Frequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter polymorphisms among distinct ethnic groups from Brazil

Detalhes bibliográficos
Autor(a) principal: Fertrin, Kleber Yotsumoto
Data de Publicação: 2002
Outros Autores: Gonçalves, Marilda de Souza, Saad, Sara Teresinha Olalla, Costa, Fernando Ferreira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/19359
Resumo: Marilda de Souza Gonçalves “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Fertrin, Kleber YotsumotoGonçalves, Marilda de SouzaSaad, Sara Teresinha OlallaCosta, Fernando Ferreira2017-06-09T17:18:52Z2017-06-09T17:18:52Z2002FERTRIN, K. Y. et al. Frequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter polymorphisms among distinct ethnic groups from Brazil. American Journal of Medical Genetics Part A, v. 108, p. 117-119, 2002.1552-4825https://www.arca.fiocruz.br/handle/icict/19359Marilda de Souza Gonçalves “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.?%"6 " ? @ A % B " 4 6 A " C > '5"4 ' 5 FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo) e CNPq (Conselho Nacional de Desenvolvimento Científico e Pesquisa)Unicamp. Hemocentro. Cidade Universitária Zeferino Vaz. Campinas, SP, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilUnicamp. Hemocentro. Cidade Universitária Zeferino Vaz. Campinas, SP, BrasilUnicamp. Hemocentro. Cidade Universitária Zeferino Vaz. Campinas, SP, BrasilA polymorphism in the promoter region of the UDP-glucuronosyltransferase 1 (UGT1A) gene is associated with Gilbert syndrome (GS), a benign form of mild unconjugated hyperbilirubinemia. We genotyped 157 individuals from Brazil, comprising 71 Caucasians, 54 African-derived subjects, and 32 Parakanã Indians. Frequencies of the alelle (TA)(7) associated with GS found in this study were 0.324, 0.407, and 0.328, respectively. The genotype frequencies differed significantly between Caucasians and African-derived individuals. The high frequencies of (TA)(7) polymorphism among the three groups confirm previous data that this polymorphism is very ancient and appears to be distributed throughout the world.engWileyGlucuronosiltransferasePolimorfismo (genética)Regiões promotoras, genéticaGrupos etnicosAlelosBrazilGilbert syndromeUGT1ATA polymorphismAmerindiansParakanã indiansGlucuronosiltransferasePolimorfismo (genética)Regiões promotoras, genéticaGrupos etnicosAlelosBrazilFrequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter polymorphisms among distinct ethnic groups from Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19359/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFertrin KY Frequencies of UDP....pdfFertrin KY 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dc.title.pt_BR.fl_str_mv Frequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter polymorphisms among distinct ethnic groups from Brazil
title Frequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter polymorphisms among distinct ethnic groups from Brazil
spellingShingle Frequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter polymorphisms among distinct ethnic groups from Brazil
Fertrin, Kleber Yotsumoto
Glucuronosiltransferase
Polimorfismo (genética)
Regiões promotoras, genética
Grupos etnicos
Alelos
Brazil
Gilbert syndrome
UGT1A
TA polymorphism
Amerindians
Parakanã indians
Glucuronosiltransferase
Polimorfismo (genética)
Regiões promotoras, genética
Grupos etnicos
Alelos
Brazil
title_short Frequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter polymorphisms among distinct ethnic groups from Brazil
title_full Frequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter polymorphisms among distinct ethnic groups from Brazil
title_fullStr Frequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter polymorphisms among distinct ethnic groups from Brazil
title_full_unstemmed Frequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter polymorphisms among distinct ethnic groups from Brazil
title_sort Frequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter polymorphisms among distinct ethnic groups from Brazil
author Fertrin, Kleber Yotsumoto
author_facet Fertrin, Kleber Yotsumoto
Gonçalves, Marilda de Souza
Saad, Sara Teresinha Olalla
Costa, Fernando Ferreira
author_role author
author2 Gonçalves, Marilda de Souza
Saad, Sara Teresinha Olalla
Costa, Fernando Ferreira
author2_role author
author
author
dc.contributor.author.fl_str_mv Fertrin, Kleber Yotsumoto
Gonçalves, Marilda de Souza
Saad, Sara Teresinha Olalla
Costa, Fernando Ferreira
dc.subject.other.pt_BR.fl_str_mv Glucuronosiltransferase
Polimorfismo (genética)
Regiões promotoras, genética
Grupos etnicos
Alelos
Brazil
topic Glucuronosiltransferase
Polimorfismo (genética)
Regiões promotoras, genética
Grupos etnicos
Alelos
Brazil
Gilbert syndrome
UGT1A
TA polymorphism
Amerindians
Parakanã indians
Glucuronosiltransferase
Polimorfismo (genética)
Regiões promotoras, genética
Grupos etnicos
Alelos
Brazil
dc.subject.en.pt_BR.fl_str_mv Gilbert syndrome
UGT1A
TA polymorphism
Amerindians
Parakanã indians
dc.subject.decs.pt_BR.fl_str_mv Glucuronosiltransferase
Polimorfismo (genética)
Regiões promotoras, genética
Grupos etnicos
Alelos
Brazil
description Marilda de Souza Gonçalves “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2002
dc.date.issued.fl_str_mv 2002
dc.date.accessioned.fl_str_mv 2017-06-09T17:18:52Z
dc.date.available.fl_str_mv 2017-06-09T17:18:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FERTRIN, K. Y. et al. Frequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter polymorphisms among distinct ethnic groups from Brazil. American Journal of Medical Genetics Part A, v. 108, p. 117-119, 2002.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/19359
dc.identifier.issn.pt_BR.fl_str_mv 1552-4825
identifier_str_mv FERTRIN, K. Y. et al. Frequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter polymorphisms among distinct ethnic groups from Brazil. American Journal of Medical Genetics Part A, v. 108, p. 117-119, 2002.
1552-4825
url https://www.arca.fiocruz.br/handle/icict/19359
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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