Correlation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patients
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2006 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/13408 |
Resumo: | Texto completo: acesso restrito. p.889–897 |
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Oliveira, FabianoMelo Junior, José F.Fidelis, RamonN. Neto, AntônioBarral-Netto, ManoelBarbosa Júnior, Aryon de AlmeidaBarbosa, TheolisArruda, Sérgio MarcosChalhoub, MarceloOliveira, FabianoMelo Junior, José F.Fidelis, RamonN. Neto, AntônioBarral-Netto, ManoelBarbosa Júnior, Aryon de AlmeidaBarbosa, TheolisArruda, Sérgio MarcosChalhoub, Marcelo2013-10-31T17:48:27Z20061286-4579http://repositorio.ufba.br/ri/handle/ri/13408v8 n. 3Texto completo: acesso restrito. p.889–897In order to identify mediators involved in immune-mediated disease regression, the pleural cytokine and histopathological profile was evaluated in tuberculous pleurisy patients with varied disease duration and clinical presentation, previous to chemotherapy. Interleukin (IL)-10, interferon (IFN)-γ and tumor necrosis factor (TNF) levels in pleural fluids were shown to decrease with disease time. IL-10 was positively correlated with IFN-γ, TNF and necrosis area in pleural sections. To parallel these findings with disease regression, individuals showing fever, anorexia, and progressive exudate in the pleural cavity (active disease) were compared with patients without symptoms and with a decrease in exudate volume (regressive disease). IFN-γ and TNF levels were lower in regressive disease, as well as reduced necrosis area in pleural sections. Our results indicate that tissue destruction and a prominent Th1 response mark the early phase of tuberculous pleurisy and suggest that down-modulation of this response, with the possible participation of IL-10, is associated with disease resolution.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-08-28T14:57:12Z No. of bitstreams: 1 1-s2.0-S1286457905003850-main.pdf: 384972 bytes, checksum: 27e908da6c9d12feb43c5c98c08f8492 (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-10-31T17:48:27Z (GMT) No. of bitstreams: 1 1-s2.0-S1286457905003850-main.pdf: 384972 bytes, checksum: 27e908da6c9d12feb43c5c98c08f8492 (MD5)Made available in DSpace on 2013-10-31T17:48:27Z (GMT). No. of bitstreams: 1 1-s2.0-S1286457905003850-main.pdf: 384972 bytes, checksum: 27e908da6c9d12feb43c5c98c08f8492 (MD5) Previous issue date: 2006http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.micinf.2005.10.017reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBATuberculosisPleuralDisease progressionCytokinesPathologyCorrelation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patientsMicrobes and Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL1-s2.0-S1286457905003850-main.pdf1-s2.0-S1286457905003850-main.pdfapplication/pdf384972https://repositorio.ufba.br/bitstream/ri/13408/1/1-s2.0-S1286457905003850-main.pdf27e908da6c9d12feb43c5c98c08f8492MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/13408/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT1-s2.0-S1286457905003850-main.pdf.txt1-s2.0-S1286457905003850-main.pdf.txtExtracted texttext/plain35771https://repositorio.ufba.br/bitstream/ri/13408/3/1-s2.0-S1286457905003850-main.pdf.txt5ea1a383dea958fec9436c9f9d9feff1MD53ri/134082022-07-05 14:03:01.53oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:01Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Correlation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patients |
| dc.title.alternative.pt_BR.fl_str_mv |
Microbes and Infection |
| title |
Correlation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patients |
| spellingShingle |
Correlation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patients Oliveira, Fabiano Tuberculosis Pleural Disease progression Cytokines Pathology |
| title_short |
Correlation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patients |
| title_full |
Correlation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patients |
| title_fullStr |
Correlation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patients |
| title_full_unstemmed |
Correlation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patients |
| title_sort |
Correlation between interleukin-10 and in situ necrosis and fibrosis suggests a role for interleukin-10 in the resolution of the granulomatous response of tuberculous pleurisy patients |
| author |
Oliveira, Fabiano |
| author_facet |
Oliveira, Fabiano Melo Junior, José F. Fidelis, Ramon N. Neto, Antônio Barral-Netto, Manoel Barbosa Júnior, Aryon de Almeida Barbosa, Theolis Arruda, Sérgio Marcos Chalhoub, Marcelo |
| author_role |
author |
| author2 |
Melo Junior, José F. Fidelis, Ramon N. Neto, Antônio Barral-Netto, Manoel Barbosa Júnior, Aryon de Almeida Barbosa, Theolis Arruda, Sérgio Marcos Chalhoub, Marcelo |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, Fabiano Melo Junior, José F. Fidelis, Ramon N. Neto, Antônio Barral-Netto, Manoel Barbosa Júnior, Aryon de Almeida Barbosa, Theolis Arruda, Sérgio Marcos Chalhoub, Marcelo Oliveira, Fabiano Melo Junior, José F. Fidelis, Ramon N. Neto, Antônio Barral-Netto, Manoel Barbosa Júnior, Aryon de Almeida Barbosa, Theolis Arruda, Sérgio Marcos Chalhoub, Marcelo |
| dc.subject.por.fl_str_mv |
Tuberculosis Pleural Disease progression Cytokines Pathology |
| topic |
Tuberculosis Pleural Disease progression Cytokines Pathology |
| description |
Texto completo: acesso restrito. p.889–897 |
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2006 |
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2006 |
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2013-10-31T17:48:27Z |
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1286-4579 |
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v8 n. 3 |
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