sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/25633 |
Resumo: | Fundação de Apoio à Pesquisa e à Inovação Tecnológica do Estado de Sergipe (FAPITEC - http://www.fapitec.se.gov.br/)/SE/FUNTEC/Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Grants: CNPq n.12/2009, Processo n. 019.203.02712/2009-8 (ARJ). |
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Silva, Ricardo Luís Louzada daSantos, Marcio BezerraAlmeida, Priscila Lima dos SantosBarros, Thayse SantosMagalhães, Lucas SousaCazzaniga, Rodrigo AnselmoSouza, Patrícia Rodrigues Marques deLuz, Nívea FariasCosta, Jaqueline FrançaBorges, Valeria de MatosLima Junior, Djalma de SouzaLipscomb, Michael WDuthie, Malcolm SReed, Steven GAlmeida, Roque Pacheco deJesus, Amélia Maria Ribeiro de2018-04-05T13:58:17Z2018-04-05T13:58:17Z2017SILVA, R. L. L. et al. sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis. PLoS Neglected Tropical Diseases, v. 11, n. 3, p. e0005486, 2017.1935-2727https://www.arca.fiocruz.br/handle/icict/2563310.1371/journal.pntd.0005486Fundação de Apoio à Pesquisa e à Inovação Tecnológica do Estado de Sergipe (FAPITEC - http://www.fapitec.se.gov.br/)/SE/FUNTEC/Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Grants: CNPq n.12/2009, Processo n. 019.203.02712/2009-8 (ARJ).Universidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, Brasil / Universidade Federal de Sergipe. Departamento de Educação em Saúde de Lagarto. Lagarto, SE, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, Brasil / Universidade Federal de Sergipe. Departamento de Educação em Saúde de Lagarto. Lagarto, SE, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, Brasil / Universidade Federal de Sergipe. Departamento de Educação em Saúde de Lagarto. Lagarto, SE, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, Brasil / Universidade Federal de Sergipe. Departamento de Educação em Saúde de Lagarto. Lagarto, SE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, BrasilHoward University. Department of Biology. Washington, DC, USAInfectious Diseases Research Institute. Seattle, WA, USAInfectious Diseases Research Institute. Seattle, WA, USAUniversidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, BrasilCD163, receptor for the haptoglobin-hemoglobin complex, is expressed on monocytes/macrophages and neutrophils. A soluble form of CD163 (sCD163) has been associated with the M2 macrophage phenotype, and M2 macrophages have been shown to down-modulate inflammatory responses. In particular, previous studies have shown that M2 is closely associated with the most severe clinical presentation of leprosy (i.e. lepromatous leprosy (LL)), as well as tuberculosis. We hypothesized that sCD163 correlates with severity of diseases caused by intracellular pathogens.engPublic Library of ScienceLeishmaniose VisceralLepraBiomarcadoresHumanosLeishmaniasis, VisceralLeprosyBiomarkersHumanssCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25633/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSilva LR sCD163 levels as a biomarker of disease....pdfSilva LR sCD163 levels as a biomarker of disease....pdfapplication/pdf1813439https://www.arca.fiocruz.br/bitstream/icict/25633/2/Silva%20LR%20sCD163%20levels%20as%20a%20biomarker%20of%20disease....pdf61b593e582b8cc501964a9d141747a1aMD52TEXTSilva LR sCD163 levels 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| dc.title.pt_BR.fl_str_mv |
sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis |
| title |
sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis |
| spellingShingle |
sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis Silva, Ricardo Luís Louzada da Leishmaniose Visceral Lepra Biomarcadores Humanos Leishmaniasis, Visceral Leprosy Biomarkers Humans |
| title_short |
sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis |
| title_full |
sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis |
| title_fullStr |
sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis |
| title_full_unstemmed |
sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis |
| title_sort |
sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis |
| author |
Silva, Ricardo Luís Louzada da |
| author_facet |
Silva, Ricardo Luís Louzada da Santos, Marcio Bezerra Almeida, Priscila Lima dos Santos Barros, Thayse Santos Magalhães, Lucas Sousa Cazzaniga, Rodrigo Anselmo Souza, Patrícia Rodrigues Marques de Luz, Nívea Farias Costa, Jaqueline França Borges, Valeria de Matos Lima Junior, Djalma de Souza Lipscomb, Michael W Duthie, Malcolm S Reed, Steven G Almeida, Roque Pacheco de Jesus, Amélia Maria Ribeiro de |
| author_role |
author |
| author2 |
Santos, Marcio Bezerra Almeida, Priscila Lima dos Santos Barros, Thayse Santos Magalhães, Lucas Sousa Cazzaniga, Rodrigo Anselmo Souza, Patrícia Rodrigues Marques de Luz, Nívea Farias Costa, Jaqueline França Borges, Valeria de Matos Lima Junior, Djalma de Souza Lipscomb, Michael W Duthie, Malcolm S Reed, Steven G Almeida, Roque Pacheco de Jesus, Amélia Maria Ribeiro de |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Ricardo Luís Louzada da Santos, Marcio Bezerra Almeida, Priscila Lima dos Santos Barros, Thayse Santos Magalhães, Lucas Sousa Cazzaniga, Rodrigo Anselmo Souza, Patrícia Rodrigues Marques de Luz, Nívea Farias Costa, Jaqueline França Borges, Valeria de Matos Lima Junior, Djalma de Souza Lipscomb, Michael W Duthie, Malcolm S Reed, Steven G Almeida, Roque Pacheco de Jesus, Amélia Maria Ribeiro de |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose Visceral Lepra Biomarcadores Humanos |
| topic |
Leishmaniose Visceral Lepra Biomarcadores Humanos Leishmaniasis, Visceral Leprosy Biomarkers Humans |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmaniasis, Visceral Leprosy Biomarkers Humans |
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Fundação de Apoio à Pesquisa e à Inovação Tecnológica do Estado de Sergipe (FAPITEC - http://www.fapitec.se.gov.br/)/SE/FUNTEC/Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Grants: CNPq n.12/2009, Processo n. 019.203.02712/2009-8 (ARJ). |
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2017 |
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2017 |
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2018-04-05T13:58:17Z |
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2018-04-05T13:58:17Z |
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SILVA, R. L. L. et al. sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis. PLoS Neglected Tropical Diseases, v. 11, n. 3, p. e0005486, 2017. |
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https://www.arca.fiocruz.br/handle/icict/25633 |
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1935-2727 |
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10.1371/journal.pntd.0005486 |
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SILVA, R. L. L. et al. sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis. PLoS Neglected Tropical Diseases, v. 11, n. 3, p. e0005486, 2017. 1935-2727 10.1371/journal.pntd.0005486 |
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