Molecular Epidemiology of Group A Rotavirus Among Children Admitted to Hospital in Salto, Uruguay, 2011-2012: First Detection of the Emerging Genotype G12
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/12103 |
Resumo: | 2016-04-30 |
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Tort, Luis Fernando LópezVictoria, MatiasLizasoain A, AndrésCastella, MatíasMaya, LeticiaGómez, Mariela MartínezArreseigor, EditLópez, PatriciaCristina, JuanLeite, José Paulo GagliardiColina, Rodney2015-11-03T10:49:09Z2016-05-01T07:30:05Z2015TORT, Luis Fernando López; et al. Molecular Epidemiology of Group A Rotavirus Among Children Admitted to Hospital in Salto, Uruguay, 2011-2012: First Detection of the Emerging Genotype G12. Journal of Medical Virology, v.87, n.5, p.754–763, May 2015.0146-6615https://www.arca.fiocruz.br/handle/icict/1210310.1002/jmv.241231096-9071engWiley Periodicals Inc.CriançasGenótipo GGenótipo PUruguaiGroup A rotavirushospitalized childrenG- and P-genotypesSalto; UruguayRotavirusInfecções por RotavirusGastroenteriteMolecular Epidemiology of Group A Rotavirus Among Children Admitted to Hospital in Salto, Uruguay, 2011-2012: First Detection of the Emerging Genotype G12info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2016-04-30University of Republic. North Regional. Molecular Virology Laboratory. Salto, Uruguay.University of Republic. North Regional. Molecular Virology Laboratory. Salto, Uruguay.University of Republic. North Regional. Molecular Virology Laboratory. Salto, Uruguay.University of Republic. North Regional. Molecular Virology Laboratory. Salto, Uruguay.University of Republic. North Regional. Molecular Virology Laboratory. Salto, Uruguay.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.Medical-Surgical Society. Pediatric Unit.Salto, Uruguay.Pediatric Unit of Regional Public Hospital. Salto, Uruguay.University of Republic. Faculty of Sciences. Molecular Virology Laboratory. Salto, Uruguay.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.University of Republic. North Regional. Molecular Virology Laboratory. Salto, Uruguay.Group A rotavirus (RVA) is the most important etiologic agent of infant acute gastroenteritis (AGE) worldwide. Detection and molecular characterization of RVA in Salto department, Northwestern region of Uruguay, was conducted on 175 clinical samples, being 153 stool and 22 vomit samples, collected from hospitalized children with AGE, between 0–15 years old, from two hospitals of Salto city during 2011 and 2012. RVA was detected and genotyped by seminested multiplex RT-PCR in order to determine G- and P-genotypes. Positive samples were sequenced and phylogenetic analyses were carried out in order to determine lineages and sub-lineages. RVA were detected in 64 (37%) of the samples and the G and P genotypes observed were: 6% G1P[8], 23% G2P[4]/G2P[X]/GXP[4], 23% G3P[8]/G3P[X], 14% G12P[8]/G12P[X], 16% GXP[8], 1,5% G12P- [9], 3% G2P[4]/[8], and 16% non-typeable. VP7 and VP4 genotypes related to DS-1 like gene constellation were prevalent during 2011 and those VP7 and VP4 genotypes related to Walike constellation were prevalent during 2012 (mainly represented by G3P[8]). Interestingly, RVA was detected in vomit samples in a high prevalence (41%). RVA was observed mainly in the age group between 1 and 5 years old (75% of the cases), and seasonality with a high detection rate in winter season was observed for the two consecutive years of surveillance. To our knowledge, this study represents the first detection and molecular characterization of RVA in Salto department, Northwestern region of Uruguay; and the first identification of the emerging genotype G12 in the country.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/12103/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALmariela_gomez_etal_IOC_2015.pdfmariela_gomez_etal_IOC_2015.pdfapplication/pdf595284https://www.arca.fiocruz.br/bitstream/icict/12103/2/mariela_gomez_etal_IOC_2015.pdf70b0af58cd1d663b1b3f4d6522d1187eMD52TEXTmariela_gomez_etal_IOC_2015.pdf.txtmariela_gomez_etal_IOC_2015.pdf.txtExtracted texttext/plain45553https://www.arca.fiocruz.br/bitstream/icict/12103/3/mariela_gomez_etal_IOC_2015.pdf.txtd2f57e26b55b01055e1675bc5de3bbbbMD53icict/121032021-03-24 16:32:18.692oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:18Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Molecular Epidemiology of Group A Rotavirus Among Children Admitted to Hospital in Salto, Uruguay, 2011-2012: First Detection of the Emerging Genotype G12 |
| title |
Molecular Epidemiology of Group A Rotavirus Among Children Admitted to Hospital in Salto, Uruguay, 2011-2012: First Detection of the Emerging Genotype G12 |
| spellingShingle |
Molecular Epidemiology of Group A Rotavirus Among Children Admitted to Hospital in Salto, Uruguay, 2011-2012: First Detection of the Emerging Genotype G12 Tort, Luis Fernando López Crianças Genótipo G Genótipo P Uruguai Group A rotavirus hospitalized children G- and P-genotypes Salto; Uruguay Rotavirus Infecções por Rotavirus Gastroenterite |
| title_short |
Molecular Epidemiology of Group A Rotavirus Among Children Admitted to Hospital in Salto, Uruguay, 2011-2012: First Detection of the Emerging Genotype G12 |
| title_full |
Molecular Epidemiology of Group A Rotavirus Among Children Admitted to Hospital in Salto, Uruguay, 2011-2012: First Detection of the Emerging Genotype G12 |
| title_fullStr |
Molecular Epidemiology of Group A Rotavirus Among Children Admitted to Hospital in Salto, Uruguay, 2011-2012: First Detection of the Emerging Genotype G12 |
| title_full_unstemmed |
Molecular Epidemiology of Group A Rotavirus Among Children Admitted to Hospital in Salto, Uruguay, 2011-2012: First Detection of the Emerging Genotype G12 |
| title_sort |
Molecular Epidemiology of Group A Rotavirus Among Children Admitted to Hospital in Salto, Uruguay, 2011-2012: First Detection of the Emerging Genotype G12 |
| author |
Tort, Luis Fernando López |
| author_facet |
Tort, Luis Fernando López Victoria, Matias Lizasoain A, Andrés Castella, Matías Maya, Leticia Gómez, Mariela Martínez Arreseigor, Edit López, Patricia Cristina, Juan Leite, José Paulo Gagliardi Colina, Rodney |
| author_role |
author |
| author2 |
Victoria, Matias Lizasoain A, Andrés Castella, Matías Maya, Leticia Gómez, Mariela Martínez Arreseigor, Edit López, Patricia Cristina, Juan Leite, José Paulo Gagliardi Colina, Rodney |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Tort, Luis Fernando López Victoria, Matias Lizasoain A, Andrés Castella, Matías Maya, Leticia Gómez, Mariela Martínez Arreseigor, Edit López, Patricia Cristina, Juan Leite, José Paulo Gagliardi Colina, Rodney |
| dc.subject.other.pt_BR.fl_str_mv |
Crianças Genótipo G Genótipo P Uruguai |
| topic |
Crianças Genótipo G Genótipo P Uruguai Group A rotavirus hospitalized children G- and P-genotypes Salto; Uruguay Rotavirus Infecções por Rotavirus Gastroenterite |
| dc.subject.en.pt_BR.fl_str_mv |
Group A rotavirus hospitalized children G- and P-genotypes Salto; Uruguay |
| dc.subject.decs.pt_BR.fl_str_mv |
Rotavirus Infecções por Rotavirus Gastroenterite |
| description |
2016-04-30 |
| publishDate |
2015 |
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2015-11-03T10:49:09Z |
| dc.date.issued.fl_str_mv |
2015 |
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2016-05-01T07:30:05Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
TORT, Luis Fernando López; et al. Molecular Epidemiology of Group A Rotavirus Among Children Admitted to Hospital in Salto, Uruguay, 2011-2012: First Detection of the Emerging Genotype G12. Journal of Medical Virology, v.87, n.5, p.754–763, May 2015. |
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https://www.arca.fiocruz.br/handle/icict/12103 |
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0146-6615 |
| dc.identifier.doi.none.fl_str_mv |
10.1002/jmv.24123 |
| dc.identifier.eissn.none.fl_str_mv |
1096-9071 |
| identifier_str_mv |
TORT, Luis Fernando López; et al. Molecular Epidemiology of Group A Rotavirus Among Children Admitted to Hospital in Salto, Uruguay, 2011-2012: First Detection of the Emerging Genotype G12. Journal of Medical Virology, v.87, n.5, p.754–763, May 2015. 0146-6615 10.1002/jmv.24123 1096-9071 |
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https://www.arca.fiocruz.br/handle/icict/12103 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Wiley Periodicals Inc. |
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Wiley Periodicals Inc. |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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