Evaluation of Alpha-1 Antitrypsin Levels and SERPINA1 Gene Polymorphisms in Sickle Cell Disease

Detalhes bibliográficos
Autor(a) principal: Carvalho, Magda Oliveira Seixas
Data de Publicação: 2017
Outros Autores: Souza, André Luís Carvalho Santos, Carvalho, Mauricio Batista, Pacheco, Ana Paula Almeida Souza, Rocha, Larissa Carneiro, Nascimento, Valma Maria Lopes do, Figueiredo, Camylla Vilas Boas, Guarda, Caroline Conceição, Santiago, Rayra Pereira, Adekile, Adekunle D., Goncalves, Marilda de Souza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/24985
Resumo: Brazilian National Council of Research (CNPq) (311888/2013-5) (MG); the Foundation of Research and Extension of Bahia (FAPESB) (3626/2013, 1431040053063, and 9073/2007) (MG); and PPSUS/ FAPESB (020/2013 EFP_00007295) (MG) and MCD/CNPq/MS-SCTIE-DECIT (409800/2006-6) (MG).
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spelling Carvalho, Magda Oliveira SeixasSouza, André Luís Carvalho SantosCarvalho, Mauricio BatistaPacheco, Ana Paula Almeida SouzaRocha, Larissa CarneiroNascimento, Valma Maria Lopes doFigueiredo, Camylla Vilas BoasGuarda, Caroline ConceiçãoSantiago, Rayra PereiraAdekile, Adekunle D.Goncalves, Marilda de Souza2018-02-27T17:22:46Z2018-02-27T17:22:46Z2017CARVALHO, Magda Oliveira Seixas et al. Evaluation of Alpha-1 Antitrypsin Levels andSERPINA1Gene Polymorphisms in Sickle Cell Disease. Frontiers in Immunology, v. 8, Article 1491, p. 1-11, Nov. 2017.1664-3224https://www.arca.fiocruz.br/handle/icict/2498510.3389/fimmu.2017.01491Brazilian National Council of Research (CNPq) (311888/2013-5) (MG); the Foundation of Research and Extension of Bahia (FAPESB) (3626/2013, 1431040053063, and 9073/2007) (MG); and PPSUS/ FAPESB (020/2013 EFP_00007295) (MG) and MCD/CNPq/MS-SCTIE-DECIT (409800/2006-6) (MG).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação de Hematologia e Hemoterapia da Bahia. Salvador, BA, Brasil.Fundação de Hematologia e Hemoterapia da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Kuwait University. Department of Pediatrics. Kuwait City, Kuwait.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Alpha-1 antitrypsin (AAT) is an inhibitor of neutrophil elastase and a member of the serine proteinase inhibitor (serpin) superfamily, and little is known about its activity in sickle cell disease (SCD). We hypothesize that AAT may undergo changes in SCD because of the high oxidative stress and inflammation associated with the disease. We have found high AAT levels in SCD patients compared to controls, while mutant genotypes ofSERPINA1gene had decreased AAT levels, in both groups. AAT showed negative correlation with red blood cells, hemoglobin (Hb), hematocrit, high-density lipoprotein cholesterol, urea, creatinine, and albumin and was positively correlated with mean corpuscular Hb concentration, white blood cells, neutrophils, Hb S, bilirubin, lactate dehydrogenase, ferritin, and C-reactive protein. Patients with higher levels of AAT had more infection episodes (OR = 1.71, CI: 1.05-2.65,p = 0.02), gallstones (OR = 1.75, CI: 1.03-2.97,p = 0.02), and had more blood transfusions (OR = 2.35, CI: 1.51-3.65,p = 0.0001). Our data on AAT association with laboratory indices of hemolysis and inflammation suggest that it may be positively associated with SCD severity; the negative correlations with renal parameters suggest a cytoprotective mechanism in SCD patients. In summary, AAT may need to be included in studies related to SCD and in the discussion of further therapeutic strategies.engFrontiers MediaDoença FalciformeAlfa-1 antitripsinaSERPINA1BiomarcadoresInflamaçãoSickle Cell DiseaseAlpha-1 antitrypsinSERPINA1BiomarkersInflammationEvaluation of Alpha-1 Antitrypsin Levels and SERPINA1 Gene Polymorphisms in Sickle Cell Diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24985/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCarvalho MO Evaluation of Alpha-1 Antitrypsin Levels ....pdfCarvalho MO Evaluation of Alpha-1 Antitrypsin Levels 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dc.title.pt_BR.fl_str_mv Evaluation of Alpha-1 Antitrypsin Levels and SERPINA1 Gene Polymorphisms in Sickle Cell Disease
title Evaluation of Alpha-1 Antitrypsin Levels and SERPINA1 Gene Polymorphisms in Sickle Cell Disease
spellingShingle Evaluation of Alpha-1 Antitrypsin Levels and SERPINA1 Gene Polymorphisms in Sickle Cell Disease
Carvalho, Magda Oliveira Seixas
Doença Falciforme
Alfa-1 antitripsina
SERPINA1
Biomarcadores
Inflamação
Sickle Cell Disease
Alpha-1 antitrypsin
SERPINA1
Biomarkers
Inflammation
title_short Evaluation of Alpha-1 Antitrypsin Levels and SERPINA1 Gene Polymorphisms in Sickle Cell Disease
title_full Evaluation of Alpha-1 Antitrypsin Levels and SERPINA1 Gene Polymorphisms in Sickle Cell Disease
title_fullStr Evaluation of Alpha-1 Antitrypsin Levels and SERPINA1 Gene Polymorphisms in Sickle Cell Disease
title_full_unstemmed Evaluation of Alpha-1 Antitrypsin Levels and SERPINA1 Gene Polymorphisms in Sickle Cell Disease
title_sort Evaluation of Alpha-1 Antitrypsin Levels and SERPINA1 Gene Polymorphisms in Sickle Cell Disease
author Carvalho, Magda Oliveira Seixas
author_facet Carvalho, Magda Oliveira Seixas
Souza, André Luís Carvalho Santos
Carvalho, Mauricio Batista
Pacheco, Ana Paula Almeida Souza
Rocha, Larissa Carneiro
Nascimento, Valma Maria Lopes do
Figueiredo, Camylla Vilas Boas
Guarda, Caroline Conceição
Santiago, Rayra Pereira
Adekile, Adekunle D.
Goncalves, Marilda de Souza
author_role author
author2 Souza, André Luís Carvalho Santos
Carvalho, Mauricio Batista
Pacheco, Ana Paula Almeida Souza
Rocha, Larissa Carneiro
Nascimento, Valma Maria Lopes do
Figueiredo, Camylla Vilas Boas
Guarda, Caroline Conceição
Santiago, Rayra Pereira
Adekile, Adekunle D.
Goncalves, Marilda de Souza
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho, Magda Oliveira Seixas
Souza, André Luís Carvalho Santos
Carvalho, Mauricio Batista
Pacheco, Ana Paula Almeida Souza
Rocha, Larissa Carneiro
Nascimento, Valma Maria Lopes do
Figueiredo, Camylla Vilas Boas
Guarda, Caroline Conceição
Santiago, Rayra Pereira
Adekile, Adekunle D.
Goncalves, Marilda de Souza
dc.subject.other.pt_BR.fl_str_mv Doença Falciforme
Alfa-1 antitripsina
SERPINA1
Biomarcadores
Inflamação
topic Doença Falciforme
Alfa-1 antitripsina
SERPINA1
Biomarcadores
Inflamação
Sickle Cell Disease
Alpha-1 antitrypsin
SERPINA1
Biomarkers
Inflammation
dc.subject.en.pt_BR.fl_str_mv Sickle Cell Disease
Alpha-1 antitrypsin
SERPINA1
Biomarkers
Inflammation
description Brazilian National Council of Research (CNPq) (311888/2013-5) (MG); the Foundation of Research and Extension of Bahia (FAPESB) (3626/2013, 1431040053063, and 9073/2007) (MG); and PPSUS/ FAPESB (020/2013 EFP_00007295) (MG) and MCD/CNPq/MS-SCTIE-DECIT (409800/2006-6) (MG).
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-02-27T17:22:46Z
dc.date.available.fl_str_mv 2018-02-27T17:22:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARVALHO, Magda Oliveira Seixas et al. Evaluation of Alpha-1 Antitrypsin Levels andSERPINA1Gene Polymorphisms in Sickle Cell Disease. Frontiers in Immunology, v. 8, Article 1491, p. 1-11, Nov. 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/24985
dc.identifier.issn.pt_BR.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2017.01491
identifier_str_mv CARVALHO, Magda Oliveira Seixas et al. Evaluation of Alpha-1 Antitrypsin Levels andSERPINA1Gene Polymorphisms in Sickle Cell Disease. Frontiers in Immunology, v. 8, Article 1491, p. 1-11, Nov. 2017.
1664-3224
10.3389/fimmu.2017.01491
url https://www.arca.fiocruz.br/handle/icict/24985
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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