Brain schistosomiasis in mice experimentally infected with Schistosoma mansoni

• Autor(a) principal: Lambertucci,José Roberto
• Data de Publicação: 2014
• Outros Autores: Fidelis,Thiago André, Pereira,Thiago Almeida, Coelho,Paulo Marcos Zech, Araujo,Neuza, Souza,Márcia Maria de, Brasileiro Filho,Geraldo, Pereira,Fausto Edmundo Lima, Antunes,Carlos Mauricio
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000200251
• topic: Schistosomiasis; Experimental neuroschistosomiasis; Brain schistosomiasis

Introduction Human neuroschistosomiasis has been reported in the literature, but the possibility of modeling neuroschistosomiasis in mice is controversial. Methods In two research laboratories in Brazil that maintain the Schistosoma mansoni life cycle in rodents, two mice developed signs of brain disease (hemiplegia and spinning), and both were autopsied. Results S. mansoni eggs, both with and without granuloma formation, were observed in the brain and meninges of both mice by optical microscopy. Conclusions This is the first description of eggs in the brains of symptomatic mice that were experimentally infected with S. mansoni. An investigation of experimental neuroschistosomiasis is now feasible.