Congenital Zika syndrome is associated with maternal protein malnutrition
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/42579 |
Resumo: | Acesso aberto em 06/08/2020 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954064/pdf/aaw6284.pdf |
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Barbeito-Andrés, J.Pezzuto, P.Higa, L. M.Dias, A. A.Vasconcelos, J. M.Santos, T. M. P.Ferreira, J. C. C. G.Ferreira, R. O.Dutra, F. F.Rossi, A. D.Barbosa, R. V.Amorim, C. K. N.Souza, M. P. C. deChimelli, L.Aguiar, R. S.Gonzalez, P. N.Lara, F. A.Castro, M. C.Molnár, Z.Lopes, R. T.Bozza, M. T.Vianez, J. L. S. G.Barbeito, C. G.Cuervo, P.Bellio, M.Tanuri, A.Garcez, P. P.2020-08-06T19:26:26Z2020-08-06T19:26:26Z2020BARBEITO-ANDRÉS, J. et al. Congenital Zika syndrome is associated with maternal protein malnutrition. Virology, v. 6, p. 1-13, Jan. 2020.0042-6822https://www.arca.fiocruz.br/handle/icict/4257910.1126/sciadv.aaw6284Acesso aberto em 06/08/2020 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954064/pdf/aaw6284.pdfUniversidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil / Institute for Studies in Neuroscience and Complex Systems (ENyS) CONICET. Buenos Aires, Argentina.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Belém, PA, Brasil.Universidade Federal do Rio de Janeiro. Laboratório de Instrumentação Nuclear. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Rio de Janeiro, RJ, Brasil.Centro Nacional de Biologia Estrutural e Bioimagem- CENABIO. Rio de Janeiro, RJ, Brasil.Instituto Evandro Chagas. Centro de Inovações Tecnológicas. Ananindeua, PA, Brasil.Instituto Evandro Chagas. Centro de Inovações Tecnológicas. Ananindeua, PA, Brasil.Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Rio de Janeiro, RJ, Brasil.Institute for Studies in Neuroscience and Complex Systems (ENyS) CONICET. Buenos Aires, Argentina.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Department of Global Health and Population. Harvard T. H. Chan School of Public Health. Boston. MA, USA.University of Oxford. Department of Physiology, Anatomy and Genetics. Oxford, UK.Universidade Federal do Rio de Janeiro. Laboratório de Instrumentação Nuclear. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil.Instituto Evandro Chagas. Centro de Inovações Tecnológicas. Ananindeua, PA, Brasil.National University of La Plata. Faculty of Veterinary Sciences. Buenos Aires, Argentina.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.Zika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental impairments known as congenital Zika syndrome (CZS). The prevalence of this syndrome varies across ZIKV endemic regions, suggesting that its occurrence could depend on cofactors. Here, we evaluate the relevance of protein malnutrition for the emergence of CZS. Epidemiological data from the ZIKV outbreak in the Americas suggest a relationship between undernutrition and cases of microcephaly. To experimentally examine this relationship, we use immunocompetent pregnant mice, which were subjected to protein malnutrition and infected with a Brazilian ZIKV strain. We found that the combination of protein restriction and ZIKV infection leads to severe alterations of placental structure and embryonic body growth, with offspring displaying a reduction in neurogenesis and postnatal brain size. RNA-seq analysis reveals gene expression deregulation required for brain development in infected low-protein progeny. These results suggest that maternal protein malnutrition increases susceptibility to CZS.engElsevierZika virusGravidezSíndrome congênitaDesnutrição protéicaZika virusCongenital Zika syndromeMaternal protein malnutritionCongenital Zika syndrome is associated with maternal protein malnutritioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42579/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALF_LAra_PCuervo_etal_IOC_2020.pdfF_LAra_PCuervo_etal_IOC_2020.pdfapplication/pdf2752524https://www.arca.fiocruz.br/bitstream/icict/42579/2/F_LAra_PCuervo_etal_IOC_2020.pdfd3475fcdd054b40c7393e40286a8c8c7MD52TEXTF_LAra_PCuervo_etal_IOC_2020.pdf.txtF_LAra_PCuervo_etal_IOC_2020.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Congenital Zika syndrome is associated with maternal protein malnutrition |
| title |
Congenital Zika syndrome is associated with maternal protein malnutrition |
| spellingShingle |
Congenital Zika syndrome is associated with maternal protein malnutrition Barbeito-Andrés, J. Zika virus Gravidez Síndrome congênita Desnutrição protéica Zika virus Congenital Zika syndrome Maternal protein malnutrition |
| title_short |
Congenital Zika syndrome is associated with maternal protein malnutrition |
| title_full |
Congenital Zika syndrome is associated with maternal protein malnutrition |
| title_fullStr |
Congenital Zika syndrome is associated with maternal protein malnutrition |
| title_full_unstemmed |
Congenital Zika syndrome is associated with maternal protein malnutrition |
| title_sort |
Congenital Zika syndrome is associated with maternal protein malnutrition |
| author |
Barbeito-Andrés, J. |
| author_facet |
Barbeito-Andrés, J. Pezzuto, P. Higa, L. M. Dias, A. A. Vasconcelos, J. M. Santos, T. M. P. Ferreira, J. C. C. G. Ferreira, R. O. Dutra, F. F. Rossi, A. D. Barbosa, R. V. Amorim, C. K. N. Souza, M. P. C. de Chimelli, L. Aguiar, R. S. Gonzalez, P. N. Lara, F. A. Castro, M. C. Molnár, Z. Lopes, R. T. Bozza, M. T. Vianez, J. L. S. G. Barbeito, C. G. Cuervo, P. Bellio, M. Tanuri, A. Garcez, P. P. |
| author_role |
author |
| author2 |
Pezzuto, P. Higa, L. M. Dias, A. A. Vasconcelos, J. M. Santos, T. M. P. Ferreira, J. C. C. G. Ferreira, R. O. Dutra, F. F. Rossi, A. D. Barbosa, R. V. Amorim, C. K. N. Souza, M. P. C. de Chimelli, L. Aguiar, R. S. Gonzalez, P. N. Lara, F. A. Castro, M. C. Molnár, Z. Lopes, R. T. Bozza, M. T. Vianez, J. L. S. G. Barbeito, C. G. Cuervo, P. Bellio, M. Tanuri, A. Garcez, P. P. |
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author author author author author author author author author author author author author author author author author author author author author author author author author author |
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Barbeito-Andrés, J. Pezzuto, P. Higa, L. M. Dias, A. A. Vasconcelos, J. M. Santos, T. M. P. Ferreira, J. C. C. G. Ferreira, R. O. Dutra, F. F. Rossi, A. D. Barbosa, R. V. Amorim, C. K. N. Souza, M. P. C. de Chimelli, L. Aguiar, R. S. Gonzalez, P. N. Lara, F. A. Castro, M. C. Molnár, Z. Lopes, R. T. Bozza, M. T. Vianez, J. L. S. G. Barbeito, C. G. Cuervo, P. Bellio, M. Tanuri, A. Garcez, P. P. |
| dc.subject.other.pt_BR.fl_str_mv |
Zika virus Gravidez Síndrome congênita Desnutrição protéica |
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Zika virus Gravidez Síndrome congênita Desnutrição protéica Zika virus Congenital Zika syndrome Maternal protein malnutrition |
| dc.subject.en.pt_BR.fl_str_mv |
Zika virus Congenital Zika syndrome Maternal protein malnutrition |
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Acesso aberto em 06/08/2020 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954064/pdf/aaw6284.pdf |
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2020 |
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2020-08-06T19:26:26Z |
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2020-08-06T19:26:26Z |
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2020 |
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BARBEITO-ANDRÉS, J. et al. Congenital Zika syndrome is associated with maternal protein malnutrition. Virology, v. 6, p. 1-13, Jan. 2020. |
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https://www.arca.fiocruz.br/handle/icict/42579 |
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0042-6822 |
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10.1126/sciadv.aaw6284 |
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BARBEITO-ANDRÉS, J. et al. Congenital Zika syndrome is associated with maternal protein malnutrition. Virology, v. 6, p. 1-13, Jan. 2020. 0042-6822 10.1126/sciadv.aaw6284 |
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