Antinociceptive properties of bergenin
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | dx.doi.org/10.1021/np200232s |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/8987 |
Resumo: | Universidade Federal da Bahia. Salvador, BA, Brasil |
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Oliveira, Cristiane Metzker deNonato, Fabiana ReginaLima, Flávia Oliveira deCouto, Ricardo DavidDavid, Juceni Pereira de LimaDavid, Jorge MauricioSoares, Milena Botelho PereiraVillarreal, Cristiane Flora2014-11-27T19:13:52Z2014-11-27T19:13:52Z2011OLIVEIRA, C. M. et al. Antinociceptive properties of bergenin. Journal of Natural Products, v. 74, n. 10, p. 2062-2068, 2011.1520-6025https://www.arca.fiocruz.br/handle/icict/8987dx.doi.org/10.1021/np200232sengAmerican Chemical SocietyAntinociceptive properties of bergenininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Estadual de Feira de Santana. Feira de Santana, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilBergenin (1) is a C-glucoside of 4-O-methylgallic acid with known antiarthritic activity attributed to modulation of cytokine production. The present study was undertaken to evaluate whether 1 has antinociceptive properties in models of inflammatory pain and to investigate its possible mechanisms of action. Pretreatment with 1 (12.5-100 mg/kg, ip) produced a dose-related inhibition of acetic acid-induced writhing in mice. Furthermore, treatment with 1 (50 and 100 mg/kg) inhibited both the early and late phases in a formalin test. In addition, 1 (50 and 100 mg/kg, ip) inhibited mechanical hyperalgesia, edema, and paw production of hyperalgesic cytokines (TNF-α and IL-1ß) induced by complete Freund's adjuvant. However, the local production of IL-10, an anti-inflammatory cytokine, was not altered by 1 (100 mg/kg, ip). Treatment with 1 produced a similar profile of antinociception in wild-type and IL-10-deficient mice. Mice treated with 1 did not show any motor performance alterations or apparent systemic toxicity. The results presented herein demonstrate that bergenin has consistent antinociceptive and anti-inflammatory properties, acting by the inhibition of IL-1ß and TNF-α production, and suggest its potential for the control of inflammatory pain.Analgésicos/farmacologiaAnti-Inflamatórios não Esteroides/farmacologiaBenzopiranos/farmacologiaDor/quimioterapiaAnalgésicos/químicaAnimaisAnti-Inflamatórios não Esteroides/químicaBenzopiranos/químicaRelação Dose-Resposta a DrogaEdema/induzido quimicamenteÁcido Gálico/análogos & derivadosInterleucina-10/antagonistas & inibidoresInterleucina-10/biossínteseMasculinoCamundongosDor/induzido quimicamenteMedição da DorFator de Necrose Tumoral alfa/antagonistas & inibidoresinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8987/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALOliveira C M Antinociceptive....pdfOliveira C M Antinociceptive....pdfapplication/pdf1420717https://www.arca.fiocruz.br/bitstream/icict/8987/2/Oliveira%20C%20M%20Antinociceptive....pdf4247706d26a36f804881821f95401fc6MD52TEXTOliveira C M Antinociceptive....pdf.txtOliveira C M Antinociceptive....pdf.txtExtracted texttext/plain37589https://www.arca.fiocruz.br/bitstream/icict/8987/3/Oliveira%20C%20M%20Antinociceptive....pdf.txt2a76845ccd872ec2d871723e054d4468MD53icict/89872023-03-15 14:32:56.879oai:www.arca.fiocruz.br:icict/8987TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGNvbmNvcmRhciBlIGFjZWl0YXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKToKCmEpIERlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zDrXRpY2EgZGUgY29weXJpZ2h0IGRhIGVkaXRvcmEgZG8gc2V1IGRvY3VtZW50by4KCmIpIERlY2xhcmEgcXVlIGNvbmhlY2UgZSBhY2VpdGEgYXMgRGlyZXRyaXplcyBwYXJhIG8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgRnVuZGHDp8OjbyBPc3dhbGRvIENydXogKEZJT0NSVVopLgoKYykgQ29uY2VkZSDDoCBGSU9DUlVaIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyCiAKZS9vdSBkaXN0cmlidWlyIG5vIFJlcG9zaXTDs3JpbyBkYSBGSU9DUlVaLCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgCgpwb3IgcXVhbHF1ZXIgb3V0cm8gbWVpby4KCmQpIERlY2xhcmEgcXVlIGF1dG9yaXphIGEgRklPQ1JVWiBhIGFycXVpdmFyIG1haXMgZGUgdW1hIGPDs3BpYSBkZXN0ZSBkb2N1bWVudG8gZSBjb252ZXJ0w6otbG8sIHNlbSBhbHRlcmFyIG8gc2V1IGNvbnRlw7pkbywgCgpwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgYXJxdWl2bywgbWVpbyBvdSBzdXBvcnRlLCBwYXJhIGVmZWl0b3MgZGUgc2VndXJhbsOnYSwgcHJlc2VydmHDp8OjbyAoYmFja3VwKSBlIGFjZXNzby4KCmUpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBhIHRlcmNlaXJvcyBvcyBkaXJlaXRvcyAKCmNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuCgpmKSBEZWNsYXJhIHF1ZSwgbm8gY2FzbyBkbyBkb2N1bWVudG8gc3VibWV0aWRvIGNvbnRlciBtYXRlcmlhbCBkbyBxdWFsIG7Do28gZGV0w6ltIG9zIGRpcmVpdG9zIGRlIGF1dG9yLCBvYnRldmUgYSBhdXRvcml6YcOnw6NvIAoKaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhIEZJT0NSVVogb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIAoKdXRpbGl6w6EtbG9zIGxlZ2FsbWVudGUuIERlY2xhcmEgdGFtYsOpbSBxdWUgZXNzZSBtYXRlcmlhbCBjdWpvcyBkaXJlaXRvcyBzw6NvIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlIGlkZW50aWZpY2FkbyBlIHJlY29uaGVjaWRvIAoKbm8gdGV4dG8gb3UgY29udGXDumRvIGRvIGRvY3VtZW50byBlbnRyZWd1ZS4KCmcpIFNFIE8gRE9DVU1FTlRPIEVOVFJFR1VFIMOJIEJBU0VBRE8gRU0gVFJBQkFMSE8gRklOQU5DSUFETyBPVSBBUE9JQURPIFBPUiBPVVRSQSBJTlNUSVRVScOHw4NPIFFVRSBOw4NPIEEgRklPQ1JVWiwgREVDTEFSQSBRVUUgQ1VNUFJJVSAKClFVQUlTUVVFUiBPQlJJR0HDh8OVRVMgRVhJR0lEQVMgUEVMTyBSRVNQRUNUSVZPIENPTlRSQVRPIE9VIEFDT1JETy4gQSBGSU9DUlVaIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBvKHMpIG5vbWUocykgZG8ocykgYXV0b3IoZXMpIGRvcyAKCmRpcmVpdG9zIGRvIGRvY3VtZW50byBlbnRyZWd1ZSBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIHBhcmEgYWzDqW0gZG8gcHJldmlzdG8gbmEgYWzDrW5lYSBjKS4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:56Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Antinociceptive properties of bergenin |
| title |
Antinociceptive properties of bergenin |
| spellingShingle |
Antinociceptive properties of bergenin Oliveira, Cristiane Metzker de Analgésicos/farmacologia Anti-Inflamatórios não Esteroides/farmacologia Benzopiranos/farmacologia Dor/quimioterapia Analgésicos/química Animais Anti-Inflamatórios não Esteroides/química Benzopiranos/química Relação Dose-Resposta a Droga Edema/induzido quimicamente Ácido Gálico/análogos & derivados Interleucina-10/antagonistas & inibidores Interleucina-10/biossíntese Masculino Camundongos Dor/induzido quimicamente Medição da Dor Fator de Necrose Tumoral alfa/antagonistas & inibidores |
| title_short |
Antinociceptive properties of bergenin |
| title_full |
Antinociceptive properties of bergenin |
| title_fullStr |
Antinociceptive properties of bergenin |
| title_full_unstemmed |
Antinociceptive properties of bergenin |
| title_sort |
Antinociceptive properties of bergenin |
| author |
Oliveira, Cristiane Metzker de |
| author_facet |
Oliveira, Cristiane Metzker de Nonato, Fabiana Regina Lima, Flávia Oliveira de Couto, Ricardo David David, Juceni Pereira de Lima David, Jorge Mauricio Soares, Milena Botelho Pereira Villarreal, Cristiane Flora |
| author_role |
author |
| author2 |
Nonato, Fabiana Regina Lima, Flávia Oliveira de Couto, Ricardo David David, Juceni Pereira de Lima David, Jorge Mauricio Soares, Milena Botelho Pereira Villarreal, Cristiane Flora |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, Cristiane Metzker de Nonato, Fabiana Regina Lima, Flávia Oliveira de Couto, Ricardo David David, Juceni Pereira de Lima David, Jorge Mauricio Soares, Milena Botelho Pereira Villarreal, Cristiane Flora |
| dc.subject.decs.pt_BR.fl_str_mv |
Analgésicos/farmacologia Anti-Inflamatórios não Esteroides/farmacologia Benzopiranos/farmacologia Dor/quimioterapia Analgésicos/química Animais Anti-Inflamatórios não Esteroides/química Benzopiranos/química Relação Dose-Resposta a Droga Edema/induzido quimicamente Ácido Gálico/análogos & derivados Interleucina-10/antagonistas & inibidores Interleucina-10/biossíntese Masculino Camundongos Dor/induzido quimicamente Medição da Dor Fator de Necrose Tumoral alfa/antagonistas & inibidores |
| topic |
Analgésicos/farmacologia Anti-Inflamatórios não Esteroides/farmacologia Benzopiranos/farmacologia Dor/quimioterapia Analgésicos/química Animais Anti-Inflamatórios não Esteroides/química Benzopiranos/química Relação Dose-Resposta a Droga Edema/induzido quimicamente Ácido Gálico/análogos & derivados Interleucina-10/antagonistas & inibidores Interleucina-10/biossíntese Masculino Camundongos Dor/induzido quimicamente Medição da Dor Fator de Necrose Tumoral alfa/antagonistas & inibidores |
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Universidade Federal da Bahia. Salvador, BA, Brasil |
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2011 |
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2011 |
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2014-11-27T19:13:52Z |
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2014-11-27T19:13:52Z |
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OLIVEIRA, C. M. et al. Antinociceptive properties of bergenin. Journal of Natural Products, v. 74, n. 10, p. 2062-2068, 2011. |
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https://www.arca.fiocruz.br/handle/icict/8987 |
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1520-6025 |
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dx.doi.org/10.1021/np200232s |
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OLIVEIRA, C. M. et al. Antinociceptive properties of bergenin. Journal of Natural Products, v. 74, n. 10, p. 2062-2068, 2011. 1520-6025 dx.doi.org/10.1021/np200232s |
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