Epidemiological profile of Zika, Dengue and Chikungunya virus infections identified by medical and molecular evaluations in Rondonia, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/36423 |
Resumo: | Fundação Oswaldo Cruz. Escritório Rondônia. Porto Velho, RO, Brasil / Universidade Federal de Rondônia. Programa de Pós-Graduação em Biologia Experimental. Porto Velho, RO, Brasil / Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil. |
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Vieira, Deusilene SouzaZambenedetti, Miriam RibasRequião, LucianaBorghetti, Ivo AlbertoLuna, Luciano Kleber de SouzaSantos, Alcione de Oliveira dosTaborda, Roger Lafontaine MesquitaPereira, Dhelio BatistaKrieger, Marco AurélioSalcedo, Juan Miguel VillalobosRampazzo, Rita de Cássia Pontello2019-10-14T18:40:24Z2019-10-14T18:40:24Z2019VIEIRA, Deusilene Souza et al. Epidemiological profile of Zika, Dengue and Chikungunya virus infections identified by medical and molecular evaluations in Rondonia, Brazil. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo. v. 61, n. 40, p. 1-62, 2019.0036-4665https://www.arca.fiocruz.br/handle/icict/3642310.1590/S1678-99462019610401678-9946porUniversidade de São PauloDengueZika VirusChikungunya virusReal-Time Polymerase Chain ReactionArbovirus InfectionsPathology, MolecularVirus ZikaVirus ChikungunyaReacción en Cadena en Tiempo Real de la PolimerasaInfecciones por ArbovirusPatología MolecularZika virusVírus ChikungunyaReação em Cadeia da Polimerase em Tempo RealInfecções por ArbovirusPatologia MolecularEpidemiological profile of Zika, Dengue and Chikungunya virus infections identified by medical and molecular evaluations in Rondonia, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Escritório Rondônia. Porto Velho, RO, Brasil / Universidade Federal de Rondônia. Programa de Pós-Graduação em Biologia Experimental. Porto Velho, RO, Brasil / Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil.Instituto de Biologia Molecular do Paraná. Curitiba, PR, Brasil.Instituto de Biologia Molecular do Paraná. Curitiba, PR, Brasil.Instituto de Biologia Molecular do Paraná. Curitiba, PR, Brasil / Universidade Federal do Paraná. Departamento de Engenharia de Bioprocessos e Biotecnologia. Curitiba, PR, Brasil.Instituto de Biologia Molecular do Paraná. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Escritório Rondônia. Porto Velho, RO, Brasil / Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil.Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil.Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil.Instituto de Biologia Molecular do Paraná. Curitiba, PR, Brasil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Escritório Rondônia. Porto Velho, RO, Brasil / Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil.Instituto de Biologia Molecular do Paraná. Curitiba, PR, Brasil.Several arboviruses have emerged and/or re-emerged in North, Central and South-American countries. Viruses from some regions of Africa and Asia, such as the Zika and Chikungunya virus have been introduced in new continents causing major public health problems. The aim of this study was to investigate the presence of RNA from Zika, Dengue and Chikungunya viruses in symptomatic patients from Rondonia, where the epidemiological profile is still little known, by one-step real-time RT-PCR. The main clinical signs and symtoms were fever (51.2%), headache (78%), chills (6.1%), pruritus (12.2%), exanthema (20.1%), arthralgia (35.3%), myalgia (26.8%) and retro-orbital pain (19.5%). Serum from 164 symptomatic patients were collected and tested for RNA of Zika, Dengue types 1 to 4 and Chikungunya viruses, in addition to antibodies against Dengue NS1 antigen. Direct microscopy for Malaria was also performed. Only ZIKV RNA was detected in 4.3% of the patients, and in the remaining 95.7% of the patients RNA for Zika, Dengue and Chikungunya viruses were not detected. This finding is intriguing as the region has been endemic for Dengue for a long time and more recently for Chikungunya virus as well. The results indicated that medical and molecular parameters obtained were suitable to describe the first report of symptomatic Zika infections in this region. Furthermore, the low rate of detection, compared to clinical signs and symptoms as the solely diagnosis criteria, suggests that molecular assays for detection of viruses or other pathogens that cause similar symptoms should be used and the corresponding diseases could be included in the compulsory notification list.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/36423/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINAL1678-9946-rimtsp-6.pdf1678-9946-rimtsp-6.pdfapplication/pdf697331https://www.arca.fiocruz.br/bitstream/icict/36423/2/1678-9946-rimtsp-6.pdf763768a7ff5bd025725e445bd0dacd7dMD52TEXT1678-9946-rimtsp-6.pdf.txt1678-9946-rimtsp-6.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Epidemiological profile of Zika, Dengue and Chikungunya virus infections identified by medical and molecular evaluations in Rondonia, Brazil |
| title |
Epidemiological profile of Zika, Dengue and Chikungunya virus infections identified by medical and molecular evaluations in Rondonia, Brazil |
| spellingShingle |
Epidemiological profile of Zika, Dengue and Chikungunya virus infections identified by medical and molecular evaluations in Rondonia, Brazil Vieira, Deusilene Souza Dengue Zika Virus Chikungunya virus Real-Time Polymerase Chain Reaction Arbovirus Infections Pathology, Molecular Virus Zika Virus Chikungunya Reacción en Cadena en Tiempo Real de la Polimerasa Infecciones por Arbovirus Patología Molecular Zika virus Vírus Chikungunya Reação em Cadeia da Polimerase em Tempo Real Infecções por Arbovirus Patologia Molecular |
| title_short |
Epidemiological profile of Zika, Dengue and Chikungunya virus infections identified by medical and molecular evaluations in Rondonia, Brazil |
| title_full |
Epidemiological profile of Zika, Dengue and Chikungunya virus infections identified by medical and molecular evaluations in Rondonia, Brazil |
| title_fullStr |
Epidemiological profile of Zika, Dengue and Chikungunya virus infections identified by medical and molecular evaluations in Rondonia, Brazil |
| title_full_unstemmed |
Epidemiological profile of Zika, Dengue and Chikungunya virus infections identified by medical and molecular evaluations in Rondonia, Brazil |
| title_sort |
Epidemiological profile of Zika, Dengue and Chikungunya virus infections identified by medical and molecular evaluations in Rondonia, Brazil |
| author |
Vieira, Deusilene Souza |
| author_facet |
Vieira, Deusilene Souza Zambenedetti, Miriam Ribas Requião, Luciana Borghetti, Ivo Alberto Luna, Luciano Kleber de Souza Santos, Alcione de Oliveira dos Taborda, Roger Lafontaine Mesquita Pereira, Dhelio Batista Krieger, Marco Aurélio Salcedo, Juan Miguel Villalobos Rampazzo, Rita de Cássia Pontello |
| author_role |
author |
| author2 |
Zambenedetti, Miriam Ribas Requião, Luciana Borghetti, Ivo Alberto Luna, Luciano Kleber de Souza Santos, Alcione de Oliveira dos Taborda, Roger Lafontaine Mesquita Pereira, Dhelio Batista Krieger, Marco Aurélio Salcedo, Juan Miguel Villalobos Rampazzo, Rita de Cássia Pontello |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Vieira, Deusilene Souza Zambenedetti, Miriam Ribas Requião, Luciana Borghetti, Ivo Alberto Luna, Luciano Kleber de Souza Santos, Alcione de Oliveira dos Taborda, Roger Lafontaine Mesquita Pereira, Dhelio Batista Krieger, Marco Aurélio Salcedo, Juan Miguel Villalobos Rampazzo, Rita de Cássia Pontello |
| dc.subject.other.pt_BR.fl_str_mv |
Dengue |
| topic |
Dengue Zika Virus Chikungunya virus Real-Time Polymerase Chain Reaction Arbovirus Infections Pathology, Molecular Virus Zika Virus Chikungunya Reacción en Cadena en Tiempo Real de la Polimerasa Infecciones por Arbovirus Patología Molecular Zika virus Vírus Chikungunya Reação em Cadeia da Polimerase em Tempo Real Infecções por Arbovirus Patologia Molecular |
| dc.subject.en.pt_BR.fl_str_mv |
Zika Virus Chikungunya virus Real-Time Polymerase Chain Reaction Arbovirus Infections Pathology, Molecular |
| dc.subject.es.pt_BR.fl_str_mv |
Virus Zika Virus Chikungunya Reacción en Cadena en Tiempo Real de la Polimerasa Infecciones por Arbovirus Patología Molecular |
| dc.subject.decs.pt_BR.fl_str_mv |
Zika virus Vírus Chikungunya Reação em Cadeia da Polimerase em Tempo Real Infecções por Arbovirus Patologia Molecular |
| description |
Fundação Oswaldo Cruz. Escritório Rondônia. Porto Velho, RO, Brasil / Universidade Federal de Rondônia. Programa de Pós-Graduação em Biologia Experimental. Porto Velho, RO, Brasil / Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil. |
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2019 |
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2019-10-14T18:40:24Z |
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2019-10-14T18:40:24Z |
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2019 |
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VIEIRA, Deusilene Souza et al. Epidemiological profile of Zika, Dengue and Chikungunya virus infections identified by medical and molecular evaluations in Rondonia, Brazil. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo. v. 61, n. 40, p. 1-62, 2019. |
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https://www.arca.fiocruz.br/handle/icict/36423 |
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0036-4665 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/S1678-9946201961040 |
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1678-9946 |
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VIEIRA, Deusilene Souza et al. Epidemiological profile of Zika, Dengue and Chikungunya virus infections identified by medical and molecular evaluations in Rondonia, Brazil. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo. v. 61, n. 40, p. 1-62, 2019. 0036-4665 10.1590/S1678-9946201961040 1678-9946 |
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Universidade de São Paulo |
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Universidade de São Paulo |
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