Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/36304 |
Resumo: | Department of Science and Technology (DECIT, Ministry of Health), National Fund for Scientific and Technological Development (FNDCT, Ministry of Science and Technology), Funding of Studies and Projects (FINEP, Ministry of Science and Technology, Brazil) and the Brazilian National Research Council (CNPq). |
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Costa, Gustavo Nunes de OliveiraFigueiredo, Camila AlexandrinaConceição, Jackson SantosStrina, AgostinoGenser, BerndSilva, Thiago Magalhaes daNeves, Neuza Maria AlcantaraFiaccone, Rosemeire LeovigildoRodrigues, Laura CunhaBarreto, Mauricio Lima2019-10-09T17:03:24Z2019-10-09T17:03:24Z2019COSTA, Gustavo Nunes de Oliveira et al. Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity. Gene, v. 715, p. 1-7, 2019.0378-1119https://www.arca.fiocruz.br/handle/icict/3630410.1016/j.gene.2019.143991Department of Science and Technology (DECIT, Ministry of Health), National Fund for Scientific and Technological Development (FNDCT, Ministry of Science and Technology), Funding of Studies and Projects (FINEP, Ministry of Science and Technology, Brazil) and the Brazilian National Research Council (CNPq).2020-01-08Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Universidade Salvador. Departamento de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.University of Heidelberg. Medical Faculty Mannheim. Mannheim Institute of Public Health, Social and Preventive Medicine. Mannheim, Germany.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil.London School of Hygiene and Tropical Medicine. Department of Epidemiology and Populations Health. UKFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Asthma is a complex disease with worldwide public health relevance, is related to environmental causes and a genetic predisposition. The chromosomal 17q12-21 locus has been consistently demonstrated to be associated with asthma risk. The effects of variants in the 17q12-21 locus on childhood asthma were first identified in a genome wide- association study. Since that time, those findings have been replicated in different populations but not in South American populations. Objective: This study aimed to investigate the role of variants in the 17q12-21 locus on asthma in a sample of Brazilian children. Methods: This was a cross-sectional study conducted on a cohort of 1247 children. These analyses used 50 Single Nucleotide Variants (SNVs) in the 17q12-21 locus were genotyped as part of a genome wide association study (GWAS). Results: Four SNVs (rs4065275, rs12603332, rs73985228 and rs77777702) were associated with childhood asthma. The rs73985228 exhibited the strongest association across the different genetic models (OR, 95%CI 2.8, 1.44–3.21, p < 0.01). In an analysis that was stratified by atopy, two SNVs (rs73985228 and rs2715555) were found to be associated with atopic and non-atopic asthma. For the first time, we observed a significant interaction with seropositivity for the Varicella zoster virus (for rs4065275, p=0.02, and for rs12603332, p=0.04); i.e., the association was found in those who were seropositive but not in those who were seronegative for this virus. Conclusions: We confirmed the associations of variants in the 17q12-21 locus with atopic and non-atopic asthma and identified an interaction with seropositivity for the Varicella zoster virus.engElsevierAsma infantilAtopiaVaricella zosterPredisposição Genética para DoençaHumanosChildhood asthmaAtopyVaricella zosterGenetic Predisposition to DiseaseHumansGenetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/36304/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCosta Gustavo Nunes Oliveira Genetic...pdfCosta Gustavo Nunes Oliveira Genetic...pdfapplication/pdf528485https://www.arca.fiocruz.br/bitstream/icict/36304/2/Costa%20Gustavo%20Nunes%20Oliveira%20Genetic...pdf09b4f0d021afa73c261f58a3df0f2c7aMD52TEXTCosta Gustavo Nunes Oliveira Genetic...pdf.txtCosta Gustavo Nunes Oliveira Genetic...pdf.txtExtracted texttext/plain45706https://www.arca.fiocruz.br/bitstream/icict/36304/3/Costa%20Gustavo%20Nunes%20Oliveira%20Genetic...pdf.txt97746a76eea92988790f85d2ffb08ad6MD53icict/363042023-03-15 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dc.title.pt_BR.fl_str_mv |
Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity |
title |
Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity |
spellingShingle |
Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity Costa, Gustavo Nunes de Oliveira Asma infantil Atopia Varicella zoster Predisposição Genética para Doença Humanos Childhood asthma Atopy Varicella zoster Genetic Predisposition to Disease Humans |
title_short |
Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity |
title_full |
Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity |
title_fullStr |
Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity |
title_full_unstemmed |
Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity |
title_sort |
Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity |
author |
Costa, Gustavo Nunes de Oliveira |
author_facet |
Costa, Gustavo Nunes de Oliveira Figueiredo, Camila Alexandrina Conceição, Jackson Santos Strina, Agostino Genser, Bernd Silva, Thiago Magalhaes da Neves, Neuza Maria Alcantara Fiaccone, Rosemeire Leovigildo Rodrigues, Laura Cunha Barreto, Mauricio Lima |
author_role |
author |
author2 |
Figueiredo, Camila Alexandrina Conceição, Jackson Santos Strina, Agostino Genser, Bernd Silva, Thiago Magalhaes da Neves, Neuza Maria Alcantara Fiaccone, Rosemeire Leovigildo Rodrigues, Laura Cunha Barreto, Mauricio Lima |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Costa, Gustavo Nunes de Oliveira Figueiredo, Camila Alexandrina Conceição, Jackson Santos Strina, Agostino Genser, Bernd Silva, Thiago Magalhaes da Neves, Neuza Maria Alcantara Fiaccone, Rosemeire Leovigildo Rodrigues, Laura Cunha Barreto, Mauricio Lima |
dc.subject.other.pt_BR.fl_str_mv |
Asma infantil Atopia Varicella zoster Predisposição Genética para Doença Humanos |
topic |
Asma infantil Atopia Varicella zoster Predisposição Genética para Doença Humanos Childhood asthma Atopy Varicella zoster Genetic Predisposition to Disease Humans |
dc.subject.en.pt_BR.fl_str_mv |
Childhood asthma Atopy Varicella zoster Genetic Predisposition to Disease Humans |
description |
Department of Science and Technology (DECIT, Ministry of Health), National Fund for Scientific and Technological Development (FNDCT, Ministry of Science and Technology), Funding of Studies and Projects (FINEP, Ministry of Science and Technology, Brazil) and the Brazilian National Research Council (CNPq). |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-10-09T17:03:24Z |
dc.date.available.fl_str_mv |
2019-10-09T17:03:24Z |
dc.date.issued.fl_str_mv |
2019 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
COSTA, Gustavo Nunes de Oliveira et al. Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity. Gene, v. 715, p. 1-7, 2019. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/36304 |
dc.identifier.issn.pt_BR.fl_str_mv |
0378-1119 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.gene.2019.143991 |
identifier_str_mv |
COSTA, Gustavo Nunes de Oliveira et al. Genetic variants in 17q12-21 locus and childhood asthma in Brazil: Interaction with Varicella zoster virus seropositivity. Gene, v. 715, p. 1-7, 2019. 0378-1119 10.1016/j.gene.2019.143991 |
url |
https://www.arca.fiocruz.br/handle/icict/36304 |
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eng |
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eng |
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Elsevier |
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Elsevier |
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