Synthesis and antitubercular activity of new mefloquine-oxazolidine derivatives

Detalhes bibliográficos
Autor(a) principal: Gonçalves, Raoni S. B.
Data de Publicação: 2010
Outros Autores: Kaiser, Carlos R., Lourenço, Maria C. S., Souza, Marcus V. N. de, Wardell, James L., Wardell, Solange M. S. V., Silva, Adilson D. da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/37441
Resumo: 2020-11-28
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spelling Gonçalves, Raoni S. B.Kaiser, Carlos R.Lourenço, Maria C. S.Souza, Marcus V. N. deWardell, James L.Wardell, Solange M. S. V.Silva, Adilson D. da2019-11-28T13:03:41Z2019-11-28T13:03:41Z2010GONÇALVES, Raoni S. B. et al. Synthesis and antitubercular activity of new mefloquine-oxazolidine derivatives. European Journal of Medicinal Chemistry, v. 45, p. 6095-6100, 2010.0223-5234https://www.arca.fiocruz.br/handle/icict/3744110.1016/j.ejmech.2010.09.0241768-3254engElsevierSynthesis and antitubercular activity of new mefloquine-oxazolidine derivativesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-11-28Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Química. Programa de Pós-Graduação em Química. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Química. Programa de Pós-Graduação em Química. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisas Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Química. Programa de Pós-Graduação em Química. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil.CHEMSOL. Aberdeen, Scotland, UK.Universidade Federal de Juiz de Fora. Instituto de Ciências Exatas. Departamento de Química. Juiz de Fora, MG, Brasil.In this work, we report the synthesis and the antitubercular evaluation of 16 new mefloquine derivatives, formed from reactions between mefloquine and benzaldehydes, with the activity expressed as the minimum inhibitory concentration (MIC) in mM. The compounds were non-cytotoxic and exhibited an important activity (12.6 mM). The appreciable activity of these compounds can be considered an important finding for the rational design of new leads for anti-TB compounds.TuberculosisQuinolineMefloquineinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/37441/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Gonçalves_Raoni_etal_INI_2010.pdfve_Gonçalves_Raoni_etal_INI_2010.pdfapplication/pdf433365https://www.arca.fiocruz.br/bitstream/icict/37441/2/ve_Gon%c3%a7alves_Raoni_etal_INI_2010.pdf89dcc56795d2a4f7e727ad7c429a29e2MD52TEXTve_Gonçalves_Raoni_etal_INI_2010.pdf.txtve_Gonçalves_Raoni_etal_INI_2010.pdf.txtExtracted texttext/plain36388https://www.arca.fiocruz.br/bitstream/icict/37441/3/ve_Gon%c3%a7alves_Raoni_etal_INI_2010.pdf.txtd7f0588681660163d48a41ffd445a3f4MD53icict/374412021-03-24 16:32:40.134oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:40Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Synthesis and antitubercular activity of new mefloquine-oxazolidine derivatives
title Synthesis and antitubercular activity of new mefloquine-oxazolidine derivatives
spellingShingle Synthesis and antitubercular activity of new mefloquine-oxazolidine derivatives
Gonçalves, Raoni S. B.
Tuberculosis
Quinoline
Mefloquine
title_short Synthesis and antitubercular activity of new mefloquine-oxazolidine derivatives
title_full Synthesis and antitubercular activity of new mefloquine-oxazolidine derivatives
title_fullStr Synthesis and antitubercular activity of new mefloquine-oxazolidine derivatives
title_full_unstemmed Synthesis and antitubercular activity of new mefloquine-oxazolidine derivatives
title_sort Synthesis and antitubercular activity of new mefloquine-oxazolidine derivatives
author Gonçalves, Raoni S. B.
author_facet Gonçalves, Raoni S. B.
Kaiser, Carlos R.
Lourenço, Maria C. S.
Souza, Marcus V. N. de
Wardell, James L.
Wardell, Solange M. S. V.
Silva, Adilson D. da
author_role author
author2 Kaiser, Carlos R.
Lourenço, Maria C. S.
Souza, Marcus V. N. de
Wardell, James L.
Wardell, Solange M. S. V.
Silva, Adilson D. da
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gonçalves, Raoni S. B.
Kaiser, Carlos R.
Lourenço, Maria C. S.
Souza, Marcus V. N. de
Wardell, James L.
Wardell, Solange M. S. V.
Silva, Adilson D. da
dc.subject.en.pt_BR.fl_str_mv Tuberculosis
Quinoline
Mefloquine
topic Tuberculosis
Quinoline
Mefloquine
description 2020-11-28
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2019-11-28T13:03:41Z
dc.date.available.fl_str_mv 2019-11-28T13:03:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GONÇALVES, Raoni S. B. et al. Synthesis and antitubercular activity of new mefloquine-oxazolidine derivatives. European Journal of Medicinal Chemistry, v. 45, p. 6095-6100, 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/37441
dc.identifier.issn.pt_BR.fl_str_mv 0223-5234
dc.identifier.doi.none.fl_str_mv 10.1016/j.ejmech.2010.09.024
dc.identifier.eissn.none.fl_str_mv 1768-3254
identifier_str_mv GONÇALVES, Raoni S. B. et al. Synthesis and antitubercular activity of new mefloquine-oxazolidine derivatives. European Journal of Medicinal Chemistry, v. 45, p. 6095-6100, 2010.
0223-5234
10.1016/j.ejmech.2010.09.024
1768-3254
url https://www.arca.fiocruz.br/handle/icict/37441
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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