Protection and pathology in leishmania braziliensis infection

Bibliographic Details
Main Author: Carvalho, Augusto M
Publication Date: 2022
Other Authors: Bacellar, Olívia, Carvalho, Edgar M
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/54866
Summary: Institutos Nacionais de Saúde. Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Conselho Brasileiro de Desenvolvimento Científico e Tecnológico (CNPq).
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spelling Carvalho, Augusto MBacellar, OlíviaCarvalho, Edgar M2022-09-23T19:25:06Z2022-09-23T19:25:06Z2022CARVALHO, Augusto M; BACELLAR, Olívia; CARVALHO, Edgar M. Protection and Pathology in Leishmania braziliensis Infection. Pathogens, v. 11, n. 4, p. 1-11, 2022.2076-0817https://www.arca.fiocruz.br/handle/icict/5486610.3390/pathogens11040466Institutos Nacionais de Saúde. Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Conselho Brasileiro de Desenvolvimento Científico e Tecnológico (CNPq).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Salvador, BA, Brasil.Leishmania killing is mediated by IFN-γ-activated macrophages, but IFN-γ production and macrophage activation are insufficient to control L. braziliensis infection. In American tegumentary leishmaniasis (ATL), pathology results from an exaggerated inflammatory response. This report presents an overview of our contributions regarding ATL pathogenesis, highlighting future directions to improve the management of L. braziliensis infection. Monocytes and lymphocytes from individuals exposed to L. braziliensis but who do not develop CL, i.e., subclinical infection (SC), exhibit lower respiratory burst and IFN-γ production, yet more efficiently kill L. braziliensis. As vaccines aimed at inducing IL-12 and IFN-γ do not sufficiently prevent CL, the elucidation of how subjects with SC infection kill Leishmania may lead to new approaches to controlling ATL. While inflammation arising from the recruitment of inflammatory cells via chemokines induced by IFN-γ and TNF or IL-17 is observed and contributes to pathology, cytotoxic CD8+ T cells and NK cells play a key role in the pathogenesis of L. braziliensis infection. The increased transcription of genes related to inflammation and cytotoxicity, e.g., granzyme A, granzyme B, NLRP3 and IL-1β, has been documented in CL tissue samples. The release of products by killed cells leads to NLRP3 inflammasome activation, IL-1β production and additional damage to skin and mucosal tissues. The use of drugs that downmodulate the inflammatory response in combination with chemotherapy improves the ATL cure rate and decreases healing time.engMDPILeishmaniasisLeishmania braziliensisParasitic DiseasesPathologyLeishmanioseLeishmania braziliensisInfecção parasitáriaPatologiaAmerican tegumentary leishmaniasisLeishmaniasisLeishmania braziliensisParasitic DiseasesPathologyAmerican tegumentary leishmaniasisProtection and pathology in leishmania braziliensis infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCarvalho, Augusto - Protection and pathology in Leishmania braziliensis Infection.pdfCarvalho, Augusto - Protection and pathology in Leishmania braziliensis Infection.pdfapplication/pdf998966https://www.arca.fiocruz.br/bitstream/icict/54866/2/Carvalho%2c%20Augusto%20-%20Protection%20and%20pathology%20in%20Leishmania%20braziliensis%20Infection.pdf852988f6e3ed4957b7c1f101dcd281faMD52LICENSElicense.txtlicense.txttext/plain; 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dc.title.en_US.fl_str_mv Protection and pathology in leishmania braziliensis infection
title Protection and pathology in leishmania braziliensis infection
spellingShingle Protection and pathology in leishmania braziliensis infection
Carvalho, Augusto M
Leishmaniasis
Leishmania braziliensis
Parasitic Diseases
Pathology
Leishmaniose
Leishmania braziliensis
Infecção parasitária
Patologia
American tegumentary leishmaniasis
Leishmaniasis
Leishmania braziliensis
Parasitic Diseases
Pathology
American tegumentary leishmaniasis
title_short Protection and pathology in leishmania braziliensis infection
title_full Protection and pathology in leishmania braziliensis infection
title_fullStr Protection and pathology in leishmania braziliensis infection
title_full_unstemmed Protection and pathology in leishmania braziliensis infection
title_sort Protection and pathology in leishmania braziliensis infection
author Carvalho, Augusto M
author_facet Carvalho, Augusto M
Bacellar, Olívia
Carvalho, Edgar M
author_role author
author2 Bacellar, Olívia
Carvalho, Edgar M
author2_role author
author
dc.contributor.author.fl_str_mv Carvalho, Augusto M
Bacellar, Olívia
Carvalho, Edgar M
dc.subject.mesh.en_US.fl_str_mv Leishmaniasis
Leishmania braziliensis
Parasitic Diseases
Pathology
topic Leishmaniasis
Leishmania braziliensis
Parasitic Diseases
Pathology
Leishmaniose
Leishmania braziliensis
Infecção parasitária
Patologia
American tegumentary leishmaniasis
Leishmaniasis
Leishmania braziliensis
Parasitic Diseases
Pathology
American tegumentary leishmaniasis
dc.subject.other.en_US.fl_str_mv Leishmaniose
Leishmania braziliensis
Infecção parasitária
Patologia
American tegumentary leishmaniasis
dc.subject.en.en_US.fl_str_mv Leishmaniasis
Leishmania braziliensis
Parasitic Diseases
Pathology
American tegumentary leishmaniasis
description Institutos Nacionais de Saúde. Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Conselho Brasileiro de Desenvolvimento Científico e Tecnológico (CNPq).
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-09-23T19:25:06Z
dc.date.available.fl_str_mv 2022-09-23T19:25:06Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARVALHO, Augusto M; BACELLAR, Olívia; CARVALHO, Edgar M. Protection and Pathology in Leishmania braziliensis Infection. Pathogens, v. 11, n. 4, p. 1-11, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/54866
dc.identifier.issn.en_US.fl_str_mv 2076-0817
dc.identifier.doi.none.fl_str_mv 10.3390/pathogens11040466
identifier_str_mv CARVALHO, Augusto M; BACELLAR, Olívia; CARVALHO, Edgar M. Protection and Pathology in Leishmania braziliensis Infection. Pathogens, v. 11, n. 4, p. 1-11, 2022.
2076-0817
10.3390/pathogens11040466
url https://www.arca.fiocruz.br/handle/icict/54866
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/54866/2/Carvalho%2c%20Augusto%20-%20Protection%20and%20pathology%20in%20Leishmania%20braziliensis%20Infection.pdf
https://www.arca.fiocruz.br/bitstream/icict/54866/1/license.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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