Characterization of the vascular changes in schistosomal portal (pipestem) fibrosis of mice

Detalhes bibliográficos
Autor(a) principal: Silva, Luciana Menezes da
Data de Publicação: 2006
Outros Autores: Santos, Ricardo Ribeiro dos, Soares, Milena Botelho Pereira, Andrade, Zilton de Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/2755
Resumo: Agradecimentos a Sheilla Andrade de Oliveira, Rejane M.C. Menezes, Antonio Carlos S. Santos e Ana Cristina Gonzalez pelo apoio técnico e Brendan Flannery pela revisão do manuscrito.
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spelling Silva, Luciana Menezes daSantos, Ricardo Ribeiro dosSoares, Milena Botelho PereiraAndrade, Zilton de Araújo2011-07-15T13:22:06Z2011-07-15T13:22:06Z2006SILVA, L. M. et al. Characterization of the vascular changes in schistosomal portal (pipestem) fibrosis of mice. Acta Tropica, v. 98, n. 1, p.34-42, 2006.0001-706Xhttps://www.arca.fiocruz.br/handle/icict/275510.1016/j.actatropica.2006.01.011Agradecimentos a Sheilla Andrade de Oliveira, Rejane M.C. Menezes, Antonio Carlos S. Santos e Ana Cristina Gonzalez pelo apoio técnico e Brendan Flannery pela revisão do manuscrito.Este trabalho foi financiado pelo Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) e pela Fundação Oswaldo Cruz (FIOCRUZ).Fundação Oswaldo Cruz. Centro de Pesquis Gonçalo Moniz. Laboratórios de Patologia Experimental. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratórios de Patologia Experimental. Salvador, BA, BrasilMice chronically infected with Schistosoma mansoni develop one of two anatomical forms of hepatic lesions: severe, periportal (pipestem) fibrosis or milder, isolated granulomas. The pathogenesis of periportal fibrosis is poorly understood. In this work we compared mice with either periportal fibrosis or isolated granulomas to identify specific markers of severe pathology. BALB/c or Swiss Webster mice were infected with 30 cercarie, once or six times, and liver biopsies were performed to classify the animals into two pathological groups 16 weeks later. Sixty percent of the animals sacrificed at 20 or 24 weeks had periportal fibrosis, 15–20% had isolated granulomas and the remainder had indeterminate pathology. There was no correlation between frequency of infections or egg burden (eggs/g liver) at 20 and 24 weeks post-infection and the development of periportal fibrosis. Livers with periportal fibrosis at 20 or 24 weeks of infection were characterized by larger areas of fibrotic tissue and greater vascularization compared to livers of mice with isolated granulomas. Plastic casts of the portal vein system showed marked changes in vascular structure in mice with periportal fibrosis, including collateral vessels sprouting from the main portal branches, amputation of the more delicate peripheral ramifications, and distortions of the medium and small branches. Vascular changes were not observed in mice with isolated granulomas. These results suggest that the interaction between schistosome eggs and portal vascular changes is of paramount importance in the development of pipestem fibrosis.engSchistosoma mansoniFibrose PeriportalGranuloma PeriovularFibrose HepáticaSchistosoma mansoniPeriportal (pipestem) FibrosisPeriovular GranulomasHepatic FibrosisSchistosoma mansoniFibroseGranulomaCirrose HepáticaCharacterization of the vascular changes in schistosomal portal (pipestem) fibrosis of miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSilva_RibeirodosSantos_Soares_etal.pdfSilva_RibeirodosSantos_Soares_etal.pdfapplication/pdf574396https://www.arca.fiocruz.br/bitstream/icict/2755/1/Silva_RibeirodosSantos_Soares_etal.pdfabdce97e2694a013735492d9662ccfbeMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/2755/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTSilva_RibeirodosSantos_Soares_etal.pdf.txtSilva_RibeirodosSantos_Soares_etal.pdf.txtExtracted texttext/plain29503https://www.arca.fiocruz.br/bitstream/icict/2755/5/Silva_RibeirodosSantos_Soares_etal.pdf.txtdb75712233d3d33dd17a393ab33d4e76MD55THUMBNAILSilva_RibeirodosSantos_Soares_etal.pdf.jpgSilva_RibeirodosSantos_Soares_etal.pdf.jpgGenerated Thumbnailimage/jpeg1270https://www.arca.fiocruz.br/bitstream/icict/2755/4/Silva_RibeirodosSantos_Soares_etal.pdf.jpg108c6a98f5389918e4244f2b2ea64bf4MD54icict/27552023-03-15 14:33:08.34oai:www.arca.fiocruz.br:icict/2755Tk9OLUVYQ0xVU0lWRSBESVNUUklCVVRJT04gTElDRU5TRQoKQnkgc2lnbmluZyBhbmQgc3VibWl0dGluZyB0aGlzIGxpY2Vuc2UsIHlvdSAodGhlIGF1dGhvcihzKSBvciBjb3B5cmlnaHQKb3duZXIpIGdyYW50cyB0byBEU3BhY2UgVW5pdmVyc2l0eSAoRFNVKSB0aGUgbm9uLWV4Y2x1c2l2ZSByaWdodCB0byByZXByb2R1Y2UsCnRyYW5zbGF0ZSAoYXMgZGVmaW5lZCBiZWxvdyksIGFuZC9vciBkaXN0cmlidXRlIHlvdXIgc3VibWlzc2lvbiAoaW5jbHVkaW5nCnRoZSBhYnN0cmFjdCkgd29ybGR3aWRlIGluIHByaW50IGFuZCBlbGVjdHJvbmljIGZvcm1hdCBhbmQgaW4gYW55IG1lZGl1bSwKaW5jbHVkaW5nIGJ1dCBub3QgbGltaXRlZCB0byBhdWRpbyBvciB2aWRlby4KCllvdSBhZ3JlZSB0aGF0IERTVSBtYXksIHdpdGhvdXQgY2hhbmdpbmcgdGhlIGNvbnRlbnQsIHRyYW5zbGF0ZSB0aGUKc3VibWlzc2lvbiB0byBhbnkgbWVkaXVtIG9yIGZvcm1hdCBmb3IgdGhlIHB1cnBvc2Ugb2YgcHJlc2VydmF0aW9uLgoKWW91IGFsc28gYWdyZWUgdGhhdCBEU1UgbWF5IGtlZXAgbW9yZSB0aGFuIG9uZSBjb3B5IG9mIHRoaXMgc3VibWlzc2lvbiBmb3IKcHVycG9zZXMgb2Ygc2VjdXJpdHksIGJhY2stdXAgYW5kIHByZXNlcnZhdGlvbi4KCllvdSByZXByZXNlbnQgdGhhdCB0aGUgc3VibWlzc2lvbiBpcyB5b3VyIG9yaWdpbmFsIHdvcmssIGFuZCB0aGF0IHlvdSBoYXZlCnRoZSByaWdodCB0byBncmFudCB0aGUgcmlnaHRzIGNvbnRhaW5lZCBpbiB0aGlzIGxpY2Vuc2UuIFlvdSBhbHNvIHJlcHJlc2VudAp0aGF0IHlvdXIgc3VibWlzc2lvbiBkb2VzIG5vdCwgdG8gdGhlIGJlc3Qgb2YgeW91ciBrbm93bGVkZ2UsIGluZnJpbmdlIHVwb24KYW55b25lJ3MgY29weXJpZ2h0LgoKSWYgdGhlIHN1Ym1pc3Npb24gY29udGFpbnMgbWF0ZXJpYWwgZm9yIHdoaWNoIHlvdSBkbyBub3QgaG9sZCBjb3B5cmlnaHQsCnlvdSByZXByZXNlbnQgdGhhdCB5b3UgaGF2ZSBvYnRhaW5lZCB0aGUgdW5yZXN0cmljdGVkIHBlcm1pc3Npb24gb2YgdGhlCmNvcHlyaWdodCBvd25lciB0byBncmFudCBEU1UgdGhlIHJpZ2h0cyByZXF1aXJlZCBieSB0aGlzIGxpY2Vuc2UsIGFuZCB0aGF0CnN1Y2ggdGhpcmQtcGFydHkgb3duZWQgbWF0ZXJpYWwgaXMgY2xlYXJseSBpZGVudGlmaWVkIGFuZCBhY2tub3dsZWRnZWQKd2l0aGluIHRoZSB0ZXh0IG9yIGNvbnRlbnQgb2YgdGhlIHN1Ym1pc3Npb24uCgpJRiBUSEUgU1VCTUlTU0lPTiBJUyBCQVNFRCBVUE9OIFdPUksgVEhBVCBIQVMgQkVFTiBTUE9OU09SRUQgT1IgU1VQUE9SVEVECkJZIEFOIEFHRU5DWSBPUiBPUkdBTklaQVRJT04gT1RIRVIgVEhBTiBEU1UsIFlPVSBSRVBSRVNFTlQgVEhBVCBZT1UgSEFWRQpGVUxGSUxMRUQgQU5ZIFJJR0hUIE9GIFJFVklFVyBPUiBPVEhFUiBPQkxJR0FUSU9OUyBSRVFVSVJFRCBCWSBTVUNICkNPTlRSQUNUIE9SIEFHUkVFTUVOVC4KCkRTVSB3aWxsIGNsZWFybHkgaWRlbnRpZnkgeW91ciBuYW1lKHMpIGFzIHRoZSBhdXRob3Iocykgb3Igb3duZXIocykgb2YgdGhlCnN1Ym1pc3Npb24sIGFuZCB3aWxsIG5vdCBtYWtlIGFueSBhbHRlcmF0aW9uLCBvdGhlciB0aGFuIGFzIGFsbG93ZWQgYnkgdGhpcwpsaWNlbnNlLCB0byB5b3VyIHN1Ym1pc3Npb24uCg==Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:08Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Characterization of the vascular changes in schistosomal portal (pipestem) fibrosis of mice
title Characterization of the vascular changes in schistosomal portal (pipestem) fibrosis of mice
spellingShingle Characterization of the vascular changes in schistosomal portal (pipestem) fibrosis of mice
Silva, Luciana Menezes da
Schistosoma mansoni
Fibrose Periportal
Granuloma Periovular
Fibrose Hepática
Schistosoma mansoni
Periportal (pipestem) Fibrosis
Periovular Granulomas
Hepatic Fibrosis
Schistosoma mansoni
Fibrose
Granuloma
Cirrose Hepática
title_short Characterization of the vascular changes in schistosomal portal (pipestem) fibrosis of mice
title_full Characterization of the vascular changes in schistosomal portal (pipestem) fibrosis of mice
title_fullStr Characterization of the vascular changes in schistosomal portal (pipestem) fibrosis of mice
title_full_unstemmed Characterization of the vascular changes in schistosomal portal (pipestem) fibrosis of mice
title_sort Characterization of the vascular changes in schistosomal portal (pipestem) fibrosis of mice
author Silva, Luciana Menezes da
author_facet Silva, Luciana Menezes da
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
Andrade, Zilton de Araújo
author_role author
author2 Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
Andrade, Zilton de Araújo
author2_role author
author
author
dc.contributor.author.fl_str_mv Silva, Luciana Menezes da
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
Andrade, Zilton de Araújo
dc.subject.other.pt_BR.fl_str_mv Schistosoma mansoni
Fibrose Periportal
Granuloma Periovular
Fibrose Hepática
topic Schistosoma mansoni
Fibrose Periportal
Granuloma Periovular
Fibrose Hepática
Schistosoma mansoni
Periportal (pipestem) Fibrosis
Periovular Granulomas
Hepatic Fibrosis
Schistosoma mansoni
Fibrose
Granuloma
Cirrose Hepática
dc.subject.en.pt_BR.fl_str_mv Schistosoma mansoni
Periportal (pipestem) Fibrosis
Periovular Granulomas
Hepatic Fibrosis
dc.subject.decs.pt_BR.fl_str_mv Schistosoma mansoni
Fibrose
Granuloma
Cirrose Hepática
description Agradecimentos a Sheilla Andrade de Oliveira, Rejane M.C. Menezes, Antonio Carlos S. Santos e Ana Cristina Gonzalez pelo apoio técnico e Brendan Flannery pela revisão do manuscrito.
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2011-07-15T13:22:06Z
dc.date.available.fl_str_mv 2011-07-15T13:22:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, L. M. et al. Characterization of the vascular changes in schistosomal portal (pipestem) fibrosis of mice. Acta Tropica, v. 98, n. 1, p.34-42, 2006.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/2755
dc.identifier.issn.none.fl_str_mv 0001-706X
dc.identifier.doi.none.fl_str_mv 10.1016/j.actatropica.2006.01.011
identifier_str_mv SILVA, L. M. et al. Characterization of the vascular changes in schistosomal portal (pipestem) fibrosis of mice. Acta Tropica, v. 98, n. 1, p.34-42, 2006.
0001-706X
10.1016/j.actatropica.2006.01.011
url https://www.arca.fiocruz.br/handle/icict/2755
dc.language.iso.fl_str_mv eng
language eng
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