Assessment of Galectin-3 Polymorphism in Subjects with Chronic Chagas Disease.

Detalhes bibliográficos
Autor(a) principal: Cruz, Gabriela da Silva
Data de Publicação: 2015
Outros Autores: Angelo, Ana Luiza Dias, Larocca, Ticiana Ferreira, Macedo, Carolina Thé, Rabelo, Márcia Noya, Correia, Luis Cláudio Lemos, Torreão, Jorge Andion, Souza, Bruno Solano de Freitas, Santos, Ricardo Ribeiro dos, Soares, Milena Botelho Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13253
Resumo: Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil
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spelling Cruz, Gabriela da SilvaAngelo, Ana Luiza DiasLarocca, Ticiana FerreiraMacedo, Carolina ThéRabelo, Márcia NoyaCorreia, Luis Cláudio LemosTorreão, Jorge AndionSouza, Bruno Solano de FreitasSantos, Ricardo Ribeiro dosSoares, Milena Botelho Pereira2016-03-23T13:35:11Z2016-03-23T13:35:11Z2015CRUZ, G. S. et al. Assessment of Galectin-3 Polymorphism in Subjects with Chronic Chagas Disease. Arquivo Brasileiro de Cardiologia, v. 105, n. 5, p. 472-478, 2015.1678-417010.5935/abc.20150105https://www.arca.fiocruz.br/handle/icict/13253engSociedade Brasileira de CardiologiaAssessment of Galectin-3 Polymorphism in Subjects with Chronic Chagas Disease.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, BrasilHospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, BrasilHospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Departamento de Cardiologia. Salvador, BA, BrasilHospital São Rafael. Departamento de Cardiologia. Salvador, BA, BrasilHospital São Rafael. Departamento de Cardiologia. Salvador, BA, BrasilHospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilBACKGROUND: Galectin-3, a ß-galactoside binding lectin, has been described as a mediator of cardiac fibrosis in experimental studies and as a risk factor associated with cardiovascular events in subjects with heart failure. Previous studies have evaluated the genetic susceptibility to Chagas disease in humans, including the polymorphisms of cytokine genes, demonstrating correlations between the genetic polymorphism and cardiomyopathy development in the chronic phase. However, the relationship between the galectin-3 single nucleotide polymorphism (SNP) and phenotypic variations in Chagas disease has not been evaluated. OBJECTIVE: The present study aimed to determine whether genetic polymorphisms of galectin-3 may predispose to the development of cardiac forms of Chagas disease. METHODS: Fifty-five subjects with Chagas disease were enrolled in this observational study. Real-time polymerase chain reaction (PCR) was used for genotyping the variants rs4644 and rs4652 of the galectin-3 gene. RESULTS: For the SNP rs4644, the relative risk for the cardiac form was not associated with the genotypes AA (OR = 0.79, p = 0.759), AC (OR = 4.38, p = 0.058), or CC (OR = 0.39, p = 0.127). Similarly, for the SNP rs4652, no association was found between the genotypes AA (OR = 0.64, p = 0.571), AC (OR = 2.85, p = 0.105), or CC (OR = 0.49, p = 0.227) and the cardiac form of the disease. CONCLUSION: Our results showed no association between the different genotypes for both SNPs of the galectin-3 gene and the cardiac form of Chagas disease.Chagas DiseaseGalectin 3Heart FailurePolymorphismGeneticChagas Cardiomyopathyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13253/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCruz GS Assessment....pdfCruz GS Assessment....pdfapplication/pdf409829https://www.arca.fiocruz.br/bitstream/icict/13253/2/Cruz%20GS%20Assessment....pdf769c74faa40f7a24344a6dc548381ea6MD52TEXTCruz GS Assessment....pdf.txtCruz GS Assessment....pdf.txtExtracted texttext/plain24155https://www.arca.fiocruz.br/bitstream/icict/13253/3/Cruz%20GS%20Assessment....pdf.txt09856f5f5ba0e42b7f23707804e8570aMD53icict/132532023-03-15 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dc.title.pt_BR.fl_str_mv Assessment of Galectin-3 Polymorphism in Subjects with Chronic Chagas Disease.
title Assessment of Galectin-3 Polymorphism in Subjects with Chronic Chagas Disease.
spellingShingle Assessment of Galectin-3 Polymorphism in Subjects with Chronic Chagas Disease.
Cruz, Gabriela da Silva
Chagas Disease
Galectin 3
Heart Failure
Polymorphism
Genetic
Chagas Cardiomyopathy
title_short Assessment of Galectin-3 Polymorphism in Subjects with Chronic Chagas Disease.
title_full Assessment of Galectin-3 Polymorphism in Subjects with Chronic Chagas Disease.
title_fullStr Assessment of Galectin-3 Polymorphism in Subjects with Chronic Chagas Disease.
title_full_unstemmed Assessment of Galectin-3 Polymorphism in Subjects with Chronic Chagas Disease.
title_sort Assessment of Galectin-3 Polymorphism in Subjects with Chronic Chagas Disease.
author Cruz, Gabriela da Silva
author_facet Cruz, Gabriela da Silva
Angelo, Ana Luiza Dias
Larocca, Ticiana Ferreira
Macedo, Carolina Thé
Rabelo, Márcia Noya
Correia, Luis Cláudio Lemos
Torreão, Jorge Andion
Souza, Bruno Solano de Freitas
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
author_role author
author2 Angelo, Ana Luiza Dias
Larocca, Ticiana Ferreira
Macedo, Carolina Thé
Rabelo, Márcia Noya
Correia, Luis Cláudio Lemos
Torreão, Jorge Andion
Souza, Bruno Solano de Freitas
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cruz, Gabriela da Silva
Angelo, Ana Luiza Dias
Larocca, Ticiana Ferreira
Macedo, Carolina Thé
Rabelo, Márcia Noya
Correia, Luis Cláudio Lemos
Torreão, Jorge Andion
Souza, Bruno Solano de Freitas
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
dc.subject.en.pt_BR.fl_str_mv Chagas Disease
Galectin 3
Heart Failure
Polymorphism
Genetic
Chagas Cardiomyopathy
topic Chagas Disease
Galectin 3
Heart Failure
Polymorphism
Genetic
Chagas Cardiomyopathy
description Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-03-23T13:35:11Z
dc.date.available.fl_str_mv 2016-03-23T13:35:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CRUZ, G. S. et al. Assessment of Galectin-3 Polymorphism in Subjects with Chronic Chagas Disease. Arquivo Brasileiro de Cardiologia, v. 105, n. 5, p. 472-478, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13253
dc.identifier.issn.none.fl_str_mv 1678-4170
10.5935/abc.20150105
identifier_str_mv CRUZ, G. S. et al. Assessment of Galectin-3 Polymorphism in Subjects with Chronic Chagas Disease. Arquivo Brasileiro de Cardiologia, v. 105, n. 5, p. 472-478, 2015.
1678-4170
10.5935/abc.20150105
url https://www.arca.fiocruz.br/handle/icict/13253
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia
publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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