Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
DOI: | 10.3389/fcimb.2018.00245 |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/29466 |
Resumo: | Research Program of the NIH, National Institute of Allergy and Infectious Diseases and by FAPESB (Fundação de Apoio a Pesquisa do Estado da Bahia), grant numbers SUS0036/2013 and PET0024/2013. CB is a senior investigator of the National Council of Research (CNPq). |
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Brodskyn, Claudia IdaKamhawi, Shaden2018-10-09T16:24:08Z2018-10-09T16:24:08Z2018BRODSKYN, C. I.; KAMHAWI, S. Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America. Frontiers in Cellular and Infection Microbiology, v. 8, july 2018.2235-2988https://www.arca.fiocruz.br/handle/icict/2946610.3389/fcimb.2018.00245Research Program of the NIH, National Institute of Allergy and Infectious Diseases and by FAPESB (Fundação de Apoio a Pesquisa do Estado da Bahia), grant numbers SUS0036/2013 and PET0024/2013. CB is a senior investigator of the National Council of Research (CNPq).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Bethesda, MD, USAIn Latin America, zoonotic visceral leishmaniasis (ZVL) arising from infection by L. infantum is primarily transmitted by Lutzomyia longipalpis sand flies. Dogs, which are chronic reservoirs of L. infantum, are considered a significant risk factor for acquisition of ZVL due to their close proximity to humans. In addition, as a vector-borne disease the intensity of exposure to vector sand flies can also enhance the risk of developing ZVL. Traditionally, IFN-γ and IL-10 are considered as the two main cytokines which determine the outcome of visceral leishmaniasis. However, more recently, the literature has demonstrated that different mediators, such as lipid mediators (PGE-2, PGF-2 alfa, LTB-4, resolvins) and other important inflammatory and anti-inflammatory cytokines are also involved in the pathogenicity of ZVL. Analysis of a greater number of mediators allows for a more complete view of disease immunopathogenesis. Additionally, our knowledge has expanded to encompass different biomarkers associated to disease severity and healing after specific treatments. These parameters can also be used to better define new potential targets for vaccines and chemotherapy for ZVL. Here, we will provide an overview of ZVL biomarkers identified for both humans and dogs and discuss their merits and shortcomings. We will also discuss biomarkers of vector exposure as an additional tool in our arsenal to combat ZVL.engFrontiers MediaLeishmaniose visceral zoonóticaLeishmania infantumBiomarcadorescitocinas / quimiocinasCaninaVisceral leishmaniasisZoonotic visceral leishmaniasisLeishmania infantumBiomarkersCytokines/chemokinesCanineHuman visceral leishmaniasisBiomarkers for Zoonotic Visceral Leishmaniasis in Latin Americainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/29466/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBrodskyn CI Biomarkers for zoo...2018.pdfBrodskyn CI Biomarkers for zoo...2018.pdfapplication/pdf296987https://www.arca.fiocruz.br/bitstream/icict/29466/2/Brodskyn%20CI%20Biomarkers%20for%20zoo...2018.pdf4cf370e5a3636813c79517d2fe7ea8d8MD52TEXTBrodskyn CI Biomarkers for zoo...2018.pdf.txtBrodskyn CI Biomarkers for zoo...2018.pdf.txtExtracted texttext/plain60489https://www.arca.fiocruz.br/bitstream/icict/29466/3/Brodskyn%20CI%20Biomarkers%20for%20zoo...2018.pdf.txtd6628a74ab5142b7bb9eebe8b5720381MD53icict/294662023-03-15 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dc.title.pt_BR.fl_str_mv |
Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America |
title |
Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America |
spellingShingle |
Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America Brodskyn, Claudia Ida Leishmaniose visceral zoonótica Leishmania infantum Biomarcadores citocinas / quimiocinas Canina Visceral leishmaniasis Zoonotic visceral leishmaniasis Leishmania infantum Biomarkers Cytokines/chemokines Canine Human visceral leishmaniasis |
title_short |
Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America |
title_full |
Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America |
title_fullStr |
Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America |
title_full_unstemmed |
Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America |
title_sort |
Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America |
author |
Brodskyn, Claudia Ida |
author_facet |
Brodskyn, Claudia Ida Kamhawi, Shaden |
author_role |
author |
author2 |
Kamhawi, Shaden |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Brodskyn, Claudia Ida Kamhawi, Shaden |
dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose visceral zoonótica Leishmania infantum Biomarcadores citocinas / quimiocinas Canina Visceral leishmaniasis |
topic |
Leishmaniose visceral zoonótica Leishmania infantum Biomarcadores citocinas / quimiocinas Canina Visceral leishmaniasis Zoonotic visceral leishmaniasis Leishmania infantum Biomarkers Cytokines/chemokines Canine Human visceral leishmaniasis |
dc.subject.en.pt_BR.fl_str_mv |
Zoonotic visceral leishmaniasis Leishmania infantum Biomarkers Cytokines/chemokines Canine Human visceral leishmaniasis |
description |
Research Program of the NIH, National Institute of Allergy and Infectious Diseases and by FAPESB (Fundação de Apoio a Pesquisa do Estado da Bahia), grant numbers SUS0036/2013 and PET0024/2013. CB is a senior investigator of the National Council of Research (CNPq). |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-10-09T16:24:08Z |
dc.date.available.fl_str_mv |
2018-10-09T16:24:08Z |
dc.date.issued.fl_str_mv |
2018 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BRODSKYN, C. I.; KAMHAWI, S. Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America. Frontiers in Cellular and Infection Microbiology, v. 8, july 2018. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/29466 |
dc.identifier.issn.pt_BR.fl_str_mv |
2235-2988 |
dc.identifier.doi.none.fl_str_mv |
10.3389/fcimb.2018.00245 |
identifier_str_mv |
BRODSKYN, C. I.; KAMHAWI, S. Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America. Frontiers in Cellular and Infection Microbiology, v. 8, july 2018. 2235-2988 10.3389/fcimb.2018.00245 |
url |
https://www.arca.fiocruz.br/handle/icict/29466 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Frontiers Media |
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Frontiers Media |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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