Evaluation of Alpha-1 Antitrypsin Levels and SERPINA1 Gene Polymorphisms in Sickle Cell Disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/24985 |
Resumo: | Brazilian National Council of Research (CNPq) (311888/2013-5) (MG); the Foundation of Research and Extension of Bahia (FAPESB) (3626/2013, 1431040053063, and 9073/2007) (MG); and PPSUS/ FAPESB (020/2013 EFP_00007295) (MG) and MCD/CNPq/MS-SCTIE-DECIT (409800/2006-6) (MG). |
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Carvalho, Magda Oliveira SeixasSouza, André Luís Carvalho SantosCarvalho, Mauricio BatistaPacheco, Ana Paula Almeida SouzaRocha, Larissa CarneiroNascimento, Valma Maria Lopes doFigueiredo, Camylla Vilas BoasGuarda, Caroline ConceiçãoSantiago, Rayra PereiraAdekile, Adekunle D.Goncalves, Marilda de Souza2018-02-27T17:22:46Z2018-02-27T17:22:46Z2017CARVALHO, Magda Oliveira Seixas et al. Evaluation of Alpha-1 Antitrypsin Levels andSERPINA1Gene Polymorphisms in Sickle Cell Disease. Frontiers in Immunology, v. 8, Article 1491, p. 1-11, Nov. 2017.1664-3224https://www.arca.fiocruz.br/handle/icict/2498510.3389/fimmu.2017.01491Brazilian National Council of Research (CNPq) (311888/2013-5) (MG); the Foundation of Research and Extension of Bahia (FAPESB) (3626/2013, 1431040053063, and 9073/2007) (MG); and PPSUS/ FAPESB (020/2013 EFP_00007295) (MG) and MCD/CNPq/MS-SCTIE-DECIT (409800/2006-6) (MG).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Complexo Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação de Hematologia e Hemoterapia da Bahia. Salvador, BA, Brasil.Fundação de Hematologia e Hemoterapia da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Kuwait University. Department of Pediatrics. Kuwait City, Kuwait.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Alpha-1 antitrypsin (AAT) is an inhibitor of neutrophil elastase and a member of the serine proteinase inhibitor (serpin) superfamily, and little is known about its activity in sickle cell disease (SCD). We hypothesize that AAT may undergo changes in SCD because of the high oxidative stress and inflammation associated with the disease. We have found high AAT levels in SCD patients compared to controls, while mutant genotypes ofSERPINA1gene had decreased AAT levels, in both groups. AAT showed negative correlation with red blood cells, hemoglobin (Hb), hematocrit, high-density lipoprotein cholesterol, urea, creatinine, and albumin and was positively correlated with mean corpuscular Hb concentration, white blood cells, neutrophils, Hb S, bilirubin, lactate dehydrogenase, ferritin, and C-reactive protein. Patients with higher levels of AAT had more infection episodes (OR = 1.71, CI: 1.05-2.65,p = 0.02), gallstones (OR = 1.75, CI: 1.03-2.97,p = 0.02), and had more blood transfusions (OR = 2.35, CI: 1.51-3.65,p = 0.0001). Our data on AAT association with laboratory indices of hemolysis and inflammation suggest that it may be positively associated with SCD severity; the negative correlations with renal parameters suggest a cytoprotective mechanism in SCD patients. In summary, AAT may need to be included in studies related to SCD and in the discussion of further therapeutic strategies.engFrontiers MediaDoença FalciformeAlfa-1 antitripsinaSERPINA1BiomarcadoresInflamaçãoSickle Cell DiseaseAlpha-1 antitrypsinSERPINA1BiomarkersInflammationEvaluation of Alpha-1 Antitrypsin Levels and SERPINA1 Gene Polymorphisms in Sickle Cell Diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24985/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCarvalho MO Evaluation of Alpha-1 Antitrypsin Levels ....pdfCarvalho MO Evaluation of Alpha-1 Antitrypsin Levels 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| dc.title.pt_BR.fl_str_mv |
Evaluation of Alpha-1 Antitrypsin Levels and SERPINA1 Gene Polymorphisms in Sickle Cell Disease |
| title |
Evaluation of Alpha-1 Antitrypsin Levels and SERPINA1 Gene Polymorphisms in Sickle Cell Disease |
| spellingShingle |
Evaluation of Alpha-1 Antitrypsin Levels and SERPINA1 Gene Polymorphisms in Sickle Cell Disease Carvalho, Magda Oliveira Seixas Doença Falciforme Alfa-1 antitripsina SERPINA1 Biomarcadores Inflamação Sickle Cell Disease Alpha-1 antitrypsin SERPINA1 Biomarkers Inflammation |
| title_short |
Evaluation of Alpha-1 Antitrypsin Levels and SERPINA1 Gene Polymorphisms in Sickle Cell Disease |
| title_full |
Evaluation of Alpha-1 Antitrypsin Levels and SERPINA1 Gene Polymorphisms in Sickle Cell Disease |
| title_fullStr |
Evaluation of Alpha-1 Antitrypsin Levels and SERPINA1 Gene Polymorphisms in Sickle Cell Disease |
| title_full_unstemmed |
Evaluation of Alpha-1 Antitrypsin Levels and SERPINA1 Gene Polymorphisms in Sickle Cell Disease |
| title_sort |
Evaluation of Alpha-1 Antitrypsin Levels and SERPINA1 Gene Polymorphisms in Sickle Cell Disease |
| author |
Carvalho, Magda Oliveira Seixas |
| author_facet |
Carvalho, Magda Oliveira Seixas Souza, André Luís Carvalho Santos Carvalho, Mauricio Batista Pacheco, Ana Paula Almeida Souza Rocha, Larissa Carneiro Nascimento, Valma Maria Lopes do Figueiredo, Camylla Vilas Boas Guarda, Caroline Conceição Santiago, Rayra Pereira Adekile, Adekunle D. Goncalves, Marilda de Souza |
| author_role |
author |
| author2 |
Souza, André Luís Carvalho Santos Carvalho, Mauricio Batista Pacheco, Ana Paula Almeida Souza Rocha, Larissa Carneiro Nascimento, Valma Maria Lopes do Figueiredo, Camylla Vilas Boas Guarda, Caroline Conceição Santiago, Rayra Pereira Adekile, Adekunle D. Goncalves, Marilda de Souza |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Carvalho, Magda Oliveira Seixas Souza, André Luís Carvalho Santos Carvalho, Mauricio Batista Pacheco, Ana Paula Almeida Souza Rocha, Larissa Carneiro Nascimento, Valma Maria Lopes do Figueiredo, Camylla Vilas Boas Guarda, Caroline Conceição Santiago, Rayra Pereira Adekile, Adekunle D. Goncalves, Marilda de Souza |
| dc.subject.other.pt_BR.fl_str_mv |
Doença Falciforme Alfa-1 antitripsina SERPINA1 Biomarcadores Inflamação |
| topic |
Doença Falciforme Alfa-1 antitripsina SERPINA1 Biomarcadores Inflamação Sickle Cell Disease Alpha-1 antitrypsin SERPINA1 Biomarkers Inflammation |
| dc.subject.en.pt_BR.fl_str_mv |
Sickle Cell Disease Alpha-1 antitrypsin SERPINA1 Biomarkers Inflammation |
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Brazilian National Council of Research (CNPq) (311888/2013-5) (MG); the Foundation of Research and Extension of Bahia (FAPESB) (3626/2013, 1431040053063, and 9073/2007) (MG); and PPSUS/ FAPESB (020/2013 EFP_00007295) (MG) and MCD/CNPq/MS-SCTIE-DECIT (409800/2006-6) (MG). |
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2017 |
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2017 |
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2018-02-27T17:22:46Z |
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2018-02-27T17:22:46Z |
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CARVALHO, Magda Oliveira Seixas et al. Evaluation of Alpha-1 Antitrypsin Levels andSERPINA1Gene Polymorphisms in Sickle Cell Disease. Frontiers in Immunology, v. 8, Article 1491, p. 1-11, Nov. 2017. |
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https://www.arca.fiocruz.br/handle/icict/24985 |
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1664-3224 |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fimmu.2017.01491 |
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CARVALHO, Magda Oliveira Seixas et al. Evaluation of Alpha-1 Antitrypsin Levels andSERPINA1Gene Polymorphisms in Sickle Cell Disease. Frontiers in Immunology, v. 8, Article 1491, p. 1-11, Nov. 2017. 1664-3224 10.3389/fimmu.2017.01491 |
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Frontiers Media |
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Frontiers Media |
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