Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America

Detalhes bibliográficos
Autor(a) principal: Brodskyn, Claudia Ida
Data de Publicação: 2018
Outros Autores: Kamhawi, Shaden
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/29466
Resumo: Research Program of the NIH, National Institute of Allergy and Infectious Diseases and by FAPESB (Fundação de Apoio a Pesquisa do Estado da Bahia), grant numbers SUS0036/2013 and PET0024/2013. CB is a senior investigator of the National Council of Research (CNPq).
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spelling Brodskyn, Claudia IdaKamhawi, Shaden2018-10-09T16:24:08Z2018-10-09T16:24:08Z2018BRODSKYN, C. I.; KAMHAWI, S. Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America. Frontiers in Cellular and Infection Microbiology, v. 8, july 2018.2235-2988https://www.arca.fiocruz.br/handle/icict/2946610.3389/fcimb.2018.00245Research Program of the NIH, National Institute of Allergy and Infectious Diseases and by FAPESB (Fundação de Apoio a Pesquisa do Estado da Bahia), grant numbers SUS0036/2013 and PET0024/2013. CB is a senior investigator of the National Council of Research (CNPq).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Bethesda, MD, USAIn Latin America, zoonotic visceral leishmaniasis (ZVL) arising from infection by L. infantum is primarily transmitted by Lutzomyia longipalpis sand flies. Dogs, which are chronic reservoirs of L. infantum, are considered a significant risk factor for acquisition of ZVL due to their close proximity to humans. In addition, as a vector-borne disease the intensity of exposure to vector sand flies can also enhance the risk of developing ZVL. Traditionally, IFN-γ and IL-10 are considered as the two main cytokines which determine the outcome of visceral leishmaniasis. However, more recently, the literature has demonstrated that different mediators, such as lipid mediators (PGE-2, PGF-2 alfa, LTB-4, resolvins) and other important inflammatory and anti-inflammatory cytokines are also involved in the pathogenicity of ZVL. Analysis of a greater number of mediators allows for a more complete view of disease immunopathogenesis. Additionally, our knowledge has expanded to encompass different biomarkers associated to disease severity and healing after specific treatments. These parameters can also be used to better define new potential targets for vaccines and chemotherapy for ZVL. Here, we will provide an overview of ZVL biomarkers identified for both humans and dogs and discuss their merits and shortcomings. We will also discuss biomarkers of vector exposure as an additional tool in our arsenal to combat ZVL.engFrontiers MediaLeishmaniose visceral zoonóticaLeishmania infantumBiomarcadorescitocinas / quimiocinasCaninaVisceral leishmaniasisZoonotic visceral leishmaniasisLeishmania infantumBiomarkersCytokines/chemokinesCanineHuman visceral leishmaniasisBiomarkers for Zoonotic Visceral Leishmaniasis in Latin Americainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/29466/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBrodskyn CI Biomarkers for zoo...2018.pdfBrodskyn CI Biomarkers for 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dc.title.pt_BR.fl_str_mv Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America
title Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America
spellingShingle Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America
Brodskyn, Claudia Ida
Leishmaniose visceral zoonótica
Leishmania infantum
Biomarcadores
citocinas / quimiocinas
Canina
Visceral leishmaniasis
Zoonotic visceral leishmaniasis
Leishmania infantum
Biomarkers
Cytokines/chemokines
Canine
Human visceral leishmaniasis
title_short Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America
title_full Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America
title_fullStr Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America
title_full_unstemmed Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America
title_sort Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America
author Brodskyn, Claudia Ida
author_facet Brodskyn, Claudia Ida
Kamhawi, Shaden
author_role author
author2 Kamhawi, Shaden
author2_role author
dc.contributor.author.fl_str_mv Brodskyn, Claudia Ida
Kamhawi, Shaden
dc.subject.other.pt_BR.fl_str_mv Leishmaniose visceral zoonótica
Leishmania infantum
Biomarcadores
citocinas / quimiocinas
Canina
Visceral leishmaniasis
topic Leishmaniose visceral zoonótica
Leishmania infantum
Biomarcadores
citocinas / quimiocinas
Canina
Visceral leishmaniasis
Zoonotic visceral leishmaniasis
Leishmania infantum
Biomarkers
Cytokines/chemokines
Canine
Human visceral leishmaniasis
dc.subject.en.pt_BR.fl_str_mv Zoonotic visceral leishmaniasis
Leishmania infantum
Biomarkers
Cytokines/chemokines
Canine
Human visceral leishmaniasis
description Research Program of the NIH, National Institute of Allergy and Infectious Diseases and by FAPESB (Fundação de Apoio a Pesquisa do Estado da Bahia), grant numbers SUS0036/2013 and PET0024/2013. CB is a senior investigator of the National Council of Research (CNPq).
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-10-09T16:24:08Z
dc.date.available.fl_str_mv 2018-10-09T16:24:08Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BRODSKYN, C. I.; KAMHAWI, S. Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America. Frontiers in Cellular and Infection Microbiology, v. 8, july 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/29466
dc.identifier.issn.pt_BR.fl_str_mv 2235-2988
dc.identifier.doi.none.fl_str_mv 10.3389/fcimb.2018.00245
identifier_str_mv BRODSKYN, C. I.; KAMHAWI, S. Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America. Frontiers in Cellular and Infection Microbiology, v. 8, july 2018.
2235-2988
10.3389/fcimb.2018.00245
url https://www.arca.fiocruz.br/handle/icict/29466
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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