzi Infecção Experimental Quimioterapia Benzonidazol Drogas Imunossupressoras Linfoma não Hodgkin
topic	Trypanosoma cruzi Infecção Experimental Quimioterapia Benzonidazol Drogas Imunossupressoras Linfoma não Hodgkin Trypanosoma cruzi Experimental Infection Chemotherapy Benznidazole Immunosuppressive Drugs Non-Hodgkin’s lymphoma Doença de Chagas/quimioterapia Imunossupressores/efeitos adversos Neoplasias/induzido quimicamente Nitroimidazóis/efeitos adversos Tripanossomicidas/efeitos adversos Doença Crônica
dc.subject.en.pt_BR.fl_str_mv	Trypanosoma cruzi Experimental Infection Chemotherapy Benznidazole Immunosuppressive Drugs Non-Hodgkin’s lymphoma
dc.subject.decs.pt_BR.fl_str_mv	Doença de Chagas/quimioterapia Imunossupressores/efeitos adversos Neoplasias/induzido quimicamente Nitroimidazóis/efeitos adversos Tripanossomicidas/efeitos adversos Doença Crônica
description	Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
publishDate	2003
dc.date.issued.fl_str_mv	2003
dc.date.accessioned.fl_str_mv	2012-05-04T18:57:36Z
dc.date.available.fl_str_mv	2012-05-04T18:57:36Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv	ANDRADE, S.G. et al. Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias. Revista da Sociedade Brasileira de Medicina Tropical, v. 36, n. 4, p. 441-447, jul.-aug. 2003.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/3881
dc.identifier.issn.none.fl_str_mv	0037-8682
identifier_str_mv	ANDRADE, S.G. et al. Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias. Revista da Sociedade Brasileira de Medicina Tropical, v. 36, n. 4, p. 441-447, jul.-aug. 2003. 0037-8682
url	https://www.arca.fiocruz.br/handle/icict/3881
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
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dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
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collection	Repositório Institucional da FIOCRUZ (ARCA)
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Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias.

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