Dependency of B-1 Cells in the Maintenance of Splenic Interleukin-10 Producing Cells and Impairment of Macrophage Resistance in Visceral Leishmaniasis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.3389/fmicb.2017.00978 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/19736 |
Resumo: | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. |
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Arcanjo, Angélica FernandesNico, DirleiCastro, Gabriellen Menezes Migliani deFontes, Yasmin da SilvaSaltarelli, PaulaRicardo, Debora DecoteNunes, Marise P.Pereira, Antônio FerreiraSousa, Clarisa B. Palatnik deLima, Célio G. Freire deMorrot, Alexandre2017-07-06T12:23:27Z2017-07-06T12:23:27Z2017ARCANJO, Angélica Fernandes; et al. Dependency of B-1 Cells in the Maintenance of Splenic Interleukin-10 Producing Cells and Impairment of Macrophage Resistance in Visceral Leishmaniasis. Frontiers in Microbiology, v.8, Article 978, 7p, June 2017.1664-302Xhttps://www.arca.fiocruz.br/handle/icict/1973610.3389/fmicb.2017.00978engFrontiers MediaLieshmaniose visceralLeishmania infantum chagasiRespostas protetoras do hospedeiroB-1 cellsvisceral leishmaniasisLeishmania (L.) infantum chagasiB-1 cellshost protective responsesDependency of B-1 Cells in the Maintenance of Splenic Interleukin-10 Producing Cells and Impairment of Macrophage Resistance in Visceral Leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Seropédica, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Visceral leishmaniasis is a neglected disease caused by Leishmania protozoa parasites transmitted by infected sand fly vectors. This disease represents the second in mortality among tropical infections and is associated to a profound immunosuppression state of the host. The hallmark of this infection-induced host immunodeviation is the characteristic high levels of the regulatory interleukin-10 (IL-10) cytokine. In the present study, we investigated the role of B-1 cells in the maintenance of splenic IL-10 levels that could interfere with resistance to parasite infection. Using an experimental murine infection model with Leishmania (L.) infantum chagasi we demonstrated an improved resistance of B-1 deficient BALB/XID mice to infection. BALB/XID mice developed a reduced splenomegaly with diminished splenic parasite burden and lower levels of IL-10 secretion of purified splenocytes at 30 days post-infection, as compared to BALB/c wild-type control mice. Interestingly, we found that resident peritoneal macrophages isolated from BALB/XID mice were more effective to control the parasite load in comparison to cells isolated from BALB/c wild-type mice. Our findings point to a role of B-1 cells in the host susceptibility to visceral leishmaniasis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19736/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALalexandre_morrot_etal_IOC_2017.pdfalexandre_morrot_etal_IOC_2017.pdfapplication/pdf1634498https://www.arca.fiocruz.br/bitstream/icict/19736/2/alexandre_morrot_etal_IOC_2017.pdf9d9b90d64c736c54be2cf7b32c439271MD52TEXTalexandre_morrot_etal_IOC_2017.pdf.txtalexandre_morrot_etal_IOC_2017.pdf.txtExtracted texttext/plain32261https://www.arca.fiocruz.br/bitstream/icict/19736/3/alexandre_morrot_etal_IOC_2017.pdf.txtd87ef231b35840af13fdc1e7145d7a18MD53icict/197362022-06-24 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| dc.title.pt_BR.fl_str_mv |
Dependency of B-1 Cells in the Maintenance of Splenic Interleukin-10 Producing Cells and Impairment of Macrophage Resistance in Visceral Leishmaniasis |
| title |
Dependency of B-1 Cells in the Maintenance of Splenic Interleukin-10 Producing Cells and Impairment of Macrophage Resistance in Visceral Leishmaniasis |
| spellingShingle |
Dependency of B-1 Cells in the Maintenance of Splenic Interleukin-10 Producing Cells and Impairment of Macrophage Resistance in Visceral Leishmaniasis Arcanjo, Angélica Fernandes Lieshmaniose visceral Leishmania infantum chagasi Respostas protetoras do hospedeiro B-1 cells visceral leishmaniasis Leishmania (L.) infantum chagasi B-1 cells host protective responses |
| title_short |
Dependency of B-1 Cells in the Maintenance of Splenic Interleukin-10 Producing Cells and Impairment of Macrophage Resistance in Visceral Leishmaniasis |
| title_full |
Dependency of B-1 Cells in the Maintenance of Splenic Interleukin-10 Producing Cells and Impairment of Macrophage Resistance in Visceral Leishmaniasis |
| title_fullStr |
Dependency of B-1 Cells in the Maintenance of Splenic Interleukin-10 Producing Cells and Impairment of Macrophage Resistance in Visceral Leishmaniasis |
| title_full_unstemmed |
Dependency of B-1 Cells in the Maintenance of Splenic Interleukin-10 Producing Cells and Impairment of Macrophage Resistance in Visceral Leishmaniasis |
| title_sort |
Dependency of B-1 Cells in the Maintenance of Splenic Interleukin-10 Producing Cells and Impairment of Macrophage Resistance in Visceral Leishmaniasis |
| author |
Arcanjo, Angélica Fernandes |
| author_facet |
Arcanjo, Angélica Fernandes Nico, Dirlei Castro, Gabriellen Menezes Migliani de Fontes, Yasmin da Silva Saltarelli, Paula Ricardo, Debora Decote Nunes, Marise P. Pereira, Antônio Ferreira Sousa, Clarisa B. Palatnik de Lima, Célio G. Freire de Morrot, Alexandre |
| author_role |
author |
| author2 |
Nico, Dirlei Castro, Gabriellen Menezes Migliani de Fontes, Yasmin da Silva Saltarelli, Paula Ricardo, Debora Decote Nunes, Marise P. Pereira, Antônio Ferreira Sousa, Clarisa B. Palatnik de Lima, Célio G. Freire de Morrot, Alexandre |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Arcanjo, Angélica Fernandes Nico, Dirlei Castro, Gabriellen Menezes Migliani de Fontes, Yasmin da Silva Saltarelli, Paula Ricardo, Debora Decote Nunes, Marise P. Pereira, Antônio Ferreira Sousa, Clarisa B. Palatnik de Lima, Célio G. Freire de Morrot, Alexandre |
| dc.subject.other.pt_BR.fl_str_mv |
Lieshmaniose visceral Leishmania infantum chagasi Respostas protetoras do hospedeiro B-1 cells |
| topic |
Lieshmaniose visceral Leishmania infantum chagasi Respostas protetoras do hospedeiro B-1 cells visceral leishmaniasis Leishmania (L.) infantum chagasi B-1 cells host protective responses |
| dc.subject.en.pt_BR.fl_str_mv |
visceral leishmaniasis Leishmania (L.) infantum chagasi B-1 cells host protective responses |
| description |
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. |
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2017 |
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2017-07-06T12:23:27Z |
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2017-07-06T12:23:27Z |
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2017 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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ARCANJO, Angélica Fernandes; et al. Dependency of B-1 Cells in the Maintenance of Splenic Interleukin-10 Producing Cells and Impairment of Macrophage Resistance in Visceral Leishmaniasis. Frontiers in Microbiology, v.8, Article 978, 7p, June 2017. |
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https://www.arca.fiocruz.br/handle/icict/19736 |
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1664-302X |
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10.3389/fmicb.2017.00978 |
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ARCANJO, Angélica Fernandes; et al. Dependency of B-1 Cells in the Maintenance of Splenic Interleukin-10 Producing Cells and Impairment of Macrophage Resistance in Visceral Leishmaniasis. Frontiers in Microbiology, v.8, Article 978, 7p, June 2017. 1664-302X 10.3389/fmicb.2017.00978 |
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