Correlation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patients.
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/12956 |
Resumo: | Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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Bessa, Theolis Costa BarbosaArruda, Sérgio MarcosChalhoub, MarceloOliveira, FabianoMelo Junior, José FFidelis, RamonN Neto, AntônioBarbosa Junior, Aryon de AlmeidaBarral Netto, Manoel2016-03-03T14:18:28Z2016-03-03T14:18:28Z2006BARBOSA, T. C. et al. Correlation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patients. Microbes and Infection, v. 8, p. 889-897, 2006.1286-4579https://www.arca.fiocruz.br/handle/icict/1295610.1016/j.micinf.2005.10.017engElsevierCorrelation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patients.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Baiana para o Desenvolvimento das Ciências. Salvador, BA, BrasilFundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina.. Salvador, BA, BrasilFundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilFundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina.. Salvador, BA, BrasilIn order to identify mediators involved in immune-mediated disease regression, the pleural cytokine and histopathological profile was evaluated in tuberculous pleurisy patients with varied disease duration and clinical presentation, previous to chemotherapy. Interleukin (IL)-10, interferon (IFN)-g and tumor necrosis factor (TNF) levels in pleural fluids were shown to decrease with disease time. IL-10 was positively correlated with IFN-g, TNF and necrosis area in pleural sections. To parallel these findings with disease regression, individuals showing fever, anorexia, and progressive exudate in the pleural cavity (active disease) were compared with patients without symptoms and with a decrease in exudate volume (regressive disease). IFN-g and TNF levels were lower in regressive disease, as well as reduced necrosis area in pleural sections. Our results indicate that tissue destruction and a prominent Th1 response mark the early phase of tuberculous pleurisy and suggest that downmodulation of this response, with the possible participation of IL-10, is associated with disease resolutionTuberculosisPleuralDisease progressionCytokinesPathologyFibrose/metabolismoInterleucina-10/metabolismoNecrose/metabolismoTuberculose Pleural/metabolismoAdolescenteAdultoIdosoProgressão da DoençaFemininoHumanoMasculinoMeia-Idadeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12956/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBarbosa T Correlation between....pdfBarbosa T Correlation 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dc.title.pt_BR.fl_str_mv |
Correlation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patients. |
title |
Correlation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patients. |
spellingShingle |
Correlation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patients. Bessa, Theolis Costa Barbosa Tuberculosis Pleural Disease progression Cytokines Pathology Fibrose/metabolismo Interleucina-10/metabolismo Necrose/metabolismo Tuberculose Pleural/metabolismo Adolescente Adulto Idoso Progressão da Doença Feminino Humano Masculino Meia-Idade |
title_short |
Correlation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patients. |
title_full |
Correlation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patients. |
title_fullStr |
Correlation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patients. |
title_full_unstemmed |
Correlation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patients. |
title_sort |
Correlation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patients. |
author |
Bessa, Theolis Costa Barbosa |
author_facet |
Bessa, Theolis Costa Barbosa Arruda, Sérgio Marcos Chalhoub, Marcelo Oliveira, Fabiano Melo Junior, José F Fidelis, Ramon N Neto, Antônio Barbosa Junior, Aryon de Almeida Barral Netto, Manoel |
author_role |
author |
author2 |
Arruda, Sérgio Marcos Chalhoub, Marcelo Oliveira, Fabiano Melo Junior, José F Fidelis, Ramon N Neto, Antônio Barbosa Junior, Aryon de Almeida Barral Netto, Manoel |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Bessa, Theolis Costa Barbosa Arruda, Sérgio Marcos Chalhoub, Marcelo Oliveira, Fabiano Melo Junior, José F Fidelis, Ramon N Neto, Antônio Barbosa Junior, Aryon de Almeida Barral Netto, Manoel |
dc.subject.en.pt_BR.fl_str_mv |
Tuberculosis Pleural Disease progression Cytokines Pathology |
topic |
Tuberculosis Pleural Disease progression Cytokines Pathology Fibrose/metabolismo Interleucina-10/metabolismo Necrose/metabolismo Tuberculose Pleural/metabolismo Adolescente Adulto Idoso Progressão da Doença Feminino Humano Masculino Meia-Idade |
dc.subject.decs.pt_BR.fl_str_mv |
Fibrose/metabolismo Interleucina-10/metabolismo Necrose/metabolismo Tuberculose Pleural/metabolismo Adolescente Adulto Idoso Progressão da Doença Feminino Humano Masculino Meia-Idade |
description |
Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
publishDate |
2006 |
dc.date.issued.fl_str_mv |
2006 |
dc.date.accessioned.fl_str_mv |
2016-03-03T14:18:28Z |
dc.date.available.fl_str_mv |
2016-03-03T14:18:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BARBOSA, T. C. et al. Correlation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patients. Microbes and Infection, v. 8, p. 889-897, 2006. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/12956 |
dc.identifier.issn.none.fl_str_mv |
1286-4579 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.micinf.2005.10.017 |
identifier_str_mv |
BARBOSA, T. C. et al. Correlation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patients. Microbes and Infection, v. 8, p. 889-897, 2006. 1286-4579 10.1016/j.micinf.2005.10.017 |
url |
https://www.arca.fiocruz.br/handle/icict/12956 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Elsevier |
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Elsevier |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) |
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