Schistosomiasis and liver fibrosis

Detalhes bibliográficos
Autor(a) principal: Andrade, Zilton de Araújo
Data de Publicação: 2009
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/1878
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Andrade, Zilton de Araújo2011-04-06T15:32:40Z2011-04-06T15:32:40Z2009ANDRADE, Z. de A. Schistosomiasis and liver fibrosis. Parasite Immunology, v. 31, n. 11, p. 656-663, 2009.1365-3024https://www.arca.fiocruz.br/handle/icict/187810.1111/j.1365-3024.2009.01157.xengSchistosomiasis and liver fibrosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilSchistosoma mansoni infection invariably results in liver fibrosis of the host. This fibrosis may be represented by small focal areas of chronic inflammation and excess extracellular matrix deposited in periovular granulomas, distributed in variable numbers at the periphery of the portal vein system. This is the outcome of 90% of the infected population in endemic areas. Conversely, a minority of infected individuals develop extensive disease with numerous granulomas along the entire extension of the portal spaces. This latter situation is mainly dependent on special hemodynamic changes created by a heavy worm load, with the subsequent production of numerous eggs and represents a severe form of a peculiar chronic hepatopathy. Thus, host-parasite interactions in schistosomiasis help us to understand a number of important features of liver fibrosis: its initiation and regulation, the significance of accompanying vascular changes, the dynamics of fibrosis formation and regression with antiparasitic treatment; host genetic and immunological contributions, and the pathophysiology of portal hypertension.FibrogenesisFibrosis regressionPeriovular granulomaPortal vasculopathySchistosoma mansoniEsquistossomoseFígadoFibroseSchistosoma mansoniinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSchistosomiasis and liver fibrosis.pdfSchistosomiasis and liver fibrosis.pdfapplication/pdf438380https://www.arca.fiocruz.br/bitstream/icict/1878/1/Schistosomiasis%20and%20liver%20fibrosis.pdfce435588570007f540d1784bdba732a9MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/1878/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTSchistosomiasis and liver fibrosis.pdf.txtSchistosomiasis and liver fibrosis.pdf.txtExtracted texttext/plain37117https://www.arca.fiocruz.br/bitstream/icict/1878/5/Schistosomiasis%20and%20liver%20fibrosis.pdf.txt7e8a627b8a5c861fc910840c72fe40daMD55THUMBNAILSchistosomiasis and liver fibrosis.pdf.jpgSchistosomiasis and liver fibrosis.pdf.jpgGenerated Thumbnailimage/jpeg2148https://www.arca.fiocruz.br/bitstream/icict/1878/4/Schistosomiasis%20and%20liver%20fibrosis.pdf.jpga94d6b004044e2c98432fc7a51c38204MD54icict/18782023-03-15 14:32:58.983oai:www.arca.fiocruz.br:icict/1878Tk9OLUVYQ0xVU0lWRSBESVNUUklCVVRJT04gTElDRU5TRQoKQnkgc2lnbmluZyBhbmQgc3VibWl0dGluZyB0aGlzIGxpY2Vuc2UsIHlvdSAodGhlIGF1dGhvcihzKSBvciBjb3B5cmlnaHQKb3duZXIpIGdyYW50cyB0byBEU3BhY2UgVW5pdmVyc2l0eSAoRFNVKSB0aGUgbm9uLWV4Y2x1c2l2ZSByaWdodCB0byByZXByb2R1Y2UsCnRyYW5zbGF0ZSAoYXMgZGVmaW5lZCBiZWxvdyksIGFuZC9vciBkaXN0cmlidXRlIHlvdXIgc3VibWlzc2lvbiAoaW5jbHVkaW5nCnRoZSBhYnN0cmFjdCkgd29ybGR3aWRlIGluIHByaW50IGFuZCBlbGVjdHJvbmljIGZvcm1hdCBhbmQgaW4gYW55IG1lZGl1bSwKaW5jbHVkaW5nIGJ1dCBub3QgbGltaXRlZCB0byBhdWRpbyBvciB2aWRlby4KCllvdSBhZ3JlZSB0aGF0IERTVSBtYXksIHdpdGhvdXQgY2hhbmdpbmcgdGhlIGNvbnRlbnQsIHRyYW5zbGF0ZSB0aGUKc3VibWlzc2lvbiB0byBhbnkgbWVkaXVtIG9yIGZvcm1hdCBmb3IgdGhlIHB1cnBvc2Ugb2YgcHJlc2VydmF0aW9uLgoKWW91IGFsc28gYWdyZWUgdGhhdCBEU1UgbWF5IGtlZXAgbW9yZSB0aGFuIG9uZSBjb3B5IG9mIHRoaXMgc3VibWlzc2lvbiBmb3IKcHVycG9zZXMgb2Ygc2VjdXJpdHksIGJhY2stdXAgYW5kIHByZXNlcnZhdGlvbi4KCllvdSByZXByZXNlbnQgdGhhdCB0aGUgc3VibWlzc2lvbiBpcyB5b3VyIG9yaWdpbmFsIHdvcmssIGFuZCB0aGF0IHlvdSBoYXZlCnRoZSByaWdodCB0byBncmFudCB0aGUgcmlnaHRzIGNvbnRhaW5lZCBpbiB0aGlzIGxpY2Vuc2UuIFlvdSBhbHNvIHJlcHJlc2VudAp0aGF0IHlvdXIgc3VibWlzc2lvbiBkb2VzIG5vdCwgdG8gdGhlIGJlc3Qgb2YgeW91ciBrbm93bGVkZ2UsIGluZnJpbmdlIHVwb24KYW55b25lJ3MgY29weXJpZ2h0LgoKSWYgdGhlIHN1Ym1pc3Npb24gY29udGFpbnMgbWF0ZXJpYWwgZm9yIHdoaWNoIHlvdSBkbyBub3QgaG9sZCBjb3B5cmlnaHQsCnlvdSByZXByZXNlbnQgdGhhdCB5b3UgaGF2ZSBvYnRhaW5lZCB0aGUgdW5yZXN0cmljdGVkIHBlcm1pc3Npb24gb2YgdGhlCmNvcHlyaWdodCBvd25lciB0byBncmFudCBEU1UgdGhlIHJpZ2h0cyByZXF1aXJlZCBieSB0aGlzIGxpY2Vuc2UsIGFuZCB0aGF0CnN1Y2ggdGhpcmQtcGFydHkgb3duZWQgbWF0ZXJpYWwgaXMgY2xlYXJseSBpZGVudGlmaWVkIGFuZCBhY2tub3dsZWRnZWQKd2l0aGluIHRoZSB0ZXh0IG9yIGNvbnRlbnQgb2YgdGhlIHN1Ym1pc3Npb24uCgpJRiBUSEUgU1VCTUlTU0lPTiBJUyBCQVNFRCBVUE9OIFdPUksgVEhBVCBIQVMgQkVFTiBTUE9OU09SRUQgT1IgU1VQUE9SVEVECkJZIEFOIEFHRU5DWSBPUiBPUkdBTklaQVRJT04gT1RIRVIgVEhBTiBEU1UsIFlPVSBSRVBSRVNFTlQgVEhBVCBZT1UgSEFWRQpGVUxGSUxMRUQgQU5ZIFJJR0hUIE9GIFJFVklFVyBPUiBPVEhFUiBPQkxJR0FUSU9OUyBSRVFVSVJFRCBCWSBTVUNICkNPTlRSQUNUIE9SIEFHUkVFTUVOVC4KCkRTVSB3aWxsIGNsZWFybHkgaWRlbnRpZnkgeW91ciBuYW1lKHMpIGFzIHRoZSBhdXRob3Iocykgb3Igb3duZXIocykgb2YgdGhlCnN1Ym1pc3Npb24sIGFuZCB3aWxsIG5vdCBtYWtlIGFueSBhbHRlcmF0aW9uLCBvdGhlciB0aGFuIGFzIGFsbG93ZWQgYnkgdGhpcwpsaWNlbnNlLCB0byB5b3VyIHN1Ym1pc3Npb24uCg==Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:58Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Schistosomiasis and liver fibrosis
title Schistosomiasis and liver fibrosis
spellingShingle Schistosomiasis and liver fibrosis
Andrade, Zilton de Araújo
Fibrogenesis
Fibrosis regression
Periovular granuloma
Portal vasculopathy
Schistosoma mansoni
Esquistossomose
Fígado
Fibrose
Schistosoma mansoni
title_short Schistosomiasis and liver fibrosis
title_full Schistosomiasis and liver fibrosis
title_fullStr Schistosomiasis and liver fibrosis
title_full_unstemmed Schistosomiasis and liver fibrosis
title_sort Schistosomiasis and liver fibrosis
author Andrade, Zilton de Araújo
author_facet Andrade, Zilton de Araújo
author_role author
dc.contributor.author.fl_str_mv Andrade, Zilton de Araújo
dc.subject.en.pt_BR.fl_str_mv Fibrogenesis
Fibrosis regression
Periovular granuloma
Portal vasculopathy
Schistosoma mansoni
topic Fibrogenesis
Fibrosis regression
Periovular granuloma
Portal vasculopathy
Schistosoma mansoni
Esquistossomose
Fígado
Fibrose
Schistosoma mansoni
dc.subject.decs.pt_BR.fl_str_mv Esquistossomose
Fígado
Fibrose
Schistosoma mansoni
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2011-04-06T15:32:40Z
dc.date.available.fl_str_mv 2011-04-06T15:32:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv ANDRADE, Z. de A. Schistosomiasis and liver fibrosis. Parasite Immunology, v. 31, n. 11, p. 656-663, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/1878
dc.identifier.issn.none.fl_str_mv 1365-3024
dc.identifier.doi.none.fl_str_mv 10.1111/j.1365-3024.2009.01157.x
identifier_str_mv ANDRADE, Z. de A. Schistosomiasis and liver fibrosis. Parasite Immunology, v. 31, n. 11, p. 656-663, 2009.
1365-3024
10.1111/j.1365-3024.2009.01157.x
url https://www.arca.fiocruz.br/handle/icict/1878
dc.language.iso.fl_str_mv eng
language eng
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dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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