Tuberculosis treatment intermittency in the continuation phase and mortality in HIV-positive persons receiving antiretroviral therapy

Detalhes bibliográficos
Autor(a) principal: Crabtree-Ramirez, Brenda
Data de Publicação: 2022
Outros Autores: Jenkins, Cathy A., Shepherd, Bryan E., Jayathilake, Karu, Veloso, Valdiléa G., Carriquiry, Gabriela, Gotuzzo, Eduardo, Cortes, Claudia P., Padgett, Dennis, McGowan, Catherine, Sierra-Madero, Juan, Koenig, Serena, Pape, Jean W., Sterling, Timothy R., CCASAnet Region of IeDEA
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/52907
Resumo: CCASAnet Region of IeDEA: Pedro Cahn, Carina Cesar, Valeria Fink, Zulma Ortiz, Florencia Cahn, Agustina Roldan, Ines Aristegui, Claudia Frola, Beatriz Grinsztejn, Valdilea G Veloso, Paula M Luz, Sandra Cardoso Wagner, Ruth Friedman, Ronaldo I Moreira, Lara Esteves Coelho, Monica Derrico Pedrosa, Guilherme Amaral Calvet, Hugo Perazzo, Rodrigo Moreira, Maria Pia Diniz Ribeiro, Mario Sergio Pereira, Emilia Moreira Jalil, Jorge Pinto, Flavia Ferreira, Marcelle Maia, Aida de Fátima Barbosa Gouvêa, Fabiana do Carmo, Claudia Cortes, Marcelo Wolff, Maria Fernanda Rodriguez, Gabriel Castillo, Gladys Allendes, Jean William Pape, Vanessa Rouzier Adias Marcelin, Youry Macius, Stephano Saint Preux, Serena Koenig, Marco Tulio Luque Diana Varela, Magda Chavez, Ada Mailhot, Denis Padgett, Juan Sierra Madero, Brenda Crabtree Ramirez, Yanink Caro Vega, Eduardo Gotuzzo, Fernando Mejia, Gabriela Carriquiry, Catherine CMcGowan, Stephany N Duda, Bryan E Shepherd, Timothy Sterling, Anna K Person, Peter F Rebeiro, Jessica Castilho, William C Wester, Kate Clouse, Karu Jayathilake, Fernanda Maruri Hilary Vansell, Marina Cruvinel Figueiredo, Cathy Jenkins, Ahra Kim Sarah Lotspeich, Paridhi Ranadive, Kate Clouse
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spelling Crabtree-Ramirez, BrendaJenkins, Cathy A.Shepherd, Bryan E.Jayathilake, KaruVeloso, Valdiléa G.Carriquiry, GabrielaGotuzzo, EduardoCortes, Claudia P.Padgett, DennisMcGowan, CatherineSierra-Madero, JuanKoenig, SerenaPape, Jean W.Sterling, Timothy R.CCASAnet Region of IeDEA2022-05-25T23:27:43Z2022-05-25T23:27:43Z2022CRABTREE-RAMIREZ, Brenda et al. Tuberculosis treatment intermittency in the continuation phase and mortality in HIV-positive persons receiving antiretroviral therapy. BMC infectious diseases, v. 22, n. 1, p. 1-11, 20221471-2334https://www.arca.fiocruz.br/handle/icict/5290710.1186/s12879-022-07330-5CCASAnet Region of IeDEA: Pedro Cahn, Carina Cesar, Valeria Fink, Zulma Ortiz, Florencia Cahn, Agustina Roldan, Ines Aristegui, Claudia Frola, Beatriz Grinsztejn, Valdilea G Veloso, Paula M Luz, Sandra Cardoso Wagner, Ruth Friedman, Ronaldo I Moreira, Lara Esteves Coelho, Monica Derrico Pedrosa, Guilherme Amaral Calvet, Hugo Perazzo, Rodrigo Moreira, Maria Pia Diniz Ribeiro, Mario Sergio Pereira, Emilia Moreira Jalil, Jorge Pinto, Flavia Ferreira, Marcelle Maia, Aida de Fátima Barbosa Gouvêa, Fabiana do Carmo, Claudia Cortes, Marcelo Wolff, Maria Fernanda Rodriguez, Gabriel Castillo, Gladys Allendes, Jean William Pape, Vanessa Rouzier Adias Marcelin, Youry Macius, Stephano Saint Preux, Serena Koenig, Marco Tulio Luque Diana Varela, Magda Chavez, Ada Mailhot, Denis Padgett, Juan Sierra Madero, Brenda Crabtree Ramirez, Yanink Caro Vega, Eduardo Gotuzzo, Fernando Mejia, Gabriela Carriquiry, Catherine CMcGowan, Stephany N Duda, Bryan E Shepherd, Timothy Sterling, Anna K Person, Peter F Rebeiro, Jessica Castilho, William C Wester, Kate Clouse, Karu Jayathilake, Fernanda Maruri Hilary Vansell, Marina Cruvinel Figueiredo, Cathy Jenkins, Ahra Kim Sarah Lotspeich, Paridhi Ranadive, Kate ClouseInstituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán. Departamento de Infectología. Mexico City, Mexico.Vanderbilt University Medical Center. Nashville, TN, USA.Vanderbilt University Medical Center. Nashville, TN, USA.Vanderbilt University Medical Center. Nashville, TN, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Universidad Peruana Cayetano Heredia. Instituto de Medicina Tropical Alexander Von Humboldt. Lima, Peru.Universidad Peruana Cayetano Heredia. Instituto de Medicina Tropical Alexander Von Humboldt. Lima, Peru.University of Chile. Fundación Arriarán. Santiago, Chile.Hospital Escuela and Instituto Hondureño de Seguridad Social. Tegucigalpa, Honduras.Vanderbilt University Medical Center. Nashville, TN, USA.Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán. Departamento de Infectología. Mexico City, Mexico.Brigham and Women's Hospital. Division of Global Health Equity. Boston, MA, USA / Le Groupe Haïtien d'Etude du Sarcome de Kaposi Et Des Infections Opportunistes (GHESKIO). Port-au-Prince, Haiti.Le Groupe Haïtien d'Etude du Sarcome de Kaposi Et Des Infections Opportunistes (GHESKIO). Port-au-Prince, Haiti.Vanderbilt University Medical Center. Nashville, TN, USA.Background: Some tuberculosis (TB) treatment guidelines recommend daily TB treatment in both the intensive and continuation phases of treatment in HIV-positive persons to decrease the risk of relapse and acquired drug resistance. However, guidelines vary across countries, and treatment is given 7, 5, 3, or 2 days/week. The effect of TB treatment intermittency in the continuation phase on mortality in HIV-positive persons on antiretroviral therapy (ART), is not well-described. Methods: We conducted an observational cohort study among HIV-positive adults treated for TB between 2000 and 2018 and after enrollment into the Caribbean, Central, and South America network for HIV epidemiology (CCASAnet; Brazil, Chile, Haiti, Honduras, Mexico and Peru). All received standard TB therapy (2-month initiation phase of daily isoniazid, rifampin or rifabutin, pyrazinamide ± ethambutol) and continuation phase of isoniazid and rifampin or rifabutin, administered concomitantly with ART. Known timing of ART and TB treatment were also inclusion criteria. Kaplan-Meier and Cox proportional hazards methods compared time to death between groups. Missing model covariates were imputed via multiple imputation. Results: 2303 patients met inclusion criteria: 2003(87%) received TB treatment 5-7 days/week and 300(13%) 2-3 days/week in the continuation phase. Intermittency varied by site: 100% of patients from Brazil and Haiti received continuation phase treatment 5-7 days/week, followed by Honduras (91%), Peru (42%), Mexico (7%), and Chile (0%). The crude risk of death was lower among those receiving treatment 5-7 vs. 2-3 days/week (HR = 0.68; 95% CI = 0.51-0.91; P = 0.008). After adjusting for age, sex, CD4, ART use at TB diagnosis, site of TB disease (pulmonary vs. extrapulmonary), and year of TB diagnosis, mortality risk was lower, but not significantly, among those treated 5-7 days/week vs. 2-3 days/week (HR 0.75, 95%CI 0.55-1.01; P = 0.06). After also stratifying by study site, there was no longer a protective effect (HR 1.42, 95%CI 0.83-2.45; P = 0.20). Conclusions: TB treatment 5-7 days/week was associated with a marginally decreased risk of death compared to TB treatment 2-3 days/week in the continuation phase in multivariable, unstratified analyses. However, little variation in TB treatment intermittency within country meant the results could have been driven by other differences between study sites. Therefore, randomized trials are needed, especially in heterogenous regions such as Latin America.engBMCTuberculosis treatment intermittency in the continuation phase and mortality in HIV-positive persons receiving antiretroviral therapyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleARTHIVIntermittent treatmentTB maintenance treatmentTuberculosisTuberculosis treatmentinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/52907/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALTuberculosis_Valdilea_Veloso_etal_INI_2022.pdfTuberculosis_Valdilea_Veloso_etal_INI_2022.pdfapplication/pdf1033543https://www.arca.fiocruz.br/bitstream/icict/52907/2/Tuberculosis_Valdilea_Veloso_etal_INI_2022.pdf7e55dfccac4544b62f1470873c6ac4a3MD52icict/529072022-05-25 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dc.title.pt_BR.fl_str_mv Tuberculosis treatment intermittency in the continuation phase and mortality in HIV-positive persons receiving antiretroviral therapy
title Tuberculosis treatment intermittency in the continuation phase and mortality in HIV-positive persons receiving antiretroviral therapy
spellingShingle Tuberculosis treatment intermittency in the continuation phase and mortality in HIV-positive persons receiving antiretroviral therapy
Crabtree-Ramirez, Brenda
ART
HIV
Intermittent treatment
TB maintenance treatment
Tuberculosis
Tuberculosis treatment
title_short Tuberculosis treatment intermittency in the continuation phase and mortality in HIV-positive persons receiving antiretroviral therapy
title_full Tuberculosis treatment intermittency in the continuation phase and mortality in HIV-positive persons receiving antiretroviral therapy
title_fullStr Tuberculosis treatment intermittency in the continuation phase and mortality in HIV-positive persons receiving antiretroviral therapy
title_full_unstemmed Tuberculosis treatment intermittency in the continuation phase and mortality in HIV-positive persons receiving antiretroviral therapy
title_sort Tuberculosis treatment intermittency in the continuation phase and mortality in HIV-positive persons receiving antiretroviral therapy
author Crabtree-Ramirez, Brenda
author_facet Crabtree-Ramirez, Brenda
Jenkins, Cathy A.
Shepherd, Bryan E.
Jayathilake, Karu
Veloso, Valdiléa G.
Carriquiry, Gabriela
Gotuzzo, Eduardo
Cortes, Claudia P.
Padgett, Dennis
McGowan, Catherine
Sierra-Madero, Juan
Koenig, Serena
Pape, Jean W.
Sterling, Timothy R.
CCASAnet Region of IeDEA
author_role author
author2 Jenkins, Cathy A.
Shepherd, Bryan E.
Jayathilake, Karu
Veloso, Valdiléa G.
Carriquiry, Gabriela
Gotuzzo, Eduardo
Cortes, Claudia P.
Padgett, Dennis
McGowan, Catherine
Sierra-Madero, Juan
Koenig, Serena
Pape, Jean W.
Sterling, Timothy R.
CCASAnet Region of IeDEA
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Crabtree-Ramirez, Brenda
Jenkins, Cathy A.
Shepherd, Bryan E.
Jayathilake, Karu
Veloso, Valdiléa G.
Carriquiry, Gabriela
Gotuzzo, Eduardo
Cortes, Claudia P.
Padgett, Dennis
McGowan, Catherine
Sierra-Madero, Juan
Koenig, Serena
Pape, Jean W.
Sterling, Timothy R.
CCASAnet Region of IeDEA
dc.subject.en.pt_BR.fl_str_mv ART
HIV
Intermittent treatment
TB maintenance treatment
Tuberculosis
Tuberculosis treatment
topic ART
HIV
Intermittent treatment
TB maintenance treatment
Tuberculosis
Tuberculosis treatment
description CCASAnet Region of IeDEA: Pedro Cahn, Carina Cesar, Valeria Fink, Zulma Ortiz, Florencia Cahn, Agustina Roldan, Ines Aristegui, Claudia Frola, Beatriz Grinsztejn, Valdilea G Veloso, Paula M Luz, Sandra Cardoso Wagner, Ruth Friedman, Ronaldo I Moreira, Lara Esteves Coelho, Monica Derrico Pedrosa, Guilherme Amaral Calvet, Hugo Perazzo, Rodrigo Moreira, Maria Pia Diniz Ribeiro, Mario Sergio Pereira, Emilia Moreira Jalil, Jorge Pinto, Flavia Ferreira, Marcelle Maia, Aida de Fátima Barbosa Gouvêa, Fabiana do Carmo, Claudia Cortes, Marcelo Wolff, Maria Fernanda Rodriguez, Gabriel Castillo, Gladys Allendes, Jean William Pape, Vanessa Rouzier Adias Marcelin, Youry Macius, Stephano Saint Preux, Serena Koenig, Marco Tulio Luque Diana Varela, Magda Chavez, Ada Mailhot, Denis Padgett, Juan Sierra Madero, Brenda Crabtree Ramirez, Yanink Caro Vega, Eduardo Gotuzzo, Fernando Mejia, Gabriela Carriquiry, Catherine CMcGowan, Stephany N Duda, Bryan E Shepherd, Timothy Sterling, Anna K Person, Peter F Rebeiro, Jessica Castilho, William C Wester, Kate Clouse, Karu Jayathilake, Fernanda Maruri Hilary Vansell, Marina Cruvinel Figueiredo, Cathy Jenkins, Ahra Kim Sarah Lotspeich, Paridhi Ranadive, Kate Clouse
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-05-25T23:27:43Z
dc.date.available.fl_str_mv 2022-05-25T23:27:43Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv CRABTREE-RAMIREZ, Brenda et al. Tuberculosis treatment intermittency in the continuation phase and mortality in HIV-positive persons receiving antiretroviral therapy. BMC infectious diseases, v. 22, n. 1, p. 1-11, 2022
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/52907
dc.identifier.issn.pt_BR.fl_str_mv 1471-2334
dc.identifier.doi.none.fl_str_mv 10.1186/s12879-022-07330-5
identifier_str_mv CRABTREE-RAMIREZ, Brenda et al. Tuberculosis treatment intermittency in the continuation phase and mortality in HIV-positive persons receiving antiretroviral therapy. BMC infectious diseases, v. 22, n. 1, p. 1-11, 2022
1471-2334
10.1186/s12879-022-07330-5
url https://www.arca.fiocruz.br/handle/icict/52907
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/52907/1/license.txt
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