Brain schistosomiasis in mice experimentally infected with Schistosoma mansoni

Detalhes bibliográficos
Autor(a) principal: Lambertucci, José Roberto
Data de Publicação: 2014
Outros Autores: Fidelis, Thiago André, Pereira, Thiago Almeida, Coelho, Paulo Marcos Zech, Pereira, Neusa Araújo, Souza, Márcia Maria de, Brasileiro Filho, Geraldo, Pereira, Fausto Edmundo Lima, Antunes, Carlos Mauricio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9412
Resumo: Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte, MG, Brasil
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spelling Lambertucci, José RobertoFidelis, Thiago AndréPereira, Thiago AlmeidaCoelho, Paulo Marcos ZechPereira, Neusa AraújoSouza, Márcia Maria deBrasileiro Filho, GeraldoPereira, Fausto Edmundo LimaAntunes, Carlos Mauricio2015-02-02T18:30:15Z2015-02-02T18:30:15Z2014LAMBERTUCCI, José Roberto et al. Brain schistosomiasis in mice experimentally infected with Schistosoma mansoni. Rev. Soc. Bras. Med. Trop., Uberaba, v. 47, n. 2, 2014 .0037-8682https://www.arca.fiocruz.br/handle/icict/941210.1590/0037-8682-0083-2013engSociedade Brasileira de Medicina TropicalBrain schistosomiasis in mice experimentally infected with Schistosoma mansoniinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Anatomia Patológica. Belo Horizonte, MG/Duke University Medical Center. Durham, North Carolin, USAFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilDuke University Medical Center. Durham, North Carolin, USAUniversidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Anatomia Patológica. Belo Horizonte, MGUniversidade Federal do Espírito Santo. Núcleo de Doenças Infecciosas. Vitória, ES, BrasilSanta Casa de Misericórdia de Belo Horizonte. Belo Horizonte, MG, BrasilIntroduction: Human neuroschistosomiasis has been reported in the literature, but the possibility of modeling neuroschistosomiasis in mice is controversial. Methods: In two research laboratories in Brazil that maintain the Schistosoma mansoni life cycle in rodents, two mice developed signs of brain disease (hemiplegia and spinning), and both were autopsied. Results: S. mansoni eggs, both with and without granuloma formation, were observed in the brain and meninges of both mice by optical microscopy. Conclusions: This is the first description of eggs in the brains of symptomatic mice that were experimentally infected with S. mansoni. An investigation of experimental neuroschistosomiasis is now feasible.SchistosomiasisExperimental neuroschistosomiasisBrain schistosomiasisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9412/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINAL2014_027.pdf2014_027.pdfapplication/pdf3468305https://www.arca.fiocruz.br/bitstream/icict/9412/2/2014_027.pdf54f1a07146aa9d37402047f1cf0a7acdMD52TEXT2014_027.pdf.txt2014_027.pdf.txtExtracted texttext/plain10681https://www.arca.fiocruz.br/bitstream/icict/9412/3/2014_027.pdf.txtd92f588f5220981d58595edf2f705d55MD53icict/94122019-06-19 10:05:41.26oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:05:41Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Brain schistosomiasis in mice experimentally infected with Schistosoma mansoni
title Brain schistosomiasis in mice experimentally infected with Schistosoma mansoni
spellingShingle Brain schistosomiasis in mice experimentally infected with Schistosoma mansoni
Lambertucci, José Roberto
Schistosomiasis
Experimental neuroschistosomiasis
Brain schistosomiasis
title_short Brain schistosomiasis in mice experimentally infected with Schistosoma mansoni
title_full Brain schistosomiasis in mice experimentally infected with Schistosoma mansoni
title_fullStr Brain schistosomiasis in mice experimentally infected with Schistosoma mansoni
title_full_unstemmed Brain schistosomiasis in mice experimentally infected with Schistosoma mansoni
title_sort Brain schistosomiasis in mice experimentally infected with Schistosoma mansoni
author Lambertucci, José Roberto
author_facet Lambertucci, José Roberto
Fidelis, Thiago André
Pereira, Thiago Almeida
Coelho, Paulo Marcos Zech
Pereira, Neusa Araújo
Souza, Márcia Maria de
Brasileiro Filho, Geraldo
Pereira, Fausto Edmundo Lima
Antunes, Carlos Mauricio
author_role author
author2 Fidelis, Thiago André
Pereira, Thiago Almeida
Coelho, Paulo Marcos Zech
Pereira, Neusa Araújo
Souza, Márcia Maria de
Brasileiro Filho, Geraldo
Pereira, Fausto Edmundo Lima
Antunes, Carlos Mauricio
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lambertucci, José Roberto
Fidelis, Thiago André
Pereira, Thiago Almeida
Coelho, Paulo Marcos Zech
Pereira, Neusa Araújo
Souza, Márcia Maria de
Brasileiro Filho, Geraldo
Pereira, Fausto Edmundo Lima
Antunes, Carlos Mauricio
dc.subject.en.pt_BR.fl_str_mv Schistosomiasis
Experimental neuroschistosomiasis
Brain schistosomiasis
topic Schistosomiasis
Experimental neuroschistosomiasis
Brain schistosomiasis
description Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte, MG, Brasil
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-02-02T18:30:15Z
dc.date.available.fl_str_mv 2015-02-02T18:30:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LAMBERTUCCI, José Roberto et al. Brain schistosomiasis in mice experimentally infected with Schistosoma mansoni. Rev. Soc. Bras. Med. Trop., Uberaba, v. 47, n. 2, 2014 .
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9412
dc.identifier.issn.none.fl_str_mv 0037-8682
dc.identifier.doi.none.fl_str_mv 10.1590/0037-8682-0083-2013
identifier_str_mv LAMBERTUCCI, José Roberto et al. Brain schistosomiasis in mice experimentally infected with Schistosoma mansoni. Rev. Soc. Bras. Med. Trop., Uberaba, v. 47, n. 2, 2014 .
0037-8682
10.1590/0037-8682-0083-2013
url https://www.arca.fiocruz.br/handle/icict/9412
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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