Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity

Detalhes bibliográficos
Autor(a) principal: Costa, Gustavo Nunes de Oliveira
Data de Publicação: 2019
Outros Autores: Figueiredo, Camila Alexandrina, Conceição, Jackson Santos, Strina, Agostino, Genser, Bernd, Silva, Thiago Magalhaes da, Neves, Neuza Maria Alcantara, Fiaccone, Rosemeire Leovigildo, Rodrigues, Laura Cunha, Barreto, Mauricio Lima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36304
Resumo: Department of Science and Technology (DECIT, Ministry of Health), National Fund for Scientific and Technological Development (FNDCT, Ministry of Science and Technology), Funding of Studies and Projects (FINEP, Ministry of Science and Technology, Brazil) and the Brazilian National Research Council (CNPq).
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spelling Costa, Gustavo Nunes de OliveiraFigueiredo, Camila AlexandrinaConceição, Jackson SantosStrina, AgostinoGenser, BerndSilva, Thiago Magalhaes daNeves, Neuza Maria AlcantaraFiaccone, Rosemeire LeovigildoRodrigues, Laura CunhaBarreto, Mauricio Lima2019-10-09T17:03:24Z2019-10-09T17:03:24Z2019COSTA, Gustavo Nunes de Oliveira et al. Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity. Gene, v. 715, p. 1-7, 2019.0378-1119https://www.arca.fiocruz.br/handle/icict/3630410.1016/j.gene.2019.143991Department of Science and Technology (DECIT, Ministry of Health), National Fund for Scientific and Technological Development (FNDCT, Ministry of Science and Technology), Funding of Studies and Projects (FINEP, Ministry of Science and Technology, Brazil) and the Brazilian National Research Council (CNPq).2020-01-08Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Universidade Salvador. Departamento de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.University of Heidelberg. Medical Faculty Mannheim. Mannheim Institute of Public Health, Social and Preventive Medicine. Mannheim, Germany.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil.London School of Hygiene and Tropical Medicine. Department of Epidemiology and Populations Health. UKFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Asthma is a complex disease with worldwide public health relevance, is related to environmental causes and a genetic predisposition. The chromosomal 17q12-21 locus has been consistently demonstrated to be associated with asthma risk. The effects of variants in the 17q12-21 locus on childhood asthma were first identified in a genome wide- association study. Since that time, those findings have been replicated in different populations but not in South American populations. Objective: This study aimed to investigate the role of variants in the 17q12-21 locus on asthma in a sample of Brazilian children. Methods: This was a cross-sectional study conducted on a cohort of 1247 children. These analyses used 50 Single Nucleotide Variants (SNVs) in the 17q12-21 locus were genotyped as part of a genome wide association study (GWAS). Results: Four SNVs (rs4065275, rs12603332, rs73985228 and rs77777702) were associated with childhood asthma. The rs73985228 exhibited the strongest association across the different genetic models (OR, 95%CI 2.8, 1.44–3.21, p < 0.01). In an analysis that was stratified by atopy, two SNVs (rs73985228 and rs2715555) were found to be associated with atopic and non-atopic asthma. For the first time, we observed a significant interaction with seropositivity for the Varicella zoster virus (for rs4065275, p=0.02, and for rs12603332, p=0.04); i.e., the association was found in those who were seropositive but not in those who were seronegative for this virus. Conclusions: We confirmed the associations of variants in the 17q12-21 locus with atopic and non-atopic asthma and identified an interaction with seropositivity for the Varicella zoster virus.engElsevierAsma infantilAtopiaVaricella zosterPredisposição Genética para DoençaHumanosChildhood asthmaAtopyVaricella zosterGenetic Predisposition to DiseaseHumansGenetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/36304/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCosta Gustavo Nunes Oliveira Genetic...pdfCosta Gustavo Nunes Oliveira 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dc.title.pt_BR.fl_str_mv Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity
title Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity
spellingShingle Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity
Costa, Gustavo Nunes de Oliveira
Asma infantil
Atopia
Varicella zoster
Predisposição Genética para Doença
Humanos
Childhood asthma
Atopy
Varicella zoster
Genetic Predisposition to Disease
Humans
title_short Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity
title_full Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity
title_fullStr Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity
title_full_unstemmed Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity
title_sort Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity
author Costa, Gustavo Nunes de Oliveira
author_facet Costa, Gustavo Nunes de Oliveira
Figueiredo, Camila Alexandrina
Conceição, Jackson Santos
Strina, Agostino
Genser, Bernd
Silva, Thiago Magalhaes da
Neves, Neuza Maria Alcantara
Fiaccone, Rosemeire Leovigildo
Rodrigues, Laura Cunha
Barreto, Mauricio Lima
author_role author
author2 Figueiredo, Camila Alexandrina
Conceição, Jackson Santos
Strina, Agostino
Genser, Bernd
Silva, Thiago Magalhaes da
Neves, Neuza Maria Alcantara
Fiaccone, Rosemeire Leovigildo
Rodrigues, Laura Cunha
Barreto, Mauricio Lima
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Costa, Gustavo Nunes de Oliveira
Figueiredo, Camila Alexandrina
Conceição, Jackson Santos
Strina, Agostino
Genser, Bernd
Silva, Thiago Magalhaes da
Neves, Neuza Maria Alcantara
Fiaccone, Rosemeire Leovigildo
Rodrigues, Laura Cunha
Barreto, Mauricio Lima
dc.subject.other.pt_BR.fl_str_mv Asma infantil
Atopia
Varicella zoster
Predisposição Genética para Doença
Humanos
topic Asma infantil
Atopia
Varicella zoster
Predisposição Genética para Doença
Humanos
Childhood asthma
Atopy
Varicella zoster
Genetic Predisposition to Disease
Humans
dc.subject.en.pt_BR.fl_str_mv Childhood asthma
Atopy
Varicella zoster
Genetic Predisposition to Disease
Humans
description Department of Science and Technology (DECIT, Ministry of Health), National Fund for Scientific and Technological Development (FNDCT, Ministry of Science and Technology), Funding of Studies and Projects (FINEP, Ministry of Science and Technology, Brazil) and the Brazilian National Research Council (CNPq).
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-10-09T17:03:24Z
dc.date.available.fl_str_mv 2019-10-09T17:03:24Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv COSTA, Gustavo Nunes de Oliveira et al. Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity. Gene, v. 715, p. 1-7, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36304
dc.identifier.issn.pt_BR.fl_str_mv 0378-1119
dc.identifier.doi.none.fl_str_mv 10.1016/j.gene.2019.143991
identifier_str_mv COSTA, Gustavo Nunes de Oliveira et al. Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity. Gene, v. 715, p. 1-7, 2019.
0378-1119
10.1016/j.gene.2019.143991
url https://www.arca.fiocruz.br/handle/icict/36304
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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