Blood cells and interferon-gamma levels correlation in latent tuberculosis infection

Detalhes bibliográficos
Autor(a) principal: Takenami, Iukary Oliveira
Data de Publicação: 2013
Outros Autores: Loureiro, Camila, Machado Junior, Almério, Emodi, Krisztina, Riley, Lee Woodland, Arruda, Sérgio Marcos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8801
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
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spelling Takenami, Iukary OliveiraLoureiro, CamilaMachado Junior, AlmérioEmodi, KrisztinaRiley, Lee WoodlandArruda, Sérgio Marcos2014-11-12T13:58:19Z2014-11-12T13:58:19Z2013TAKENAMI, I. et al. Blood cells and interferon-gamma levels correlation in latent tuberculosis infection. ISRN Pulmonology , p.1-8, 2013.2090-5769https://www.arca.fiocruz.br/handle/icict/8801dx.doi.org/10.1155/2013/256148engHindawi Publishing CorporationMycobacterium tuberculosisInfecçãoTeste tuberculínicoTuberculose pulmonaeBlood cells and interferon-gamma levels correlation in latent tuberculosis infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilBahia School of Medicine and Public Health. Salvador, BA, BrasilBahia School of Medicine and Public Health. Salvador, BA, Brasil / Hospital Especializado Octávio Mangabeira. Secretariat of Health of Bahia State. Salvador, BA, BrasilUniversity of California. Division of Infectious Diseases and Vaccinology. School of Public Health. Berkeley, USAUniversity of California. Division of Infectious Diseases and Vaccinology. School of Public Health. Berkeley, USAFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Bahia School of Medicine and Public Health. Salvador, BA, Brasile Mycobacterium tuberculosis (M. tb) infection is largely spread in world’s population. Most infected individuals develop latent tuberculosis infection (LTBI). Tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are the available tests to detect the infection. It has been reported that some individuals take a longer period of time to develop the infection than others with the same exposure level. It is suggested that the innate immunity, in which neutrophils have an important protective role, is responsible for this. Many hematologic abnormalities have been described as common ndings during severe disease. To investigate if these changes are related to LTBI development and if they interfere in TST and IFN- production, we recruited 88 household contacts of tuberculosis (TB) pulmonary patients and compared blood cell counts with these tests’ results. ere were no statistically signicant changes in hemoglobin, hematocrit, platelets, global leukocyte, neutrophils, basophils, eosinophils, typical lymphocytes, atypical lymphocytes, and monocytes counts between infected and noninfected individuals. Also, there was no correlation between TST or IGRA and blood cell counts. ese results suggest that blood cell counts are not LTBI markers and do not interfere in TST results or IFN- levels obtained by IGRA.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALTakenami I Blood cells....pdfTakenami I Blood cells....pdfapplication/pdf1445769https://www.arca.fiocruz.br/bitstream/icict/8801/2/Takenami%20I%20Blood%20cells....pdf95bc2ef96e25b70ec889ceaba75bbbecMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8801/3/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD53TEXTTakenami I Blood cells....pdf.txtTakenami I Blood cells....pdf.txtExtracted texttext/plain34746https://www.arca.fiocruz.br/bitstream/icict/8801/4/Takenami%20I%20Blood%20cells....pdf.txt15c7a3e399af2a179e5509fba03ab11bMD54icict/88012023-03-15 14:33:27.207oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:27Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Blood cells and interferon-gamma levels correlation in latent tuberculosis infection
title Blood cells and interferon-gamma levels correlation in latent tuberculosis infection
spellingShingle Blood cells and interferon-gamma levels correlation in latent tuberculosis infection
Takenami, Iukary Oliveira
Mycobacterium tuberculosis
Infecção
Teste tuberculínico
Tuberculose pulmonae
title_short Blood cells and interferon-gamma levels correlation in latent tuberculosis infection
title_full Blood cells and interferon-gamma levels correlation in latent tuberculosis infection
title_fullStr Blood cells and interferon-gamma levels correlation in latent tuberculosis infection
title_full_unstemmed Blood cells and interferon-gamma levels correlation in latent tuberculosis infection
title_sort Blood cells and interferon-gamma levels correlation in latent tuberculosis infection
author Takenami, Iukary Oliveira
author_facet Takenami, Iukary Oliveira
Loureiro, Camila
Machado Junior, Almério
Emodi, Krisztina
Riley, Lee Woodland
Arruda, Sérgio Marcos
author_role author
author2 Loureiro, Camila
Machado Junior, Almério
Emodi, Krisztina
Riley, Lee Woodland
Arruda, Sérgio Marcos
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Takenami, Iukary Oliveira
Loureiro, Camila
Machado Junior, Almério
Emodi, Krisztina
Riley, Lee Woodland
Arruda, Sérgio Marcos
dc.subject.other.pt_BR.fl_str_mv Mycobacterium tuberculosis
Infecção
Teste tuberculínico
Tuberculose pulmonae
topic Mycobacterium tuberculosis
Infecção
Teste tuberculínico
Tuberculose pulmonae
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-11-12T13:58:19Z
dc.date.available.fl_str_mv 2014-11-12T13:58:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TAKENAMI, I. et al. Blood cells and interferon-gamma levels correlation in latent tuberculosis infection. ISRN Pulmonology , p.1-8, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8801
dc.identifier.issn.none.fl_str_mv 2090-5769
dc.identifier.doi.none.fl_str_mv dx.doi.org/10.1155/2013/256148
identifier_str_mv TAKENAMI, I. et al. Blood cells and interferon-gamma levels correlation in latent tuberculosis infection. ISRN Pulmonology , p.1-8, 2013.
2090-5769
dx.doi.org/10.1155/2013/256148
url https://www.arca.fiocruz.br/handle/icict/8801
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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