BALB/c mice infected with DENV-2 strain 66985 by the intravenous route display injury in the central nervous system
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/28470 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil. |
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Salomão, Natália G.Rabelo, KíssilaPóvoa, Tiago F.Alves, Ada M. B.Costa, Simone M. daGonçalves, Antônio J. S.Amorim, Juliana F.Azevedo, Adriana S.Nunes, Priscilla C. G.Oliveira, Carlos A. Basílio deOliveira, Rodrigo P. Basílio deGeraldo, Luiz H. M.Fonseca, Celina G.Lima, Flávia R. S.Borges, Ronaldo MohanaSilva, Emiliana M.Santos, Flávia B. dosOliveira, Edson R. A.Paes, Marciano V.2018-08-30T14:19:21Z2018-08-30T14:19:21Z2018SALOMAO, Natália G. et al. BALB/c mice infected with DENV-2 strain 66985 by the intravenous route display injury in the central nervous system. Scientific Reports, v.8:9754, 13p, June 2018.2045-2322https://www.arca.fiocruz.br/handle/icict/2847010.1038/s41598-018-28137-yengNature Publishing GroupDengueSistema nervoso centralVírus da DengueCamundongosInfecçãovia intravenosaDengueCentral nervous systemDengue virusDENV-2 strain 66985Miceintravenous routeBALB/c mice infected with DENV-2 strain 66985 by the intravenous route display injury in the central nervous systeminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.Universidade do Estado do Rio de Janeiro. Laboratório de Ultraestrutura e Biologia Tecidual. Rio de Janeiro, RJ, Brasil.Instituto de Criminalística. Tocantins, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biotecnologia e Fisiologia de Infecções Virais. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biotecnologia e Fisiologia de Infecções Virais. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Tecnologia Virológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Tecnologia Virológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffreé Guinle. Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffreé Guinle. Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Laboratório de Biologia das Células Gliais. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Laboratório de Biologia das Células Gliais. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Laboratório de Biologia das Células Gliais. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Genômica Estrutural. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Genômica Estrutural. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil .Universidade Federal do Rio de Janeiro. Instituto de Química Orgânica. Laboratório de Modelagem Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.Dengue is a mild flu-like arboviral illness caused by dengue virus (DENV) that occurs in tropical and subtropical countries. An increasing number of reports have been indicating that dengue is also associated to neurological manifestations, however, little is known regarding the neuropathogenesis of the disease. Here, using BALB/c mice intravenously infected with DENV-2 strain 66985, we demonstrated that the virus is capable of invading and damaging the host's central nervous system (CNS). Brain and cerebellum of infected animals revealed histological alterations such as the presence of inflammatory infiltrates, thickening of pia matter and disorganization of white matter. Additionally, it was also seen that infection lead to altered morphology of neuroglial cells and apoptotic cell death. Such observations highlighted possible alterations that DENV may promote in the host's CNS during a natural infection, hence, helping us to better understand the neuropathological component of the disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28470/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALnatalia_salomao_etal_ IOC_2018.pdfnatalia_salomao_etal_ IOC_2018.pdfapplication/pdf7390627https://www.arca.fiocruz.br/bitstream/icict/28470/2/natalia_salomao_etal_%20IOC_2018.pdfa29e9822fd304910c185bf4155b70985MD52TEXTnatalia_salomao_etal_ IOC_2018.pdf.txtnatalia_salomao_etal_ IOC_2018.pdf.txtExtracted texttext/plain59152https://www.arca.fiocruz.br/bitstream/icict/28470/3/natalia_salomao_etal_%20IOC_2018.pdf.txt6b56cd5d4ddbdb3b5f70f734fbd95863MD53icict/284702018-08-31 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| dc.title.pt_BR.fl_str_mv |
BALB/c mice infected with DENV-2 strain 66985 by the intravenous route display injury in the central nervous system |
| title |
BALB/c mice infected with DENV-2 strain 66985 by the intravenous route display injury in the central nervous system |
| spellingShingle |
BALB/c mice infected with DENV-2 strain 66985 by the intravenous route display injury in the central nervous system Salomão, Natália G. Dengue Sistema nervoso central Vírus da Dengue Camundongos Infecção via intravenosa Dengue Central nervous system Dengue virus DENV-2 strain 66985 Mice intravenous route |
| title_short |
BALB/c mice infected with DENV-2 strain 66985 by the intravenous route display injury in the central nervous system |
| title_full |
BALB/c mice infected with DENV-2 strain 66985 by the intravenous route display injury in the central nervous system |
| title_fullStr |
BALB/c mice infected with DENV-2 strain 66985 by the intravenous route display injury in the central nervous system |
| title_full_unstemmed |
BALB/c mice infected with DENV-2 strain 66985 by the intravenous route display injury in the central nervous system |
| title_sort |
BALB/c mice infected with DENV-2 strain 66985 by the intravenous route display injury in the central nervous system |
| author |
Salomão, Natália G. |
| author_facet |
Salomão, Natália G. Rabelo, Kíssila Póvoa, Tiago F. Alves, Ada M. B. Costa, Simone M. da Gonçalves, Antônio J. S. Amorim, Juliana F. Azevedo, Adriana S. Nunes, Priscilla C. G. Oliveira, Carlos A. Basílio de Oliveira, Rodrigo P. Basílio de Geraldo, Luiz H. M. Fonseca, Celina G. Lima, Flávia R. S. Borges, Ronaldo Mohana Silva, Emiliana M. Santos, Flávia B. dos Oliveira, Edson R. A. Paes, Marciano V. |
| author_role |
author |
| author2 |
Rabelo, Kíssila Póvoa, Tiago F. Alves, Ada M. B. Costa, Simone M. da Gonçalves, Antônio J. S. Amorim, Juliana F. Azevedo, Adriana S. Nunes, Priscilla C. G. Oliveira, Carlos A. Basílio de Oliveira, Rodrigo P. Basílio de Geraldo, Luiz H. M. Fonseca, Celina G. Lima, Flávia R. S. Borges, Ronaldo Mohana Silva, Emiliana M. Santos, Flávia B. dos Oliveira, Edson R. A. Paes, Marciano V. |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Salomão, Natália G. Rabelo, Kíssila Póvoa, Tiago F. Alves, Ada M. B. Costa, Simone M. da Gonçalves, Antônio J. S. Amorim, Juliana F. Azevedo, Adriana S. Nunes, Priscilla C. G. Oliveira, Carlos A. Basílio de Oliveira, Rodrigo P. Basílio de Geraldo, Luiz H. M. Fonseca, Celina G. Lima, Flávia R. S. Borges, Ronaldo Mohana Silva, Emiliana M. Santos, Flávia B. dos Oliveira, Edson R. A. Paes, Marciano V. |
| dc.subject.other.pt_BR.fl_str_mv |
Dengue Sistema nervoso central Vírus da Dengue Camundongos Infecção via intravenosa |
| topic |
Dengue Sistema nervoso central Vírus da Dengue Camundongos Infecção via intravenosa Dengue Central nervous system Dengue virus DENV-2 strain 66985 Mice intravenous route |
| dc.subject.en.pt_BR.fl_str_mv |
Dengue Central nervous system Dengue virus DENV-2 strain 66985 Mice intravenous route |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil. |
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2018 |
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2018-08-30T14:19:21Z |
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2018-08-30T14:19:21Z |
| dc.date.issued.fl_str_mv |
2018 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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SALOMAO, Natália G. et al. BALB/c mice infected with DENV-2 strain 66985 by the intravenous route display injury in the central nervous system. Scientific Reports, v.8:9754, 13p, June 2018. |
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https://www.arca.fiocruz.br/handle/icict/28470 |
| dc.identifier.issn.pt_BR.fl_str_mv |
2045-2322 |
| dc.identifier.eissn.none.fl_str_mv |
10.1038/s41598-018-28137-y |
| identifier_str_mv |
SALOMAO, Natália G. et al. BALB/c mice infected with DENV-2 strain 66985 by the intravenous route display injury in the central nervous system. Scientific Reports, v.8:9754, 13p, June 2018. 2045-2322 10.1038/s41598-018-28137-y |
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openAccess |
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Nature Publishing Group |
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Nature Publishing Group |
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