Synthesis and in vitro antitubercular activity of a series of quinoline derivatives

Detalhes bibliográficos
Autor(a) principal: Souza, Marcus V. N. de
Data de Publicação: 2009
Outros Autores: Pais, Karla C., Kaiser, Carlos R., Peralta, Mônica A., Ferreira, Marcelle de L., Lourenço, Maria C. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/38823
Resumo: 2020-12-26
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spelling Souza, Marcus V. N. dePais, Karla C.Kaiser, Carlos R.Peralta, Mônica A.Ferreira, Marcelle de L.Lourenço, Maria C. S.2019-12-26T12:41:29Z2019-12-26T12:41:29Z2009SOUZA, Marcus V. N. de et al. Synthesis and in vitro antitubercular activity of a series of quinoline derivatives. Bioorganic and Medicinal Chemistry, v. 17, p. 1474-1480, 2009.0968-0896https://www.arca.fiocruz.br/handle/icict/3882310.1016/j.bmc.2009.01.013engElsevierSynthesis and in vitro antitubercular activity of a series of quinoline derivativesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-12-26Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Química. Departamento de Química Orgânica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Química. Departamento de Química Orgânica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Química. Departamento de Química Orgânica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.A series of 33 quinoline derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using the Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC) inlg/mL. Compounds 5e and 5f exhibited asignificant activity at 6.25 and 3.12lg/mL, respectively, when compared with first line drugs such as ethambutol and could be a good starting point to develop new lead compounds in the fight against multidrug resistant tuberculosis.QuinolineDrugsMDR-TBAntitubercular activityinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/38823/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Souza_Marcus_etal_INI_2009.pdfve_Souza_Marcus_etal_INI_2009.pdfapplication/pdf445079https://www.arca.fiocruz.br/bitstream/icict/38823/2/ve_Souza_Marcus_etal_INI_2009.pdfe7b2e0e0ee70a7fb8a3a6046cf10a8fbMD52TEXTve_Souza_Marcus_etal_INI_2009.pdf.txtve_Souza_Marcus_etal_INI_2009.pdf.txtExtracted texttext/plain35312https://www.arca.fiocruz.br/bitstream/icict/38823/3/ve_Souza_Marcus_etal_INI_2009.pdf.txt59328b4c271138192d4661a544ed5e30MD53icict/388232021-03-24 16:32:41.013oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:41Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Synthesis and in vitro antitubercular activity of a series of quinoline derivatives
title Synthesis and in vitro antitubercular activity of a series of quinoline derivatives
spellingShingle Synthesis and in vitro antitubercular activity of a series of quinoline derivatives
Souza, Marcus V. N. de
Quinoline
Drugs
MDR-TB
Antitubercular activity
title_short Synthesis and in vitro antitubercular activity of a series of quinoline derivatives
title_full Synthesis and in vitro antitubercular activity of a series of quinoline derivatives
title_fullStr Synthesis and in vitro antitubercular activity of a series of quinoline derivatives
title_full_unstemmed Synthesis and in vitro antitubercular activity of a series of quinoline derivatives
title_sort Synthesis and in vitro antitubercular activity of a series of quinoline derivatives
author Souza, Marcus V. N. de
author_facet Souza, Marcus V. N. de
Pais, Karla C.
Kaiser, Carlos R.
Peralta, Mônica A.
Ferreira, Marcelle de L.
Lourenço, Maria C. S.
author_role author
author2 Pais, Karla C.
Kaiser, Carlos R.
Peralta, Mônica A.
Ferreira, Marcelle de L.
Lourenço, Maria C. S.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Souza, Marcus V. N. de
Pais, Karla C.
Kaiser, Carlos R.
Peralta, Mônica A.
Ferreira, Marcelle de L.
Lourenço, Maria C. S.
dc.subject.en.pt_BR.fl_str_mv Quinoline
Drugs
MDR-TB
Antitubercular activity
topic Quinoline
Drugs
MDR-TB
Antitubercular activity
description 2020-12-26
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2019-12-26T12:41:29Z
dc.date.available.fl_str_mv 2019-12-26T12:41:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOUZA, Marcus V. N. de et al. Synthesis and in vitro antitubercular activity of a series of quinoline derivatives. Bioorganic and Medicinal Chemistry, v. 17, p. 1474-1480, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/38823
dc.identifier.issn.pt_BR.fl_str_mv 0968-0896
dc.identifier.doi.none.fl_str_mv 10.1016/j.bmc.2009.01.013
identifier_str_mv SOUZA, Marcus V. N. de et al. Synthesis and in vitro antitubercular activity of a series of quinoline derivatives. Bioorganic and Medicinal Chemistry, v. 17, p. 1474-1480, 2009.
0968-0896
10.1016/j.bmc.2009.01.013
url https://www.arca.fiocruz.br/handle/icict/38823
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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