Levels of interferon-gamma increase after treatment for latent tuberculosis infection in a high-transmission setting.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1155/2012/757152 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7201 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Advanced Laboratory of Public Health. Salvador, BA, Brasil |
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Takenami, Iukary OliveiraFinkmoore, BrookMachado Junior, AlmérioEmodi, KrisztinaRiley, Lee WoodlandArruda, Sérgio Marcos2013-10-24T18:04:01Z2013-10-24T18:04:01Z2012TAKENAMI, I. et el. Levels of interferon-gamma increase after treatment for latent tuberculosis infection in a high-transmission setting. Pulmonary Medicine, p. 1-6, 2012.2090-1844https://www.arca.fiocruz.br/handle/icict/720110.1155/2012/757152engHindawi Publishing CorporationLevels of interferon-gamma increase after treatment for latent tuberculosis infection in a high-transmission setting.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Advanced Laboratory of Public Health. Salvador, BA, BrasilUniversity of California. School of Public Health. Division of Infectious Diseases & Vaccinology. Berkeley, CA, USABahia School of Medicine and Public Health. Salvador, BA, Brasil / Hospital Especializado Octávio Mangabeira. Secretary of Health of Bahia State. Salvador, BA, BrasilUniversity of California. School of Public Health. Division of Infectious Diseases & Vaccinology. Berkeley, CA, USAUniversity of California. School of Public Health. Division of Infectious Diseases & Vaccinology. Berkeley, CA, USAFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Advanced Laboratory of Public Health. Salvador, BA, Brasil /Bahia School of Medicine and Public Health. Salvador, BA, Brasil / Hospital Especializado Octávio Mangabeira. Secretary of Health of Bahia State. Salvador, BA, BrasilObjectives. We investigated IFN-γ levels before and after a six month course of isoniazid among individuals with latent tuberculosis infection (LTBI) in a high-transmission setting. Design. A total of 26 household contacts of pulmonary tuberculosis patients who were positive for LTBI by tuberculin skin test completed six months of treatment and submitted a blood sample for a followup examination. The IFN-γ response to Mycobacterium tuberculosis-specific antigens was measured, and the results before and after the completion of LTBI treatment were compared. Results. Of the 26 study participants, 25 (96%) showed an IFN-γ level higher than their baseline level before treatment (P ≤ 0.001). Only one individual had a decreased IFN-γ level after treatment but remained positive for LTBI. Conclusion. In a high-transmission setting, the IFN-γ level has increased after LTBI treatment. Further studies must be undertaken to understand if this elevation is transient.Mycobacterium tuberculosisTuberculose latenteTransmissaoTeste tuberculínicoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALIukary Takenami Levels of interferon....pdfIukary Takenami Levels of interferon....pdfapplication/pdf1428110https://www.arca.fiocruz.br/bitstream/icict/7201/1/Iukary%20Takenami%20Levels%20of%20interferon....pdff58398f3bf3d59a7040d34605cac79bbMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81867https://www.arca.fiocruz.br/bitstream/icict/7201/2/license.txt89d048e714e969a1adcda05fdb1978beMD52TEXTIukary Takenami Levels of interferon....pdf.txtIukary Takenami Levels of interferon....pdf.txtExtracted texttext/plain30189https://www.arca.fiocruz.br/bitstream/icict/7201/5/Iukary%20Takenami%20Levels%20of%20interferon....pdf.txt50733303a93a249a6bc25d5dc1c0087cMD55THUMBNAILIukary Takenami Levels of interferon....pdf.jpgIukary Takenami Levels of interferon....pdf.jpgGenerated Thumbnailimage/jpeg1709https://www.arca.fiocruz.br/bitstream/icict/7201/4/Iukary%20Takenami%20Levels%20of%20interferon....pdf.jpg5aa8d88e9a01da93cc24fec5e43e1801MD54icict/72012023-03-15 14:32:54.943oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:54Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Levels of interferon-gamma increase after treatment for latent tuberculosis infection in a high-transmission setting. |
| title |
Levels of interferon-gamma increase after treatment for latent tuberculosis infection in a high-transmission setting. |
| spellingShingle |
Levels of interferon-gamma increase after treatment for latent tuberculosis infection in a high-transmission setting. Takenami, Iukary Oliveira Mycobacterium tuberculosis Tuberculose latente Transmissao Teste tuberculínico |
| title_short |
Levels of interferon-gamma increase after treatment for latent tuberculosis infection in a high-transmission setting. |
| title_full |
Levels of interferon-gamma increase after treatment for latent tuberculosis infection in a high-transmission setting. |
| title_fullStr |
Levels of interferon-gamma increase after treatment for latent tuberculosis infection in a high-transmission setting. |
| title_full_unstemmed |
Levels of interferon-gamma increase after treatment for latent tuberculosis infection in a high-transmission setting. |
| title_sort |
Levels of interferon-gamma increase after treatment for latent tuberculosis infection in a high-transmission setting. |
| author |
Takenami, Iukary Oliveira |
| author_facet |
Takenami, Iukary Oliveira Finkmoore, Brook Machado Junior, Almério Emodi, Krisztina Riley, Lee Woodland Arruda, Sérgio Marcos |
| author_role |
author |
| author2 |
Finkmoore, Brook Machado Junior, Almério Emodi, Krisztina Riley, Lee Woodland Arruda, Sérgio Marcos |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Takenami, Iukary Oliveira Finkmoore, Brook Machado Junior, Almério Emodi, Krisztina Riley, Lee Woodland Arruda, Sérgio Marcos |
| dc.subject.decs.pt_BR.fl_str_mv |
Mycobacterium tuberculosis Tuberculose latente Transmissao Teste tuberculínico |
| topic |
Mycobacterium tuberculosis Tuberculose latente Transmissao Teste tuberculínico |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Advanced Laboratory of Public Health. Salvador, BA, Brasil |
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2012 |
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2012 |
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2013-10-24T18:04:01Z |
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2013-10-24T18:04:01Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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TAKENAMI, I. et el. Levels of interferon-gamma increase after treatment for latent tuberculosis infection in a high-transmission setting. Pulmonary Medicine, p. 1-6, 2012. |
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https://www.arca.fiocruz.br/handle/icict/7201 |
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2090-1844 |
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10.1155/2012/757152 |
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TAKENAMI, I. et el. Levels of interferon-gamma increase after treatment for latent tuberculosis infection in a high-transmission setting. Pulmonary Medicine, p. 1-6, 2012. 2090-1844 10.1155/2012/757152 |
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Hindawi Publishing Corporation |
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