Reactive Oxygen Species Scavenging by Catalase Is Important for Female Lutzomyia longipalpis Fecundity and Mortality

Detalhes bibliográficos
Autor(a) principal: Diaz-Albiter, Hector
Data de Publicação: 2011
Outros Autores: Mitford, Roanna, Genta, Fernando A., Sant´Anna, Mauricio R. V., Dillon, Rod J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30040
Resumo: Liverpool School of Tropical Medicine, Vector Group. Liverpool. United Kingdom.
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spelling Diaz-Albiter, HectorMitford, RoannaGenta, Fernando A.Sant´Anna, Mauricio R. V.Dillon, Rod J.2018-11-15T13:56:23Z2018-11-15T13:56:23Z2011DIAZ-ALBITER, Hector; et al. Reactive Oxygen Species Scavenging by Catalase Is Important for Female Lutzomyia Longipalpis Fecundity and Mortality. Plos One, v.6, n.3, e17486, 9p, Mar. 2011.1932-6203https://www.arca.fiocruz.br/handle/icict/3004010.1371/journal.pone.0017486engPublic Library of ScienceLutzomyia LongipalpisFêmeasEspécies reativas de oxigênioCatalaseFecundidadeMortalidadeLutzomyia LongipalpisReactive Oxygen SpeciesCatalaseFemaleMortalityFecundityReactive Oxygen Species Scavenging by Catalase Is Important for Female Lutzomyia longipalpis Fecundity and Mortalityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLiverpool School of Tropical Medicine, Vector Group. Liverpool. United Kingdom.Liverpool School of Tropical Medicine, Vector Group. Liverpool. United Kingdom.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia – Entomologia Molecular. Rio de Janeiro, RJ, Brasil.Liverpool School of Tropical Medicine, Vector Group. Liverpool. United Kingdom.Liverpool School of Tropical Medicine, Vector Group. Liverpool. United Kingdom.The phlebotomine sand fly Lutzomyia longipalpis is the most important vector of American visceral leishmaniasis (AVL), the disseminated and most serious form of the disease in Central and South America. In the natural environment, most female L. longipalpis are thought to survive for less than 10 days and will feed on blood only once or twice during their lifetime. Successful transmission of parasites occurs when a Leishmania-infected female sand fly feeds on a new host. Knowledge of factors affecting sand fly longevity that lead to a reduction in lifespan could result in a decrease in parasite transmission. Catalase has been found to play a major role in survival and fecundity in many insect species. It is a strong antioxidant enzyme that breaks down toxic reactive oxygen species (ROS). Ovarian catalase was found to accumulate in the developing sand fly oocyte from 12 to 48 hours after blood feeding. Catalase expression in ovaries as well as oocyte numbers was found to decrease with age. This reduction was not found in flies when fed on the antioxidant ascorbic acid in the sugar meal, a condition that increased mortality and activation of the prophenoloxidase cascade. RNA interference was used to silence catalase gene expression in female Lu. longipalpis. Depletion of catalase led to a significant increase of mortality and a reduction in the number of developing oocytes produced after blood feeding. These results demonstrate the central role that catalase and ROS play in the longevity and fecundity of phlebotomine sand flies.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30040/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALfernandoA_genta_etal_IOC_2011.pdffernandoA_genta_etal_IOC_2011.pdfapplication/pdf684773https://www.arca.fiocruz.br/bitstream/icict/30040/2/fernandoA_genta_etal_IOC_2011.pdfd8f5d3cf9428c3f90e9c21b369d5e438MD52TEXTfernandoA_genta_etal_IOC_2011.pdf.txtfernandoA_genta_etal_IOC_2011.pdf.txtExtracted texttext/plain50959https://www.arca.fiocruz.br/bitstream/icict/30040/3/fernandoA_genta_etal_IOC_2011.pdf.txtcb0c33baea6b6cfb953f40c2ff94006eMD53icict/300402018-11-16 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dc.title.pt_BR.fl_str_mv Reactive Oxygen Species Scavenging by Catalase Is Important for Female Lutzomyia longipalpis Fecundity and Mortality
title Reactive Oxygen Species Scavenging by Catalase Is Important for Female Lutzomyia longipalpis Fecundity and Mortality
spellingShingle Reactive Oxygen Species Scavenging by Catalase Is Important for Female Lutzomyia longipalpis Fecundity and Mortality
Diaz-Albiter, Hector
Lutzomyia Longipalpis
Fêmeas
Espécies reativas de oxigênio
Catalase
Fecundidade
Mortalidade
Lutzomyia Longipalpis
Reactive Oxygen Species
Catalase
Female
Mortality
Fecundity
title_short Reactive Oxygen Species Scavenging by Catalase Is Important for Female Lutzomyia longipalpis Fecundity and Mortality
title_full Reactive Oxygen Species Scavenging by Catalase Is Important for Female Lutzomyia longipalpis Fecundity and Mortality
title_fullStr Reactive Oxygen Species Scavenging by Catalase Is Important for Female Lutzomyia longipalpis Fecundity and Mortality
title_full_unstemmed Reactive Oxygen Species Scavenging by Catalase Is Important for Female Lutzomyia longipalpis Fecundity and Mortality
title_sort Reactive Oxygen Species Scavenging by Catalase Is Important for Female Lutzomyia longipalpis Fecundity and Mortality
author Diaz-Albiter, Hector
author_facet Diaz-Albiter, Hector
Mitford, Roanna
Genta, Fernando A.
Sant´Anna, Mauricio R. V.
Dillon, Rod J.
author_role author
author2 Mitford, Roanna
Genta, Fernando A.
Sant´Anna, Mauricio R. V.
Dillon, Rod J.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Diaz-Albiter, Hector
Mitford, Roanna
Genta, Fernando A.
Sant´Anna, Mauricio R. V.
Dillon, Rod J.
dc.subject.other.pt_BR.fl_str_mv Lutzomyia Longipalpis
Fêmeas
Espécies reativas de oxigênio
Catalase
Fecundidade
Mortalidade
topic Lutzomyia Longipalpis
Fêmeas
Espécies reativas de oxigênio
Catalase
Fecundidade
Mortalidade
Lutzomyia Longipalpis
Reactive Oxygen Species
Catalase
Female
Mortality
Fecundity
dc.subject.en.pt_BR.fl_str_mv Lutzomyia Longipalpis
Reactive Oxygen Species
Catalase
Female
Mortality
Fecundity
description Liverpool School of Tropical Medicine, Vector Group. Liverpool. United Kingdom.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2018-11-15T13:56:23Z
dc.date.available.fl_str_mv 2018-11-15T13:56:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DIAZ-ALBITER, Hector; et al. Reactive Oxygen Species Scavenging by Catalase Is Important for Female Lutzomyia Longipalpis Fecundity and Mortality. Plos One, v.6, n.3, e17486, 9p, Mar. 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30040
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0017486
identifier_str_mv DIAZ-ALBITER, Hector; et al. Reactive Oxygen Species Scavenging by Catalase Is Important for Female Lutzomyia Longipalpis Fecundity and Mortality. Plos One, v.6, n.3, e17486, 9p, Mar. 2011.
1932-6203
10.1371/journal.pone.0017486
url https://www.arca.fiocruz.br/handle/icict/30040
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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