Case report: hepatitis in a child infected with SARS-CoV-2 presenting toll-like receptor 7 Gln11Leu single nucleotide polymorphism

Detalhes bibliográficos
Autor(a) principal: Pessoa, Natália Lima
Data de Publicação: 2021
Outros Autores: Bentes, Aline Almeida, Carvalho, Andrea Lucchesi de, Silva, Thaís Bárbara de Souza, Alves, Pedro Augusto, Reis, Erik Vinicius de Sousa, Rodrigues, Tayse Andrade, Kroon, Erna Geessien, Campos, Marco Antônio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51435
Resumo: Universidade Federal de Minas Gerais. Departamento de Microbiologia. Laboratório de Vírus. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Imunologia de Doenças Virais. Belo Horizonte, MG, Brazil.
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spelling Pessoa, Natália LimaBentes, Aline AlmeidaCarvalho, Andrea Lucchesi deSilva, Thaís Bárbara de SouzaAlves, Pedro AugustoReis, Erik Vinicius de SousaRodrigues, Tayse AndradeKroon, Erna GeessienCampos, Marco Antônio2022-02-23T16:30:11Z2022-02-23T16:30:11Z2021PESSOA, Natália Lima et al. Case report: hepatitis in a child infected with SARS-CoV-2 presenting toll-like receptor 7 Gln11Leu single nucleotide polymorphism. Virology Journal, v. 18, n. 1, p. 1-5, 2021.1743-422Xhttps://www.arca.fiocruz.br/handle/icict/5143510.1186/s12985-021-01656-3engBioMed CentralCase report: hepatitis in a child infected with SARS-CoV-2 presenting toll-like receptor 7 Gln11Leu single nucleotide polymorphisminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Departamento de Microbiologia. Laboratório de Vírus. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Imunologia de Doenças Virais. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil / Fundação Hospitalar do Estado de Minas Gerais. Hospital João Paulo II. Belo Horizonte, MG, Brazil.Fundação Hospitalar do Estado de Minas Gerais. Hospital João Paulo II. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Imunologia de Doenças Virais. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Imunologia de Doenças Virais. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Imunologia de Doenças Virais. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Departamento de Microbiologia. Laboratório de Vírus. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil / Quibasa Química Básica. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Departamento de Microbiologia. Laboratório de Vírus. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Imunologia de Doenças Virais. Belo Horizonte, MG, Brazil.Background: Covid-19 has the respiratory tract as the main target of infection, and patients present mainly dyspnea, pneumonia, dry cough, and fever. Nevertheless, organs outside the respiratory tract had been reported in recent studies, including the gastrointestinal tract and liver. The host innate immune system recognizes pathogen-associated molecular patterns (PAMPs) through their pattern recognition receptor (PRRs). Toll-like receptor 7 (TLR-7) is a pattern recognition receptor recognizing ssRNA (SARS-CoV-2 is an ssRNA). Polymorphisms are characterized by two or more alternative forms of a distinct phenotype in the same population. Polymorphisms in tlrs genes can negatively influence the immune response to infectious diseases. There are several references in the literature to non-synonymous single nucleotide (rs) polymorphisms related to several genes. Some of them are important for the innate immunity, as rs 179008 (tlr-7), rs3775291 (tlr3), rs8177374 (tir domain-containing adaptor protein, tirap), rs1024611 (monocyte chemoattractant protein-1, mcp-1) and rs61942233 (2'-5'-oligoadenylate synthase-3, oas-3). Case presentation: We identified a 5-year-old-male child with gastrointestinal symptoms and fever presenting acholic stool and jaundice, who was positive for SARS-CoV-2 IgM, IgA, and IgG and presenting the Gln11Leu rs 179008 in tlr-7. The child presented high levels of aspartate aminotransferase, alanine aminotransferase, bilirubin, C-reactive protein, D-dimer, gamma-glutamyl transferase, alkaline phosphatase, and was negative for serological tests for hepatitis A, B, C, E, HIV 1 and 2, herpes virus, cytomegalovirus, Epstein-Barr virus, and negative for RTqPCR for Influenza A and B, RSV and SARS-CoV-2. We also investigated other SNPs in the tlr-3 (rs3775291), tirap (rs8177374), mcp-1 (rs1024611), and oas-3 (rs61942233) genes, and no mutation was detected. After an interview with the child's caregivers, any possible accidental ingestion of drugs or hepatotoxic substances was ruled out. Conclusion: To our knowledge, this is the first report of a SARS-CoV-2 caused hepatitis in a male child that has the tlr-7 Gln11Leu rs 179008, which could impair an efficient initial immune response. The knowledge of the patient's immune deficiency could improve the treatment to correct this deficiency with specific medications.ChildrenCOVID-19HepatitisInnate immune defenseSARS-CoV-2Single nucleotide polymorphismTLR-7Toll-like receptor 7 Gln11Leuinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/51435/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALCase report.pdfCase report.pdfapplication/pdf4053679https://www.arca.fiocruz.br/bitstream/icict/51435/2/Case%20report.pdf23e506261e5210e94680c4e274543a11MD52icict/514352022-07-18 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dc.title.pt_BR.fl_str_mv Case report: hepatitis in a child infected with SARS-CoV-2 presenting toll-like receptor 7 Gln11Leu single nucleotide polymorphism
title Case report: hepatitis in a child infected with SARS-CoV-2 presenting toll-like receptor 7 Gln11Leu single nucleotide polymorphism
spellingShingle Case report: hepatitis in a child infected with SARS-CoV-2 presenting toll-like receptor 7 Gln11Leu single nucleotide polymorphism
Pessoa, Natália Lima
Children
COVID-19
Hepatitis
Innate immune defense
SARS-CoV-2
Single nucleotide polymorphism
TLR-7
Toll-like receptor 7 Gln11Leu
title_short Case report: hepatitis in a child infected with SARS-CoV-2 presenting toll-like receptor 7 Gln11Leu single nucleotide polymorphism
title_full Case report: hepatitis in a child infected with SARS-CoV-2 presenting toll-like receptor 7 Gln11Leu single nucleotide polymorphism
title_fullStr Case report: hepatitis in a child infected with SARS-CoV-2 presenting toll-like receptor 7 Gln11Leu single nucleotide polymorphism
title_full_unstemmed Case report: hepatitis in a child infected with SARS-CoV-2 presenting toll-like receptor 7 Gln11Leu single nucleotide polymorphism
title_sort Case report: hepatitis in a child infected with SARS-CoV-2 presenting toll-like receptor 7 Gln11Leu single nucleotide polymorphism
author Pessoa, Natália Lima
author_facet Pessoa, Natália Lima
Bentes, Aline Almeida
Carvalho, Andrea Lucchesi de
Silva, Thaís Bárbara de Souza
Alves, Pedro Augusto
Reis, Erik Vinicius de Sousa
Rodrigues, Tayse Andrade
Kroon, Erna Geessien
Campos, Marco Antônio
author_role author
author2 Bentes, Aline Almeida
Carvalho, Andrea Lucchesi de
Silva, Thaís Bárbara de Souza
Alves, Pedro Augusto
Reis, Erik Vinicius de Sousa
Rodrigues, Tayse Andrade
Kroon, Erna Geessien
Campos, Marco Antônio
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pessoa, Natália Lima
Bentes, Aline Almeida
Carvalho, Andrea Lucchesi de
Silva, Thaís Bárbara de Souza
Alves, Pedro Augusto
Reis, Erik Vinicius de Sousa
Rodrigues, Tayse Andrade
Kroon, Erna Geessien
Campos, Marco Antônio
dc.subject.en.pt_BR.fl_str_mv Children
COVID-19
Hepatitis
Innate immune defense
SARS-CoV-2
Single nucleotide polymorphism
TLR-7
Toll-like receptor 7 Gln11Leu
topic Children
COVID-19
Hepatitis
Innate immune defense
SARS-CoV-2
Single nucleotide polymorphism
TLR-7
Toll-like receptor 7 Gln11Leu
description Universidade Federal de Minas Gerais. Departamento de Microbiologia. Laboratório de Vírus. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Imunologia de Doenças Virais. Belo Horizonte, MG, Brazil.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-02-23T16:30:11Z
dc.date.available.fl_str_mv 2022-02-23T16:30:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PESSOA, Natália Lima et al. Case report: hepatitis in a child infected with SARS-CoV-2 presenting toll-like receptor 7 Gln11Leu single nucleotide polymorphism. Virology Journal, v. 18, n. 1, p. 1-5, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51435
dc.identifier.issn.pt_BR.fl_str_mv 1743-422X
dc.identifier.doi.none.fl_str_mv 10.1186/s12985-021-01656-3
identifier_str_mv PESSOA, Natália Lima et al. Case report: hepatitis in a child infected with SARS-CoV-2 presenting toll-like receptor 7 Gln11Leu single nucleotide polymorphism. Virology Journal, v. 18, n. 1, p. 1-5, 2021.
1743-422X
10.1186/s12985-021-01656-3
url https://www.arca.fiocruz.br/handle/icict/51435
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51435/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51435/2/Case%20report.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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