Controlling the seedbeds of tuberculosis: diagnosis and treatment of tuberculosis infection

Detalhes bibliográficos
Autor(a) principal: Rangaka, Molebogeng X.
Data de Publicação: 2015
Outros Autores: Cavalcante, Solange C., Marais, Ben J., Thim, Sok, Martinson, Neil A., Swaminathan, Soumya, Chaisson, Richard E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/34920
Resumo: University College London. Institute of Epidemiology and Health. London, UK / University of Cape Town. Institute of Infectious Disease and Molecular Medicine. Cape Town, South Africa.
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spelling Rangaka, Molebogeng X.Cavalcante, Solange C.Marais, Ben J.Thim, SokMartinson, Neil A.Swaminathan, SoumyaChaisson, Richard E.2019-08-21T13:52:01Z2019-08-21T13:52:01Z2015RANGAKA, Molebogeng X. et al. Controlling the seedbeds of tuberculosis: diagnosis and treatment of tuberculosis infection. Lancet, v. 386, p. 2344-2353, Dec. 2015.2468-2667https://www.arca.fiocruz.br/handle/icict/3492010.1016/S0140-6736(15)00323-2engElsevierControlling the seedbeds of tuberculosis: diagnosis and treatment of tuberculosis infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity College London. Institute of Epidemiology and Health. London, UK / University of Cape Town. Institute of Infectious Disease and Molecular Medicine. Cape Town, South Africa.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.University of Sydney. Children’s Hospital at Westmead. Sydney, Australia / Centre for Research Excellence in Tuberculosis. Sydney, Australia.Cambodian Health Committee. Phnom Penh, Cambodia.University of Witwatersrand. Perinatal HIV Research Unit. Soweto, South Africa.National Institute for Research on Tuberculosis. Chennai, India.Johns Hopkins University. School of Medicine. Center for Tuberculosis Research. Baltimore, MD, USA.The billions of people with latent tuberculosis infection serve as the seedbeds for future cases of active tuberculosis. Virtually all episodes of tuberculosis disease are preceded by a period of asymptomatic Mycobacterium tuberculosis infection; therefore, identifying infected individuals most likely to progress to disease and treating such subclinical infections to prevent future disease provides a crucial opportunity to interrupt tuberculosis transmission and reduce the global burden of tuberculosis disease. Programmes focusing on single strategies rather than comprehensive programmes that deliver an integrated arsenal for tuberculosis control might continue to struggle. Tuberculosis preventive therapy is a poorly used method that is essential for controlling the reservoirs of disease that drive the epidemic. Comprehensive control strategies that combine preventive therapy for the most high-risk populations and communities with improved case-fi nding and treatment, control of transmission, and health systems strengthening could ultimately lead to worldwide tuberculosis elimination. In this Series paper we outline challenges to implementation of preventive therapy and provide pragmatic suggestions for overcoming them. We further advocate for tuberculosis preventive therapy as the core of a renewed worldwide focus to implement a comprehensive epidemic control strategy that would reduce new tuberculosis cases to elimination targets. This strategy would be underpinned by accelerated research to further understand the biology of subclinical tuberculosis infections, develop novel diagnostics and drug regimens specifi cally for subclinical tuberculosis infection, strengthen health systems and community engagement, and enhance sustainable large scale implementation of preventive therapy programmes.TuberculosisTuberculosis infectionTreatmentinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/34920/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Molebogeng_Rangaka_etal_INI_2105.pdfve_Molebogeng_Rangaka_etal_INI_2105.pdfapplication/pdf210482https://www.arca.fiocruz.br/bitstream/icict/34920/2/ve_Molebogeng_Rangaka_etal_INI_2105.pdf16686d418d75ede7047f3e4fb7ff27c6MD52TEXTve_Molebogeng_Rangaka_etal_INI_2105.pdf.txtve_Molebogeng_Rangaka_etal_INI_2105.pdf.txtExtracted texttext/plain61888https://www.arca.fiocruz.br/bitstream/icict/34920/3/ve_Molebogeng_Rangaka_etal_INI_2105.pdf.txtb3acdbb6014f9c265ab7e4580aa3b5d2MD53icict/349202019-08-22 02:03:46.323oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-08-22T05:03:46Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Controlling the seedbeds of tuberculosis: diagnosis and treatment of tuberculosis infection
title Controlling the seedbeds of tuberculosis: diagnosis and treatment of tuberculosis infection
spellingShingle Controlling the seedbeds of tuberculosis: diagnosis and treatment of tuberculosis infection
Rangaka, Molebogeng X.
Tuberculosis
Tuberculosis infection
Treatment
title_short Controlling the seedbeds of tuberculosis: diagnosis and treatment of tuberculosis infection
title_full Controlling the seedbeds of tuberculosis: diagnosis and treatment of tuberculosis infection
title_fullStr Controlling the seedbeds of tuberculosis: diagnosis and treatment of tuberculosis infection
title_full_unstemmed Controlling the seedbeds of tuberculosis: diagnosis and treatment of tuberculosis infection
title_sort Controlling the seedbeds of tuberculosis: diagnosis and treatment of tuberculosis infection
author Rangaka, Molebogeng X.
author_facet Rangaka, Molebogeng X.
Cavalcante, Solange C.
Marais, Ben J.
Thim, Sok
Martinson, Neil A.
Swaminathan, Soumya
Chaisson, Richard E.
author_role author
author2 Cavalcante, Solange C.
Marais, Ben J.
Thim, Sok
Martinson, Neil A.
Swaminathan, Soumya
Chaisson, Richard E.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rangaka, Molebogeng X.
Cavalcante, Solange C.
Marais, Ben J.
Thim, Sok
Martinson, Neil A.
Swaminathan, Soumya
Chaisson, Richard E.
dc.subject.en.pt_BR.fl_str_mv Tuberculosis
Tuberculosis infection
Treatment
topic Tuberculosis
Tuberculosis infection
Treatment
description University College London. Institute of Epidemiology and Health. London, UK / University of Cape Town. Institute of Infectious Disease and Molecular Medicine. Cape Town, South Africa.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2019-08-21T13:52:01Z
dc.date.available.fl_str_mv 2019-08-21T13:52:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RANGAKA, Molebogeng X. et al. Controlling the seedbeds of tuberculosis: diagnosis and treatment of tuberculosis infection. Lancet, v. 386, p. 2344-2353, Dec. 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/34920
dc.identifier.issn.pt_BR.fl_str_mv 2468-2667
dc.identifier.doi.none.fl_str_mv 10.1016/S0140-6736(15)00323-2
identifier_str_mv RANGAKA, Molebogeng X. et al. Controlling the seedbeds of tuberculosis: diagnosis and treatment of tuberculosis infection. Lancet, v. 386, p. 2344-2353, Dec. 2015.
2468-2667
10.1016/S0140-6736(15)00323-2
url https://www.arca.fiocruz.br/handle/icict/34920
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
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