Vertical HIV-1 transmission: importance of neutralizing antibody titer and specificity
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2001 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31353 |
Resumo: | Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Department of Immunology. AIDS & Molecular Immunology Laboratory. Rio de Janeiro, RJ, Brazil. |
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Bongertz, V.Costa, C. I.Veloso, V. G.Grinsztejn, BeatrizJoão Filho, E. C.Calvet, G.Pilotto, J. H.Guimarães, M. L.Morgado, M. G.2019-01-30T10:39:22Z2019-01-30T10:39:22Z2001BONGERTZ, V. et al. Vertical HIV-1 Transmission: Importance of neutralizing antibody titer and specificity. Scandinavian Journal of Immunology, v. 53, p. 302-309, 2001.0300-9475https://www.arca.fiocruz.br/handle/icict/3135310.1046/j.1365-3083.2001.00866.xengVertical HIV-1 transmission: importance of neutralizing antibody titer and specificityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleOswaldo Cruz Foundation. Oswaldo Cruz Institute. Department of Immunology. AIDS & Molecular Immunology Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Department of Immunology. AIDS & Molecular Immunology Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas Hospital Research Center. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas Hospital Research Center. Rio de Janeiro, RJ, Brazil.Servidores do Estado Hospital. Rio de Janeiro, RJ, Brazil.Servidores do Estado Hospital. Rio de Janeiro, RJ, Brazil.Nova Iguaçu General Hospital. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Department of Immunology. AIDS & Molecular Immunology Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Department of Immunology. AIDS & Molecular Immunology Laboratory. Rio de Janeiro, RJ, Brazil.Neutralization analyses were carried out with plasma from 132 volunteer human immunodeficiency virus (HIV)-1 infected women (76% pregnant, 24% with infants suspected for HIV-1 infection) collected between 1994 and 1998, against autologous and heterologous primary- and the reference HIV-1 MN isolates. A significantly lower percentage of HIV-1 transmissions was observed after 1996, parallel to a more intense antiretroviral treatment of infected pregnant women. HIV-1 isolation was significantly more frequent from peripheral blood mononuclear cells of mothers of infected children than mothers of uninfected children (P = 0.0065). Neutralization of autologous HIV-1 isolates was comparable for HIV-1 transmitters and nontransmitters' plasma, whereas neutralization of the reference isolate HIV-1 MN was more frequent at high titers for pregnant women who did not transmit HIV to their offspring compared to pregnant women who did. Although neutralization of heterologous primary HIV-1 isolates from HIV transmitters and non transmitters by transmitter plasma occurred with similar frequency, neutralization of isolates from transmitters was much more frequent when heterologous plasma from nontransmitters were used. Macrophage-tropic heterologous HIV-1 isolates were neutralized more frequently at higher titers by plasma from nontransmitters than from transmitters. The results obtained indicate that antiretroviral treatment, lack of success of HIV-1 isolation and high titers of antibodies able to neutralize macrophage-tropic viruses appear to be of importance for protection against HIV-1 vertical transmission for the group of patients studied.Vertical HIV-1 transmissionHIVEpidemicNeutralizing antibodyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/31353/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALve_Bongertz_V_etal_INI_2001.pdfve_Bongertz_V_etal_INI_2001.pdfapplication/pdf181928https://www.arca.fiocruz.br/bitstream/icict/31353/2/ve_Bongertz_V_etal_INI_2001.pdf72445e7c85da9ed3d5063b257b2665f5MD52TEXTve_Bongertz_V_etal_INI_2001.pdf.txtve_Bongertz_V_etal_INI_2001.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Vertical HIV-1 transmission: importance of neutralizing antibody titer and specificity |
| title |
Vertical HIV-1 transmission: importance of neutralizing antibody titer and specificity |
| spellingShingle |
Vertical HIV-1 transmission: importance of neutralizing antibody titer and specificity Bongertz, V. Vertical HIV-1 transmission HIV Epidemic Neutralizing antibody |
| title_short |
Vertical HIV-1 transmission: importance of neutralizing antibody titer and specificity |
| title_full |
Vertical HIV-1 transmission: importance of neutralizing antibody titer and specificity |
| title_fullStr |
Vertical HIV-1 transmission: importance of neutralizing antibody titer and specificity |
| title_full_unstemmed |
Vertical HIV-1 transmission: importance of neutralizing antibody titer and specificity |
| title_sort |
Vertical HIV-1 transmission: importance of neutralizing antibody titer and specificity |
| author |
Bongertz, V. |
| author_facet |
Bongertz, V. Costa, C. I. Veloso, V. G. Grinsztejn, Beatriz João Filho, E. C. Calvet, G. Pilotto, J. H. Guimarães, M. L. Morgado, M. G. |
| author_role |
author |
| author2 |
Costa, C. I. Veloso, V. G. Grinsztejn, Beatriz João Filho, E. C. Calvet, G. Pilotto, J. H. Guimarães, M. L. Morgado, M. G. |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bongertz, V. Costa, C. I. Veloso, V. G. Grinsztejn, Beatriz João Filho, E. C. Calvet, G. Pilotto, J. H. Guimarães, M. L. Morgado, M. G. |
| dc.subject.en.pt_BR.fl_str_mv |
Vertical HIV-1 transmission HIV Epidemic Neutralizing antibody |
| topic |
Vertical HIV-1 transmission HIV Epidemic Neutralizing antibody |
| description |
Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Department of Immunology. AIDS & Molecular Immunology Laboratory. Rio de Janeiro, RJ, Brazil. |
| publishDate |
2001 |
| dc.date.issued.fl_str_mv |
2001 |
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2019-01-30T10:39:22Z |
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2019-01-30T10:39:22Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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BONGERTZ, V. et al. Vertical HIV-1 Transmission: Importance of neutralizing antibody titer and specificity. Scandinavian Journal of Immunology, v. 53, p. 302-309, 2001. |
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https://www.arca.fiocruz.br/handle/icict/31353 |
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0300-9475 |
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10.1046/j.1365-3083.2001.00866.x |
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BONGERTZ, V. et al. Vertical HIV-1 Transmission: Importance of neutralizing antibody titer and specificity. Scandinavian Journal of Immunology, v. 53, p. 302-309, 2001. 0300-9475 10.1046/j.1365-3083.2001.00866.x |
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