Serum Soluble Mediator Profiles and Networks During Acute Infection With Distinct DENV Serotypes
| Autor(a) principal: | |
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| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/54092 |
Resumo: | Instituto Evandro Chagas. Departamento de Arboviroses e Febres Hemorrágicas. Ananindeua, PA, Brasil. |
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Silva, Mikelly Santos Coutinho daSucupira, Pedro Henrique FerreiraBicalho, Kelly AlvesAzevedo, Ana Carolina CampiSouza, Joaquim Pedro Brito dePeruhype-Magalhães, VanessaRios, MariaCarvalho, Andrea TeixeiraReis, Jordana Grazziela Alves Coelho dosAntonelli, Lis Ribeiro do ValleRezende, Vitor Bortolo deMelo, Fernanda Ludolf Ribeiro deGarcia, Cristiana CoutoAndrade, Jesuanne Carla SilvaRocha, Ismael Artur da CostaBastos, Michele de SouzaRocha, Lucia Alves daSilva, Valderjane AprigioFerreira, Ewerton da SilvaMarinho, Eveny Perlize MeloCosta, Allyson GuimarãesGomes, Matheus de SouzaAmaral, Laurence RodriguesFurtado, Erilene Cristina da SilvaSilva, Eliana Vieira Pinto daRamos, Bruna AlvesSantos, Éder Barros dosFreitas, Maria Nazaré OliveiraVasconcelos, Pedro Fernando da CostaMartins Filho, Olindo AssisAraújo, Márcio Sobreira SilvaFerreira, Milene SilveiraMartins, Livia Carício2022-08-01T11:57:25Z2022-08-01T11:57:25Z2022SILVA, Mikelly Santos Coutinho da et al. Serum Soluble Mediator Profiles and Networks During Acute Infection With Distinct DENV Serotypes. Frontiers in Immunology, v. 13, Article 892990, p. 1 - 12, May 2022.1664-3224https://www.arca.fiocruz.br/handle/icict/5409210.3389/fimmu.2022.892990engFrontiers MediaInfecção por dengueVírus da dengueResposta imuneSorotipos DENVQuimiocinasCitocinasDengue infectionDengue virusImmune responseDENV serotypesChemokinesCytokinesSerum Soluble Mediator Profiles and Networks During Acute Infection With Distinct DENV Serotypesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto Evandro Chagas. Departamento de Arboviroses e Febres Hemorrágicas. Ananindeua, PA, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Office of Blood Research and Review (OBRR), Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration (FDA), Silver Spring, MD, USA..Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte. MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Faculdade de Medicina. elo Horizonte, MG, Brasil..Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e Sarampo,. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus , AM, Brasil / Universidade Federal do Amazonas. Escola de Enfermagem de Manaus. Manaus, AM, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manausm AM, Brasil / Universidade Federal do Amazonas. Escola de Enfermagem de Manaus. Manaus, AM, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus , AM, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus , AM, Brasil.Universidade Federal do Amazonas. Escola de Enfermagem de Manaus. Manaus, AM, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manausm AM, Brasil / Universidade Federal do Amazonas. Escola de Enfermagem de Manaus. Manaus, AM, Brasil / Fundac¸ão Hospitalar de Hematologia e Hemoterapia do Amazonas (HEMOAM). Diretoria de Ensino e Pesquisa. Manaus, AM, Brasil.Universidade Federal de Uberlândia. Rede Multidisciplinar de Pesquisa, Ciência e Tecnologia. Laboratório de Bioinformática e Aná lises Moleculares.. Pato de Minas, MG, Brasil.Universidade Federal de Uberlândia. Rede Multidisciplinar de Pesquisa, Ciência e Tecnologia. Laboratório de Bioinformática e Aná lises Moleculares.. Pato de Minas, MG, Brasil.Instituto Evandro Chagas. Departamento de Arboviroses e Febres Hemorrágicas. Ananindeua, PA, Brasil.Instituto Evandro Chagas. Departamento de Arboviroses e Febres Hemorrágicas. Ananindeua, PA, Brasil.Instituto Evandro Chagas. Departamento de Arboviroses e Febres Hemorrágicas. Ananindeua, PA, Brasil.Instituto Evandro Chagas. Departamento de Arboviroses e Febres Hemorrágicas. Ananindeua, PA, Brasil.SILVA,Instituto Evandro Chagas. Departamento de Arboviroses e Febres Hemorrágicas. Ananindeua, PA, Brasil.Instituto Evandro Chagas. Departamento de Arboviroses e Febres Hemorrágicas. Ananindeua, PA, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Instituto Evandro Chagas. Departamento de Arboviroses e Febres Hemorrágicas. Ananindeua, PA, Brasil.Instituto Evandro Chagas. Departamento de Arboviroses e Febres Hemorrágicas. Ananindeua, PA, Brasil.A panoramic analysis of chemokines, pro-inflammatory/regulatory cytokines, and growth factors was performed in serum samples from patients with acute DENV infection (n=317) by a high-throughput microbeads array. Most soluble mediators analyzed were increased in DENV patients regardless of the DENV serotype. The substantial increase (≥10-fold) of CXCL10, IL-6, and IFN-g, and decreased levels of PDGF (<0.4-fold) was universally identified in all DENV serotypes. Of note, increased levels of CXCL8, CCL4, and IL-12 (≥3- 9-fold) were selectively observed in DENV2 as compared to DENV1 and DENV4. Heatmap and biomarker signatures further illustrated the massive release of soluble mediators observed in DENV patients, confirming the marked increase of several soluble mediators in DENV2. Integrative correlation matrices and networks showed that DENV infection exhibited higher connectivity among soluble mediators. Of note, DENV2 displayed a more complex network, with higher connectivity involving a higher number of soluble mediators. The timeline kinetics (Day 0-1, D2, D3, D4-6) analysis additionally demonstrated differences among DENV serotypes. While DENV1 triggers a progressive increase of soluble mediators towards D3 and with a decline at D4-6, DENV2 and DENV4 develop with a progressive increase towards D4-6 with an early plateau observed in DENV4. Overall, our results provided a comprehensive overview of the immune response elicited by DENV infection, revealing that infection with distinct DENV serotypes causes distinct profiles, rhythms, and dynamic network connectivity of soluble mediators. Altogether, these findings may provide novel insights to understand the pathogenesis of acute infection with distinct DENV serotypes.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/54092/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCristianaCoutoGarcia_etal_IOC_2022.pdfCristianaCoutoGarcia_etal_IOC_2022.pdfapplication/pdf9645359https://www.arca.fiocruz.br/bitstream/icict/54092/2/CristianaCoutoGarcia_etal_IOC_2022.pdf626c79ba63f53ab62a12d427d6a97383MD52icict/540922022-08-01 08:57:25.855oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-08-01T11:57:25Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Serum Soluble Mediator Profiles and Networks During Acute Infection With Distinct DENV Serotypes |
| title |
Serum Soluble Mediator Profiles and Networks During Acute Infection With Distinct DENV Serotypes |
| spellingShingle |
Serum Soluble Mediator Profiles and Networks During Acute Infection With Distinct DENV Serotypes Silva, Mikelly Santos Coutinho da Infecção por dengue Vírus da dengue Resposta imune Sorotipos DENV Quimiocinas Citocinas Dengue infection Dengue virus Immune response DENV serotypes Chemokines Cytokines |
| title_short |
Serum Soluble Mediator Profiles and Networks During Acute Infection With Distinct DENV Serotypes |
| title_full |
Serum Soluble Mediator Profiles and Networks During Acute Infection With Distinct DENV Serotypes |
| title_fullStr |
Serum Soluble Mediator Profiles and Networks During Acute Infection With Distinct DENV Serotypes |
| title_full_unstemmed |
Serum Soluble Mediator Profiles and Networks During Acute Infection With Distinct DENV Serotypes |
| title_sort |
Serum Soluble Mediator Profiles and Networks During Acute Infection With Distinct DENV Serotypes |
| author |
Silva, Mikelly Santos Coutinho da |
| author_facet |
Silva, Mikelly Santos Coutinho da Sucupira, Pedro Henrique Ferreira Bicalho, Kelly Alves Azevedo, Ana Carolina Campi Souza, Joaquim Pedro Brito de Peruhype-Magalhães, Vanessa Rios, Maria Carvalho, Andrea Teixeira Reis, Jordana Grazziela Alves Coelho dos Antonelli, Lis Ribeiro do Valle Rezende, Vitor Bortolo de Melo, Fernanda Ludolf Ribeiro de Garcia, Cristiana Couto Andrade, Jesuanne Carla Silva Rocha, Ismael Artur da Costa Bastos, Michele de Souza Rocha, Lucia Alves da Silva, Valderjane Aprigio Ferreira, Ewerton da Silva Marinho, Eveny Perlize Melo Costa, Allyson Guimarães Gomes, Matheus de Souza Amaral, Laurence Rodrigues Furtado, Erilene Cristina da Silva Silva, Eliana Vieira Pinto da Ramos, Bruna Alves Santos, Éder Barros dos Freitas, Maria Nazaré Oliveira Vasconcelos, Pedro Fernando da Costa Martins Filho, Olindo Assis Araújo, Márcio Sobreira Silva Ferreira, Milene Silveira Martins, Livia Carício |
| author_role |
author |
| author2 |
Sucupira, Pedro Henrique Ferreira Bicalho, Kelly Alves Azevedo, Ana Carolina Campi Souza, Joaquim Pedro Brito de Peruhype-Magalhães, Vanessa Rios, Maria Carvalho, Andrea Teixeira Reis, Jordana Grazziela Alves Coelho dos Antonelli, Lis Ribeiro do Valle Rezende, Vitor Bortolo de Melo, Fernanda Ludolf Ribeiro de Garcia, Cristiana Couto Andrade, Jesuanne Carla Silva Rocha, Ismael Artur da Costa Bastos, Michele de Souza Rocha, Lucia Alves da Silva, Valderjane Aprigio Ferreira, Ewerton da Silva Marinho, Eveny Perlize Melo Costa, Allyson Guimarães Gomes, Matheus de Souza Amaral, Laurence Rodrigues Furtado, Erilene Cristina da Silva Silva, Eliana Vieira Pinto da Ramos, Bruna Alves Santos, Éder Barros dos Freitas, Maria Nazaré Oliveira Vasconcelos, Pedro Fernando da Costa Martins Filho, Olindo Assis Araújo, Márcio Sobreira Silva Ferreira, Milene Silveira Martins, Livia Carício |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Mikelly Santos Coutinho da Sucupira, Pedro Henrique Ferreira Bicalho, Kelly Alves Azevedo, Ana Carolina Campi Souza, Joaquim Pedro Brito de Peruhype-Magalhães, Vanessa Rios, Maria Carvalho, Andrea Teixeira Reis, Jordana Grazziela Alves Coelho dos Antonelli, Lis Ribeiro do Valle Rezende, Vitor Bortolo de Melo, Fernanda Ludolf Ribeiro de Garcia, Cristiana Couto Andrade, Jesuanne Carla Silva Rocha, Ismael Artur da Costa Bastos, Michele de Souza Rocha, Lucia Alves da Silva, Valderjane Aprigio Ferreira, Ewerton da Silva Marinho, Eveny Perlize Melo Costa, Allyson Guimarães Gomes, Matheus de Souza Amaral, Laurence Rodrigues Furtado, Erilene Cristina da Silva Silva, Eliana Vieira Pinto da Ramos, Bruna Alves Santos, Éder Barros dos Freitas, Maria Nazaré Oliveira Vasconcelos, Pedro Fernando da Costa Martins Filho, Olindo Assis Araújo, Márcio Sobreira Silva Ferreira, Milene Silveira Martins, Livia Carício |
| dc.subject.other.pt_BR.fl_str_mv |
Infecção por dengue Vírus da dengue Resposta imune Sorotipos DENV Quimiocinas Citocinas |
| topic |
Infecção por dengue Vírus da dengue Resposta imune Sorotipos DENV Quimiocinas Citocinas Dengue infection Dengue virus Immune response DENV serotypes Chemokines Cytokines |
| dc.subject.en.pt_BR.fl_str_mv |
Dengue infection Dengue virus Immune response DENV serotypes Chemokines Cytokines |
| description |
Instituto Evandro Chagas. Departamento de Arboviroses e Febres Hemorrágicas. Ananindeua, PA, Brasil. |
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2022 |
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2022-08-01T11:57:25Z |
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2022-08-01T11:57:25Z |
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2022 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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SILVA, Mikelly Santos Coutinho da et al. Serum Soluble Mediator Profiles and Networks During Acute Infection With Distinct DENV Serotypes. Frontiers in Immunology, v. 13, Article 892990, p. 1 - 12, May 2022. |
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https://www.arca.fiocruz.br/handle/icict/54092 |
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1664-3224 |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fimmu.2022.892990 |
| identifier_str_mv |
SILVA, Mikelly Santos Coutinho da et al. Serum Soluble Mediator Profiles and Networks During Acute Infection With Distinct DENV Serotypes. Frontiers in Immunology, v. 13, Article 892990, p. 1 - 12, May 2022. 1664-3224 10.3389/fimmu.2022.892990 |
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eng |
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eng |
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Frontiers Media |
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Frontiers Media |
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MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813008883758661632 |