High-throughput mass spectrometry and bioinformatics analysis of breast cancer proteomic data

Detalhes bibliográficos
Autor(a) principal: Gomig, Talita Helen Bombardelli
Data de Publicação: 2019
Outros Autores: Cavalli, Iglenir João, Souza, Ricardo Lehtonen Rodrigues de, Lucena, Aline Castro Rodrigues, Batista, Michel, Machado, Kelly Cavalcanti, Marchini, Fabrício Klerynton, Marchi, Fabio Albuquerque, Lima, Rubens Silveira, Urban, Cícero de Andrade, Cavalli, Luciane Regina, Ribeiro, Enilze Maria de Souza Fonseca
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/34613
Resumo: Universidade Federal do Paraná. Departamento de Genética. Curitiba, PR, Brasil.
id CRUZ_1db07e75d52a5e09ee1655fc6fc00c4b
oai_identifier_str oai:www.arca.fiocruz.br:icict/34613
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Gomig, Talita Helen BombardelliCavalli, Iglenir JoãoSouza, Ricardo Lehtonen Rodrigues deLucena, Aline Castro RodriguesBatista, MichelMachado, Kelly CavalcantiMarchini, Fabrício KleryntonMarchi, Fabio AlbuquerqueLima, Rubens SilveiraUrban, Cícero de AndradeCavalli, Luciane ReginaRibeiro, Enilze Maria de Souza Fonseca2019-08-05T18:53:58Z2019-08-05T18:53:58Z2019GOMIG, Talita Helen Bombardelli et al. High-throughput mass spectrometry and bioinformatics analysis of breast câncer proteomic data. Data in Brief, v. 25, p. 1-5, 2019.2352-3409https://www.arca.fiocruz.br/handle/icict/3461310.1016/j.dib.2019.1041252352-3409porElsevierTecido Mamário Não Tumoral ContralateralBreast NeoplasmsBioinformaticsComputational BiologyMass SpectrometryContralateral Non-Tumor Breast TissueNeoplasias de la MamaBiología ComputacionalEspectrometría de MasasNeoplasias da MamaBiologia ComputacionalEspectrometria de MassasHigh-throughput mass spectrometry and bioinformatics analysis of breast cancer proteomic datainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Paraná. Departamento de Genética. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Genética. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Genômica Funcional. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Genômica Funcional. Curitiba, PR, Brasil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Mass Spectrometry Facility - RPT02H. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Mass Spectrometry Facility - RPT02H. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Genômica Funcional. Curitiba, PR, Brasil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Mass Spectrometry Facility - RPT02H. Curitiba, PR, Brasil.International Research Center and A.C. Camargo Cancer Center. São Paulo, SP, Brasil.Hospital Nossa Senhora das Graças. Centro de Doenças da Mama. Curitiba, PR, Brasil.Hospital Nossa Senhora das Graças. Centro de Doenças da Mama. Curitiba, PR, Brasil.Instituto de Pesquisa Pelé Pequeno Príncipe. Curitiba, PR, Brasil. / Lombardi Comprehensive Cancer Center. Georgetown University. Washington D.C., USA.Universidade Federal do Paraná. Departamento de Genética. Curitiba, PR, Brasil.Data present here describe a comparative proteomic analysis among the malignant [primary breast tumor (PT) and axillary metastatic lymph nodes (LN)], and the non-tumor [contralateral (NCT) and adjacent (ANT)] breast tissues. Protein identification and quantification were performed through label-free mass spectrometry using a nano-liquid chromatography coupled to an electrospray ionization-mass spectrometry (nLC-ESI-MS/MS). The mass spectrometry proteomic data have been deposited to the ProteomeXchange Consortium via PRIDE partner repository with the dataset identifier PXD012431. A total of 462 differentially expressed proteins was identified among these tissues and was analyzed in six groups' comparisons (named NCTxANT, PTxNCT, PTxANT, LNxNCT, LNxANT and PTxLN). Proteins at 1.5 log2 fold change were submitted to the Ingenuity® Pathway Analysis (IPA) software version 2.3 (QIAGEN Inc.) to identify biological pathways, disease and function annotation, and interaction networks related to cancer biology. The detailed data present here provides information about the proteome alterations and their role on breast tumorigenesis. This information can lead to novel biological insights on cancer research. For further interpretation of these data, please see our research article 'Quantitative label-free mass spectrometry using contralateral and adjacent breast tissues reveal differentially expressed proteins and their predicted impacts on pathways and cellular functions in breast cancer.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/34613/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALS2352340919304792-main.pdfS2352340919304792-main.pdfapplication/pdf682363https://www.arca.fiocruz.br/bitstream/icict/34613/2/S2352340919304792-main.pdff56c0dc497a7f45ba4247e43ea03c4f5MD52TEXTS2352340919304792-main.pdf.txtS2352340919304792-main.pdf.txtExtracted texttext/plain15448https://www.arca.fiocruz.br/bitstream/icict/34613/3/S2352340919304792-main.pdf.txt59a836cc240e3d48a6587952faf54252MD53icict/346132019-10-31 16:57:04.5oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-10-31T19:57:04Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv High-throughput mass spectrometry and bioinformatics analysis of breast cancer proteomic data
title High-throughput mass spectrometry and bioinformatics analysis of breast cancer proteomic data
spellingShingle High-throughput mass spectrometry and bioinformatics analysis of breast cancer proteomic data
Gomig, Talita Helen Bombardelli
Tecido Mamário Não Tumoral Contralateral
Breast Neoplasms
Bioinformatics
Computational Biology
Mass Spectrometry
Contralateral Non-Tumor Breast Tissue
Neoplasias de la Mama
Biología Computacional
Espectrometría de Masas
Neoplasias da Mama
Biologia Computacional
Espectrometria de Massas
title_short High-throughput mass spectrometry and bioinformatics analysis of breast cancer proteomic data
title_full High-throughput mass spectrometry and bioinformatics analysis of breast cancer proteomic data
title_fullStr High-throughput mass spectrometry and bioinformatics analysis of breast cancer proteomic data
title_full_unstemmed High-throughput mass spectrometry and bioinformatics analysis of breast cancer proteomic data
title_sort High-throughput mass spectrometry and bioinformatics analysis of breast cancer proteomic data
author Gomig, Talita Helen Bombardelli
author_facet Gomig, Talita Helen Bombardelli
Cavalli, Iglenir João
Souza, Ricardo Lehtonen Rodrigues de
Lucena, Aline Castro Rodrigues
Batista, Michel
Machado, Kelly Cavalcanti
Marchini, Fabrício Klerynton
Marchi, Fabio Albuquerque
Lima, Rubens Silveira
Urban, Cícero de Andrade
Cavalli, Luciane Regina
Ribeiro, Enilze Maria de Souza Fonseca
author_role author
author2 Cavalli, Iglenir João
Souza, Ricardo Lehtonen Rodrigues de
Lucena, Aline Castro Rodrigues
Batista, Michel
Machado, Kelly Cavalcanti
Marchini, Fabrício Klerynton
Marchi, Fabio Albuquerque
Lima, Rubens Silveira
Urban, Cícero de Andrade
Cavalli, Luciane Regina
Ribeiro, Enilze Maria de Souza Fonseca
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gomig, Talita Helen Bombardelli
Cavalli, Iglenir João
Souza, Ricardo Lehtonen Rodrigues de
Lucena, Aline Castro Rodrigues
Batista, Michel
Machado, Kelly Cavalcanti
Marchini, Fabrício Klerynton
Marchi, Fabio Albuquerque
Lima, Rubens Silveira
Urban, Cícero de Andrade
Cavalli, Luciane Regina
Ribeiro, Enilze Maria de Souza Fonseca
dc.subject.other.pt_BR.fl_str_mv Tecido Mamário Não Tumoral Contralateral
topic Tecido Mamário Não Tumoral Contralateral
Breast Neoplasms
Bioinformatics
Computational Biology
Mass Spectrometry
Contralateral Non-Tumor Breast Tissue
Neoplasias de la Mama
Biología Computacional
Espectrometría de Masas
Neoplasias da Mama
Biologia Computacional
Espectrometria de Massas
dc.subject.en.pt_BR.fl_str_mv Breast Neoplasms
Bioinformatics
Computational Biology
Mass Spectrometry
Contralateral Non-Tumor Breast Tissue
dc.subject.es.pt_BR.fl_str_mv Neoplasias de la Mama
Biología Computacional
Espectrometría de Masas
dc.subject.decs.pt_BR.fl_str_mv Neoplasias da Mama
Biologia Computacional
Espectrometria de Massas
description Universidade Federal do Paraná. Departamento de Genética. Curitiba, PR, Brasil.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-08-05T18:53:58Z
dc.date.available.fl_str_mv 2019-08-05T18:53:58Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GOMIG, Talita Helen Bombardelli et al. High-throughput mass spectrometry and bioinformatics analysis of breast câncer proteomic data. Data in Brief, v. 25, p. 1-5, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/34613
dc.identifier.issn.pt_BR.fl_str_mv 2352-3409
dc.identifier.doi.none.fl_str_mv 10.1016/j.dib.2019.104125
dc.identifier.eissn.none.fl_str_mv 2352-3409
identifier_str_mv GOMIG, Talita Helen Bombardelli et al. High-throughput mass spectrometry and bioinformatics analysis of breast câncer proteomic data. Data in Brief, v. 25, p. 1-5, 2019.
2352-3409
10.1016/j.dib.2019.104125
url https://www.arca.fiocruz.br/handle/icict/34613
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/34613/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/34613/2/S2352340919304792-main.pdf
https://www.arca.fiocruz.br/bitstream/icict/34613/3/S2352340919304792-main.pdf.txt
bitstream.checksum.fl_str_mv 783568c2893d2e25a99990b126be1772
f56c0dc497a7f45ba4247e43ea03c4f5
59a836cc240e3d48a6587952faf54252
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009069963739136

Registros relacionados