A case of conventional treatment failure in visceral leishmaniasis: leukocyte distribution and cytokine expression in splenic compartments.

Detalhes bibliográficos
Autor(a) principal: dosSantos, Washington Luis Conrado
Data de Publicação: 2014
Outros Autores: Pagliari, Carla, Santos, Lina G., Almeida, Valter dos Anjos, Silva, Thiago L. V. e, Coutinho Junior, João de J, Souza, Tulio, Duarte, Maria Irma Seixas, Freitas, Luiz Antonio Rodrigues de, Costa, Carlos Henrique Nery
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8709
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
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spelling dosSantos, Washington Luis ConradoPagliari, CarlaSantos, Lina G.Almeida, Valter dos AnjosSilva, Thiago L. V. eCoutinho Junior, João de JSouza, TulioDuarte, Maria Irma SeixasFreitas, Luiz Antonio Rodrigues deCosta, Carlos Henrique Nery2014-10-31T19:20:02Z2014-10-31T19:20:02Z2014SANTOS, Washington Luis Conrado dos et al. A case of conventional treatment failure in visceral leishmaniasis: leukocyte distribution and cytokine expression in splenic compartments. BMC Infectious Diseses, v. 14, p. 491, 2014.1471-2334https://www.arca.fiocruz.br/handle/icict/870910.1186/1471-2334-14-491engBioMed CentralA case of conventional treatment failure in visceral leishmaniasis: leukocyte distribution and cytokine expression in splenic compartments.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil.Universidade Federal do Piauí. Instituto de Doenças Tropicais Natan Portela. Teresina, PI, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal do Piauí. Instituto de Doenças Tropicais Natan Portela. Teresina, PI, Brasil.Universidade Federal do Piauí. Instituto de Doenças Tropicais Natan Portela. Teresina, PI, Brasil.Hospital Aliança. Salvador, BA, Brasil.Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal do Piauí. Instituto de Doenças Tropicais Natan Portela. Teresina, PI, Brasil.BACKGROUND: In this paper we study the distribution of leukocyte populations and of cytokine-producing cells in the spleen of a patient with visceral leishmaniasis resistant to clinical treatment. It is the first attempt to compare the distribution of leukocyte populations and cytokine-producing cells in the splenic compartments of a patient with visceral leishmaniasis with those observed in patients without the disease. CASE PRESENTATION: A 25-year-old male, farmer, was hospitalized on several occasions with diagnosis of visceral leishmaniasis and received all recommended treatments for the disease with only transient improvement followed by relapse. He was eventually subjected to splenectomy in order to control the effects of hypersplenism and to potentially overcome infection. After surgery and combined chemotherapy, the disease evolved to cure. In comparison with the spleens of the other two patients without visceral leishmaniasis, an increase was observed in the CD4/CD8 ratio and in the number of IL-10- and FoxP3-producing cells, while the number of IL-17-producing cells was lower in the spleen of the patient with visceral leishmaniasis. CONCLUSION: This report confirms previous data on changes in the CD4/CD8 ratio in the spleens of patients with visceral leishmaniasis. Additionally the data presented herein suggests that splenic FoxP3- and IL-17-producing cells are involved in the chronicity of visceral leishmaniasis.Visceral leishmaniasisSpleenCytokinesLeukocyte populationsLeishmania infantum, Leishmania chagasiinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALDos-Santos WL A case of....pdfDos-Santos WL A case of....pdfapplication/pdf1441673https://www.arca.fiocruz.br/bitstream/icict/8709/2/Dos-Santos%20WL%20A%20case%20of....pdf9485995d5b195c7f3c4290b3fca05d19MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8709/3/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD53TEXTDos-Santos WL A case of....pdf.txtDos-Santos WL A case of....pdf.txtExtracted texttext/plain22347https://www.arca.fiocruz.br/bitstream/icict/8709/4/Dos-Santos%20WL%20A%20case%20of....pdf.txt3bcb058fb6fddf20e7b0c7351433a2b1MD54icict/87092023-03-15 14:34:16.471oai:www.arca.fiocruz.br:icict/8709TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGNvbmNvcmRhciBlIGFjZWl0YXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKToKCmEpIERlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zDrXRpY2EgZGUgY29weXJpZ2h0IGRhIGVkaXRvcmEgZG8gc2V1IGRvY3VtZW50by4KCmIpIERlY2xhcmEgcXVlIGNvbmhlY2UgZSBhY2VpdGEgYXMgRGlyZXRyaXplcyBwYXJhIG8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgRnVuZGHDp8OjbyBPc3dhbGRvIENydXogKEZJT0NSVVopLgoKYykgQ29uY2VkZSDDoCBGSU9DUlVaIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyCiAKZS9vdSBkaXN0cmlidWlyIG5vIFJlcG9zaXTDs3JpbyBkYSBGSU9DUlVaLCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgCgpwb3IgcXVhbHF1ZXIgb3V0cm8gbWVpby4KCmQpIERlY2xhcmEgcXVlIGF1dG9yaXphIGEgRklPQ1JVWiBhIGFycXVpdmFyIG1haXMgZGUgdW1hIGPDs3BpYSBkZXN0ZSBkb2N1bWVudG8gZSBjb252ZXJ0w6otbG8sIHNlbSBhbHRlcmFyIG8gc2V1IGNvbnRlw7pkbywgCgpwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgYXJxdWl2bywgbWVpbyBvdSBzdXBvcnRlLCBwYXJhIGVmZWl0b3MgZGUgc2VndXJhbsOnYSwgcHJlc2VydmHDp8OjbyAoYmFja3VwKSBlIGFjZXNzby4KCmUpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBhIHRlcmNlaXJvcyBvcyBkaXJlaXRvcyAKCmNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuCgpmKSBEZWNsYXJhIHF1ZSwgbm8gY2FzbyBkbyBkb2N1bWVudG8gc3VibWV0aWRvIGNvbnRlciBtYXRlcmlhbCBkbyBxdWFsIG7Do28gZGV0w6ltIG9zIGRpcmVpdG9zIGRlIGF1dG9yLCBvYnRldmUgYSBhdXRvcml6YcOnw6NvIAoKaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhIEZJT0NSVVogb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIAoKdXRpbGl6w6EtbG9zIGxlZ2FsbWVudGUuIERlY2xhcmEgdGFtYsOpbSBxdWUgZXNzZSBtYXRlcmlhbCBjdWpvcyBkaXJlaXRvcyBzw6NvIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlIGlkZW50aWZpY2FkbyBlIHJlY29uaGVjaWRvIAoKbm8gdGV4dG8gb3UgY29udGXDumRvIGRvIGRvY3VtZW50byBlbnRyZWd1ZS4KCmcpIFNFIE8gRE9DVU1FTlRPIEVOVFJFR1VFIMOJIEJBU0VBRE8gRU0gVFJBQkFMSE8gRklOQU5DSUFETyBPVSBBUE9JQURPIFBPUiBPVVRSQSBJTlNUSVRVScOHw4NPIFFVRSBOw4NPIEEgRklPQ1JVWiwgREVDTEFSQSBRVUUgQ1VNUFJJVSAKClFVQUlTUVVFUiBPQlJJR0HDh8OVRVMgRVhJR0lEQVMgUEVMTyBSRVNQRUNUSVZPIENPTlRSQVRPIE9VIEFDT1JETy4gQSBGSU9DUlVaIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBvKHMpIG5vbWUocykgZG8ocykgYXV0b3IoZXMpIGRvcyAKCmRpcmVpdG9zIGRvIGRvY3VtZW50byBlbnRyZWd1ZSBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIHBhcmEgYWzDqW0gZG8gcHJldmlzdG8gbmEgYWzDrW5lYSBjKS4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:16Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv A case of conventional treatment failure in visceral leishmaniasis: leukocyte distribution and cytokine expression in splenic compartments.
title A case of conventional treatment failure in visceral leishmaniasis: leukocyte distribution and cytokine expression in splenic compartments.
spellingShingle A case of conventional treatment failure in visceral leishmaniasis: leukocyte distribution and cytokine expression in splenic compartments.
dosSantos, Washington Luis Conrado
Visceral leishmaniasis
Spleen
Cytokines
Leukocyte populations
Leishmania infantum, Leishmania chagasi
title_short A case of conventional treatment failure in visceral leishmaniasis: leukocyte distribution and cytokine expression in splenic compartments.
title_full A case of conventional treatment failure in visceral leishmaniasis: leukocyte distribution and cytokine expression in splenic compartments.
title_fullStr A case of conventional treatment failure in visceral leishmaniasis: leukocyte distribution and cytokine expression in splenic compartments.
title_full_unstemmed A case of conventional treatment failure in visceral leishmaniasis: leukocyte distribution and cytokine expression in splenic compartments.
title_sort A case of conventional treatment failure in visceral leishmaniasis: leukocyte distribution and cytokine expression in splenic compartments.
author dosSantos, Washington Luis Conrado
author_facet dosSantos, Washington Luis Conrado
Pagliari, Carla
Santos, Lina G.
Almeida, Valter dos Anjos
Silva, Thiago L. V. e
Coutinho Junior, João de J
Souza, Tulio
Duarte, Maria Irma Seixas
Freitas, Luiz Antonio Rodrigues de
Costa, Carlos Henrique Nery
author_role author
author2 Pagliari, Carla
Santos, Lina G.
Almeida, Valter dos Anjos
Silva, Thiago L. V. e
Coutinho Junior, João de J
Souza, Tulio
Duarte, Maria Irma Seixas
Freitas, Luiz Antonio Rodrigues de
Costa, Carlos Henrique Nery
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv dosSantos, Washington Luis Conrado
Pagliari, Carla
Santos, Lina G.
Almeida, Valter dos Anjos
Silva, Thiago L. V. e
Coutinho Junior, João de J
Souza, Tulio
Duarte, Maria Irma Seixas
Freitas, Luiz Antonio Rodrigues de
Costa, Carlos Henrique Nery
dc.subject.en.pt_BR.fl_str_mv Visceral leishmaniasis
Spleen
Cytokines
Leukocyte populations
Leishmania infantum, Leishmania chagasi
topic Visceral leishmaniasis
Spleen
Cytokines
Leukocyte populations
Leishmania infantum, Leishmania chagasi
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
publishDate 2014
dc.date.accessioned.fl_str_mv 2014-10-31T19:20:02Z
dc.date.available.fl_str_mv 2014-10-31T19:20:02Z
dc.date.issued.fl_str_mv 2014
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTOS, Washington Luis Conrado dos et al. A case of conventional treatment failure in visceral leishmaniasis: leukocyte distribution and cytokine expression in splenic compartments. BMC Infectious Diseses, v. 14, p. 491, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8709
dc.identifier.issn.none.fl_str_mv 1471-2334
dc.identifier.doi.none.fl_str_mv 10.1186/1471-2334-14-491
identifier_str_mv SANTOS, Washington Luis Conrado dos et al. A case of conventional treatment failure in visceral leishmaniasis: leukocyte distribution and cytokine expression in splenic compartments. BMC Infectious Diseses, v. 14, p. 491, 2014.
1471-2334
10.1186/1471-2334-14-491
url https://www.arca.fiocruz.br/handle/icict/8709
dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv BioMed Central
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