Neurological Manifestations in Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)-Infected Individuals Without HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Longitudinal Cohort Study.

Detalhes bibliográficos
Autor(a) principal: Tanajura, Davi
Data de Publicação: 2015
Outros Autores: Castro, Néviton, Santos, Paulo Oliveira dos, Neto, Abraão, Santos, André Luiz Muniz Alves dos, Carvalho, Natália B, Orge, Glória, Santos, Silvane Maria Braga, Glesby, Marshall J, Carvalho Filho, Edgar Marcelino
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13739
Resumo: Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / National Institute of Science and Technology of Tropical Diseases. Salvador, BA, Brasil / State University of Bahia. Department of Natural Sciences, Southeast. Vitória da Conquista, BA, Brasil
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spelling Tanajura, DaviCastro, NévitonSantos, Paulo Oliveira dosNeto, AbraãoSantos, André Luiz Muniz Alves dosCarvalho, Natália BOrge, GlóriaSantos, Silvane Maria BragaGlesby, Marshall JCarvalho Filho, Edgar Marcelino2016-04-12T19:32:48Z2016-04-12T19:32:48Z2015TANAJURA, D. et al. Neurological Manifestations in Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)-Infected Individuals Without HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Longitudinal Cohort Study. Clinical of Infectious Diseases, v. 61, n. 1, p. 49-56, 2015.1537-6591https://www.arca.fiocruz.br/handle/icict/1373910.1093/cid/civ229engUniversity of Chicago PressNeurological Manifestations in Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)-Infected Individuals Without HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Longitudinal Cohort Study.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / National Institute of Science and Technology of Tropical Diseases. Salvador, BA, Brasil / State University of Bahia. Department of Natural Sciences, Southeast. Vitória da Conquista, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / National Institute of Science and Technology of Tropical Diseases. Salvador, BA, Brasil / State University of Feira de Santana. Department of Biological Sciences. Faira de Santana, BA, BrasilWeill Cornell Medical College. Department of Medicine. New York, New YorkUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / National Institute of Science and Technology of Tropical Diseases. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Ba, BrasilBACKGROUND: Human T-cell lymphotropic virus type 1 (HTLV-1) is the agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), observed in up to 5% of infected individuals. Despite low prevalence, many HTLV-1-infected patients who do not fulfill criteria for HAM/TSP present with neurological complaints related to sensory, motor, urinary, or autonomic manifestations. The aim of this study was to determine the incidence of neurologic manifestations and risk factors associated with these outcomes. METHODS: The incidence of HAM/TSP and new signs and neurologic symptoms were computed in a group of patients enrolled in a cohort study. RESULTS: Of 414 subjects, 76 had definite HAM/TSP, 87 had possible or probable HAM/TSP, and 251 subjects had no neurologic manifestation and were selected for analysis. Definite HAM/TSP developed in 5 (1.47%) patients. Follow-up of at least 3 years was achieved in 51% of patients. The incidence rate was computed in 1000 person-years (206 for hand numbness, 187 for feet numbness, 130 for nocturia, and 127 for urgency). Average incidence rate in neurological exam was 76 for leg hyperreflexia, 53 for leg weakness, and 37 for Babinski sign. In the applied Expanded Disability Status Scale, the incidence rate of worsening 1 point was 134 per 1000 person-years. Kaplan-Meier curves stratified by sex and proviral load showed that females and patients with proviral load >50,000 copies/10(6) peripheral blood mononuclear cells had a higher risk of progression. CONCLUSIONS: Development of neurological symptoms or signs occurred in up to 30% of asymptomatic subjects during 8 years of follow-up.HTLV-1HAM/TSPNeurologic manifestationsCohortIncidenceInfecções por HTLV-I/complicaçõesDoenças do Sistema Nervoso/epidemiologiaDoenças do Sistema Nervoso/patologiaAdultoIdosoFemininoHumanosIncidênciaEstudos LongitudinaisMasculinoMeia-IdadeFatores de Riscoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13739/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALTanajura D Neurological manifestations....pdfTanajura D Neurological manifestations....pdfapplication/pdf241499https://www.arca.fiocruz.br/bitstream/icict/13739/2/Tanajura%20D%20Neurological%20manifestations....pdf14df94e3e9b8ce05a3ef2c182ba9615fMD52TEXTTanajura D Neurological 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dc.title.pt_BR.fl_str_mv Neurological Manifestations in Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)-Infected Individuals Without HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Longitudinal Cohort Study.
title Neurological Manifestations in Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)-Infected Individuals Without HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Longitudinal Cohort Study.
spellingShingle Neurological Manifestations in Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)-Infected Individuals Without HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Longitudinal Cohort Study.
Tanajura, Davi
HTLV-1
HAM/TSP
Neurologic manifestations
Cohort
Incidence
Infecções por HTLV-I/complicações
Doenças do Sistema Nervoso/epidemiologia
Doenças do Sistema Nervoso/patologia
Adulto
Idoso
Feminino
Humanos
Incidência
Estudos Longitudinais
Masculino
Meia-Idade
Fatores de Risco
title_short Neurological Manifestations in Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)-Infected Individuals Without HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Longitudinal Cohort Study.
title_full Neurological Manifestations in Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)-Infected Individuals Without HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Longitudinal Cohort Study.
title_fullStr Neurological Manifestations in Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)-Infected Individuals Without HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Longitudinal Cohort Study.
title_full_unstemmed Neurological Manifestations in Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)-Infected Individuals Without HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Longitudinal Cohort Study.
title_sort Neurological Manifestations in Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)-Infected Individuals Without HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Longitudinal Cohort Study.
author Tanajura, Davi
author_facet Tanajura, Davi
Castro, Néviton
Santos, Paulo Oliveira dos
Neto, Abraão
Santos, André Luiz Muniz Alves dos
Carvalho, Natália B
Orge, Glória
Santos, Silvane Maria Braga
Glesby, Marshall J
Carvalho Filho, Edgar Marcelino
author_role author
author2 Castro, Néviton
Santos, Paulo Oliveira dos
Neto, Abraão
Santos, André Luiz Muniz Alves dos
Carvalho, Natália B
Orge, Glória
Santos, Silvane Maria Braga
Glesby, Marshall J
Carvalho Filho, Edgar Marcelino
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Tanajura, Davi
Castro, Néviton
Santos, Paulo Oliveira dos
Neto, Abraão
Santos, André Luiz Muniz Alves dos
Carvalho, Natália B
Orge, Glória
Santos, Silvane Maria Braga
Glesby, Marshall J
Carvalho Filho, Edgar Marcelino
dc.subject.en.pt_BR.fl_str_mv HTLV-1
HAM/TSP
Neurologic manifestations
Cohort
Incidence
topic HTLV-1
HAM/TSP
Neurologic manifestations
Cohort
Incidence
Infecções por HTLV-I/complicações
Doenças do Sistema Nervoso/epidemiologia
Doenças do Sistema Nervoso/patologia
Adulto
Idoso
Feminino
Humanos
Incidência
Estudos Longitudinais
Masculino
Meia-Idade
Fatores de Risco
dc.subject.decs.pt_BR.fl_str_mv Infecções por HTLV-I/complicações
Doenças do Sistema Nervoso/epidemiologia
Doenças do Sistema Nervoso/patologia
Adulto
Idoso
Feminino
Humanos
Incidência
Estudos Longitudinais
Masculino
Meia-Idade
Fatores de Risco
description Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / National Institute of Science and Technology of Tropical Diseases. Salvador, BA, Brasil / State University of Bahia. Department of Natural Sciences, Southeast. Vitória da Conquista, BA, Brasil
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-04-12T19:32:48Z
dc.date.available.fl_str_mv 2016-04-12T19:32:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TANAJURA, D. et al. Neurological Manifestations in Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)-Infected Individuals Without HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Longitudinal Cohort Study. Clinical of Infectious Diseases, v. 61, n. 1, p. 49-56, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13739
dc.identifier.issn.none.fl_str_mv 1537-6591
dc.identifier.doi.none.fl_str_mv 10.1093/cid/civ229
identifier_str_mv TANAJURA, D. et al. Neurological Manifestations in Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)-Infected Individuals Without HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Longitudinal Cohort Study. Clinical of Infectious Diseases, v. 61, n. 1, p. 49-56, 2015.
1537-6591
10.1093/cid/civ229
url https://www.arca.fiocruz.br/handle/icict/13739
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv University of Chicago Press
publisher.none.fl_str_mv University of Chicago Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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